Výsledky vyhledávání - "Kari-Wilder Romans"

Akademický článek

Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma

Publikováno v: Cancer & Metabolism, Vol 12, Iss 1, Pp 1-19 (2024)

Abstract Background Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine (H3K27M). DMG-H3K27M

Externí odkaz: https://doaj.org/article/1951e061c7ab4540990fd8c2ffa35723

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Akademický článek

Estrogen receptor inhibition mediates radiosensitization of ER-positive breast cancer models

Autor: Anna R. Michmerhuizen, Lynn M. Lerner, Andrea M. Pesch, Connor Ward, Rachel Schwartz, Kari Wilder-Romans, Meilan Liu, Charles Nino, Kassidy Jungles, Ruth Azaria, Alexa Jelley, Nicole Zambrana Garcia, Alexis Harold, Amanda Zhang, Bryan Wharram, Daniel F. Hayes, James M. Rae, Lori J. Pierce, Corey W. Speers

Publikováno v: npj Breast Cancer, Vol 8, Iss 1, Pp 1-12 (2022)

Abstract Endocrine therapy (ET) is an effective first-line therapy for women with estrogen receptor-positive (ER + ) breast cancers. While both ionizing radiation (RT) and ET are used for the treatment of women with ER+ breast cancer, the most effect

Externí odkaz: https://doaj.org/article/dcd32144b036459fac1d9db7b328ac9f

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Akademický článek

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcom

Externí odkaz: https://doaj.org/article/1b59daa1bcd04cf3a9e4d552dbc954ba

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Akademický článek

Neddylation inactivation represses androgen receptor transcription and inhibits growth, survival and invasion of prostate cancer cells

Autor: Xiaochen Zhou, Sumin Han, Kari Wilder-Romans, Grace Y. Sun, Hong Zhu, Xiaoqiang Liu, Mingjia Tan, Gongxian Wang, Felix Y. Feng, Yi Sun

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 4, Pp 192-202 (2020)

Androgen receptor (AR) and its constitutively active variants (AR-Vs) have been extensively implicated in the progression and recurrence of prostate cancer, making them attractive targets in the treatment of this disease. Whether and how neddylation

Externí odkaz: https://doaj.org/article/eb8fe4241b08410cbd747db27afe209e

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Akademický článek

Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment

Autor: Steven Kregel, Chao Wang, Xin Han, Lanbo Xiao, Ester Fernandez-Salas, Pushpinder Bawa, Brooke L. McCollum, Kari Wilder-Romans, Ingrid J. Apel, Xuhong Cao, Corey Speers, Shaomeng Wang, Arul M. Chinnaiyan

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 2, Pp 111-119 (2020)

Androgen receptor (AR) antagonists, such as enzalutamide, have had a major impact on the treatment of metastatic castration-resistant prostate cancer (CRPC). However, even with the advent of AR antagonist therapies, patients continue to develop resis

Externí odkaz: https://doaj.org/article/be9b782a16314be992d78a1c35b15b0f

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Akademický článek

Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

Publikováno v: Cancer & Metabolism, Vol 8, Iss 1, Pp 1-16 (2020)

Abstract Background Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support proliferation through

Externí odkaz: https://doaj.org/article/e08285467c004f0193e607f0286f4ab7

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Akademický článek

RB expression confers sensitivity to CDK4/6 inhibitor–mediated radiosensitization across breast cancer subtypes

Autor: Andrea M. Pesch, Nicole H. Hirsh, Anna R. Michmerhuizen, Kassidy M. Jungles, Kari Wilder-Romans, Benjamin C. Chandler, Meilan Liu, Lynn M. Lerner, Charles A. Nino, Connor Ward, Erin F. Cobain, Theodore S. Lawrence, Lori J. Pierce, James M. Rae, Corey W. Speers

Publikováno v: JCI Insight, Vol 7, Iss 3 (2022)

Standard radiation therapy (RT) does not reliably provide locoregional control for women with multinode-positive breast cancer and triple-negative breast cancer (TNBC). We hypothesized that CDK4/6 inhibition (CDK4/6i) would increase the radiosensitiv

Externí odkaz: https://doaj.org/article/a01908851a6948f19c0bebb697957f52

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Akademický článek

Seviteronel, a Novel CYP17 Lyase Inhibitor and Androgen Receptor Antagonist, Radiosensitizes AR-Positive Triple Negative Breast Cancer Cells

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

Increased rates of locoregional recurrence (LR) have been observed in triple negative breast cancer (TNBC) despite multimodality therapy, including radiation (RT). Recent data suggest inhibiting the androgen receptor (AR) may be an effective radiosen

Externí odkaz: https://doaj.org/article/a54f32bc80444bdc91e0c360229a5391

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