Výsledky vyhledávání - "Karien M. Hamer"

The use of a stringent selection system allows the identification of DNA elements that augment gene expression

Autor: Karien M. Hamer, Femke Hoeksema, John Antonius Verhees, Tjalling Siersma, Rik van Blokland, Michel Siep, Arie P. Otte, Jan L. den Blaauwen

Publikováno v: Molecular Biotechnology, 48(1), 19-29. Humana Press
Molecular Biotechnology

The use of high stringency selection systems often results in the induction of very few recombinant mammalian cell lines, which limits the ability to isolate a cell line with favorable characteristics. The employment of for instance STAR elements in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ea28a9a154d12db2f14d2eea7b4620
https://hdl.handle.net/11245/1.348059

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Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome

Autor: Kathrin Plath, Karien M. Hamer, Barbara Panning, Thomas P. Yang, Dale Talbot, Rudolf Jaenisch, Arie P. Otte

Publikováno v: The Journal of cell biology, vol 167, iss 6
Journal of Cell Biology, 167, 1025-1035. Rockefeller University Press
The Journal of Cell Biology

Polycomb group (PcG) proteins belonging to the polycomb (Pc) repressive complexes 1 and 2 (PRC1 and PRC2) maintain homeotic gene silencing. In Drosophila, PRC2 methylates histone H3 on lysine 27, and this epigenetic mark facilitates recruitment of PR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d48da477ff62f2ab266bb00b76fd35
https://doi.org/10.1083/jcb.200409026

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Selective Interactions between Vertebrate Polycomb Homologs and the SUV39H1 Histone Lysine Methyltransferase Suggest that Histone H3-K9 Methylation Contributes to Chromosomal Targeting of Polycomb Group Proteins

Autor: Arie P. Otte, Thijs Hendrix, Richard George Antonius Bernardus Sewalt, Dieter Schweizer, Martin Melcher, Monika Lachner, Karien M. Hamer, Mark Vargas, Jan L. den Blaauwen, Thomas Jenuwein

Publikováno v: Molecular and Cellular Biology. 22:5539-5553

Polycomb group (PcG) proteins form multimeric chromatin-associated protein complexes that are involved in heritable repression of gene activity. Two distinct human PcG complexes have been characterized. The EED/EZH2 PcG complex utilizes histone deace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bace20ef47010be248e82a4ea8269d40
https://doi.org/10.1128/mcb.22.15.5539-5553.2002

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Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma

Autor: Chris J.L.M. Meijer, Karien M. Hamer, Arie P. Otte, Folkert J. van Kemenade, Elly Fieret, Tjasso Blokzijl, David P. E. Satijn, Frank M. Raaphorst

Publikováno v: Blood. 97:3896-3901

Polycomb-group (PcG) proteins, such as BMI-1 and EZH2, form multimeric gene-repressing complexes involved in axial patterning, hematopoiesis, and cell cycle regulation. In addition, BMI-1 is involved in experimental lymphomagenesis. Little is known a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d55aef81839b277ea233aa388fe8d9
https://doi.org/10.1182/blood.v97.12.3896

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Distinct MBI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation

Autor: Karien M. Hamer, Folkert J. van Kemenade, Chris J.L.M. Meijer, Elly Fieret, Arie P. Otte, Frank M. Raaphorst, Tjasso Blokzijl, David P. E. Satijn

Publikováno v: The journal of immunology, 166, 5925-5934. American Association of Immunologists

BMI-1 and EZH2 Polycomb-group (PcG) proteins belong to two distinct protein complexes involved in the regulation of hematopoiesis. Using unique PcG-specific antisera and triple immunofluorescence, we found that mature resting peripheral T cells expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb411ab0d5d5e93984014fc0c503f57
https://doi.org/10.4049/jimmunol.166.10.5925

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Interference with the Expression of a Novel Human Polycomb Protein, hPc2, Results in Cellular Transformation and Apoptosis

Autor: Richard George Antonius Bernardus Sewalt, R. van Driel, Karien M. Hamer, C. Lambrechts, Arie P. Otte, David P. E. Satijn, J. van der Vlag, M. J. Gunster, D. J. Olson, H. Masselink

Publikováno v: Scopus-Elsevier
Molecular and Cellular Biology, 6076-6086. American Society for Microbiology
ISSUE=17;STARTPAGE=6076;ENDPAGE=6086;ISSN=0270-7306;TITLE=Molecular and Cellular Biology

Polycomb (Pc) is involved in the stable and heritable repression of homeotic gene activity during Drosophila development. Here, we report the identification of a novel human Pc homolog, hPc2. This gene is more closely related to a Xenopus Pc homolog,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d2b8280d78122705feb3ad65760611
https://doi.org/10.1128/mcb.17.10.6076

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RING1 Is Associated with the Polycomb Group Protein Complex and Acts as a Transcriptional Repressor

Autor: Karien M. Hamer, Wouter Schul, Paul S. Freemont, J. van der Vlag, R. van Driel, Mark J. Alkema, Andrew J. Saurin, M. J. Gunster, David P. E. Satijn, Arie P. Otte

Publikováno v: Europe PubMed Central

The Polycomb (Pc) protein is a component of a multimeric, chromatin-associated Polycomb group (PcG) protein complex, which is involved in stable repression of gene activity. The identities of components of the PcG protein complex are largely unknown.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6ac53ef72fc9e97bda943f32fa416e
https://doi.org/10.1128/mcb.17.7.4105

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Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other

Autor: Karien M. Hamer, Jan L. den Blaauwen, Ilse Schoneveld, Caro Lambrechts, Marlene J. Reijnen, Roel van Driel, Arie P. Otte

Publikováno v: Mechanisms of Developm., 53, 35-46. Elsevier

The Polycomb group genes in Drosophila are involved in the stable and inheritable repression of gene expression. The Polycomb group proteins probably operate as multimeric complexes that bind to chromatin. To investigate molecular mechanisms of stabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e54b39fda805bf662b6f8e76f9c028
https://hdl.handle.net/11245/1.116077

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Placing the RPL32 Promoter Upstream of a Second Promoter Results in a Strongly Increased Number of Stably Transfected Mammalian Cell Lines That Display High Protein Expression Levels

Autor: John Antonius Verhees, Femke Hoeksema, Arie P. Otte, Karien M. Hamer, Michel Siep

Publikováno v: Biotechnology Research International
Biotechnology Research International, 2011

The use of high stringency selection systems commonly results in a strongly diminished number of stably transfected mammalian cell lines. Here we placed twelve different promoters upstream of an adjacent primary promoter and tested whether this might

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7015fd2a1c550097edf25ea00ab969a5
https://pubmed.ncbi.nlm.nih.gov/21350661

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