Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction

Autor: Kateryna Sopova, Simon Tual-Chalot, Matthias Mueller-Hennessen, Nikolaos I. Vlachogiannis, Georgios Georgiopoulos, Moritz Biener, Marco Sachse, Andrey Turchinovich, Maria Polycarpou-Schwarz, Luke Spray, Eleni Maneta, Karim Bennaceur, Ashfaq Mohammad, Gavin David Richardson, Aikaterini Gatsiou, Harald F. Langer, Norbert Frey, Kimon Stamatelopoulos, Joerg Heineke, Daniel Duerschmied, Evangelos Giannitsis, Ioakim Spyridopoulos, Konstantinos Stellos

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Background and aimsPreclinical data suggest that activation of the adaptive immune system is critical for myocardial repair processes in acute myocardial infarction. The aim of the present study was to determine the clinical value of baseline effecto

Externí odkaz: https://doaj.org/article/fec2484f93934b1286423f6680cd23fa

Exogenous TGFβ1 and its mimic HpTGM attenuate the heart’s inflammatory response to ischaemic injury and improve long term cardiac outcomes

Autor: Rachael E. Redgrave, Esha Singh, Simon Tual-Chalot, Catherine Park, Darroch Hall, Karim Bennaceur, Danielle J. Smyth, Rick M. Maizels, Ioakim Spyridopoulos, Helen M. Arthur

RationaleSuccessful and timely coronary reperfusion following acute ST-elevation myocardial infarction (STEMI) is standard therapy to salvage transiently ischaemic heart muscle. However, the subsequent inflammatory response within the infarct can lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44bccdf3befd37fa3c86f1a8e6717976
https://doi.org/10.1101/2023.04.18.537417

Role of CMV-serostatus and CX3CR1 on lymphocyte kinetics and left ventricular remodelling in patients with acute myocardial infarction

Autor: Stephen Boag, Suzanne Cormack, Gavin D. Richardson, Luke Spray, A Mohammad, Ioakim Spyridopoulos, Catherine Park, Konstantinos Stellos, Pedram Panahi, Karim Bennaceur, Helen M. Arthur

Publikováno v: European Heart Journal. 41

Background Patients with latent cytomegalovirus (CMV) infection have higher rates of adverse cardiovascular outcomes, but the reasons for this remain elusive. CMV-induced changes to T-lymphocyte populations, with a proliferation of CMV-specific, CX3C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9882e4c26838538347b39530063a0f6
https://doi.org/10.1093/ehjci/ehaa946.1289

Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial (Preprint)

Autor: Rebecca Maier, Bilal Bawamia, Karim Bennaceur, Sarah Dunn, Leanne Marsay, Roland Amoah, Adetayo Kasim, Andrew Filby, David Austin, Helen Hancock, Ioakim Spyridopoulos

BACKGROUND Inflammation plays a key role in the pathophysiology of coronary heart disease (CHD) and its acute manifestation, acute coronary syndrome (ACS). Aging is associated with a decline of the immune system, a process known as immunosenescence.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ae92091342556eec425d20e916c7765
https://doi.org/10.2196/preprints.19456

Impact of the surface energy coefficient on the deformation properties of atomic nuclei as predicted by Skyrme energy density functionals

Autor: Michaël Bender, Karim Bennaceur, Paul-Henri Heenen, Wouter Ryssens, Jacques Meyer

Publikováno v: Phys.Rev.C
Phys.Rev.C, 2019, 99 (4), pp.044315. ⟨10.1103/PhysRevC.99.044315⟩
Physical Review C
Physical Review C, American Physical Society, 2019, 99 (4), pp.044315. ⟨10.1103/PhysRevC.99.044315⟩
Physical Review C, 99 (4

Background: In the framework of nuclear energy density functional (EDF) methods, many nuclear phenomena are related to the deformation of intrinsic states. Their accurate modeling relies on the correct description of the change of nuclear binding ene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72201dbf02bc0795b359a6d6d059c347
https://hal.archives-ouvertes.fr/hal-01885860