DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states.

Autor: Liu Y; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Hrit JA; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Chomiak AA; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Stransky S; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Hoffman JR; Cell Signaling Technology, Danvers, MA 01923, USA., Tiedemann RL; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Wiseman AK; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Kariapper LS; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Dickson BM; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Worden EJ; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Fry CJ; Cell Signaling Technology, Danvers, MA 01923, USA., Sidoli S; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Rothbart SB; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: scott.rothbart@vai.org.

Publikováno v: Molecular cell [Mol Cell] 2024 Nov 25. Date of Electronic Publication: 2024 Nov 25.