Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Kari T. Kivistö"'
Autor:
Heini Huhtala, Antti Haring, Ilkka Pörsti, Mika Kähönen, Arttu Eräranta, Kari T. Kivistö, Antti Tikkakoski, Lauri Suojanen, Jukka Mustonen
Publikováno v:
Artery Research, Vol 20 (2017)
Objective: Treatment with beta-blockers is characterised by inferior reduction of central versus peripheral blood pressure. We examined changes in central and peripheral blood pressure, cardiac function, and vascular resistance during beta-blockade.
Autor:
Jenni Koskela, Lauri Suojanen, Mika Kähönen, Arttu Eräranta, Anna Tahvanainen, Kari T. Kivistö, Jukka Mustonen, Antti Haring, Antti Tikkakoski, Kalle Sipilä, Ilkka Pörsti, Heini Huhtala
Publikováno v:
Basicclinical pharmacologytoxicology. 121(2)
Treatment with beta-blockers appears to show inferior reduction in central versus peripheral blood pressure. We aimed to examine simultaneous changes in central and peripheral blood pressure, vascular resistance, cardiac function and arterial stiffne
Autor:
F Wagner, Corinna Engel, D Bail, Svitlana Igel, Matthias Schwab, Michel Eichelbaum, Ute Hofmann, Klaus Mörike, R Fux, KD Hellberg, Gerhard Ziemer, Elke Schaeffeler, Siegfried Drescher, U. Delabar, Claudia Marx, JG Rein, Christoph H. Gleiter, Christoph Meisner, C Jägle, JO Böhm, Kari T. Kivistö
Publikováno v:
Clinical Pharmacology & Therapeutics. 84:104-110
We studied the efficacy of propafenone in preventing atrial tachyarrhythmias after cardiac surgery, and the possible relationships between CYP2D6 polymorphism and the efficacy, pharmacokinetics, and tolerability of propafenone. One hundred and sixty
Autor:
Leszek Wojnowski, Thomas Lang, Kari T. Kivistö, Pertti J. Neuvonen, Mikko Niemi, Janne T. Backman, Ulrich M. Zanger, Katja A. Arnold, Marja K. Pasanen, Ute Gödtel-Armbrust, Michel Eichelbaum
Publikováno v:
University of Helsinki
Our aim was to investigate possible effects of sequence variations in ABCC2, encoding the multidrug resistance-associated protein 2 (MRP2), on the pharmacokinetics of the MRP2 substrate pravastatin.Deoxyribonucleic acid samples of 41 healthy voluntee
Autor:
Kari T. Kivistö, Dagmar Busse, Michel Eichelbaum, Ute Hofmann, Matthias Schwab, Silke Templin, Gerd Mikus
Publikováno v:
European Journal of Clinical Pharmacology. 62:613-619
To characterise the comparative potency of optically pure (R)- and (S)-verapamil as regards negative dromotropic effects on atrioventricular (AV) node conduction and to compare the hemodynamic effects of single doses of the enantiomers in healthy vol
Autor:
Michel Eichelbaum, Klaus von Bergmann, Dieter Lütjohann, Mikko Niemi, Michael Igel, Kari T. Kivistö, Ute Hofmann, Katja A. Arnold, Matthias Schwab
Publikováno v:
Clinical Pharmacology & Therapeutics. 79:419-426
Background and Objective The polymorphism of SLCO1B1 (solute carrier organic anion transporter family, member 1B1), encoding the hepatic uptake transporter organic anion transporting polypeptide 1B1, has been associated with increased pravastatin con
Publikováno v:
Basic Toxicology. 98:51-54
The aim of this study was to examine the clinical profile of statin-induced myalgia in patients with no apparent predisposing factors. Patients who reported muscle complaints that limited daily functioning during statin use were prospectively identif
Impact of genotype on adverse effects during treatment with metoprolol: A prospective clinical study
Autor:
Ursula Delabar, Anne M.T. Pröhmer, Richard Fux, Gernot Lorenz, Elke Schaeffeler, Christoph H. Gleiter, Michel Eichelbaum, Kari T. Kivistö, Klaus Mörike, Matthias Schwab
Publikováno v:
Clinical Pharmacology & Therapeutics. 78:378-387
Objective Our objective was to study the impact of the cytochrome P450 (CYP) 2D6 polymorphism on the tolerability of metoprolol in a real-life primary care setting. The adverse effects studied comprised effects related to the central nervous system,
Autor:
Kari T. Kivistö, Klaus-Uwe Möritz, Konrad Meissner, Olaf Grisk, Ute Hofmann, Michel Eichelbaum, Katja A. Arnold, Heyo K. Kroemer, Dieter Lutjöohann, Klaus von Bergmann, Ingrid Klöting, Christoph A. Ritter
Publikováno v:
Drug Metabolism and Disposition. 33:1593-1596
The aim of this study was to characterize the role of the efflux transporter Mrp2 (Abcc2) in the pharmacokinetics of orally and intravenously administered pravastatin in rats. Eight Mrp2-deficient TR- rats and eight wild-type rats were given an oral
Autor:
Pertti J. Neuvonen, Kari T. Kivistö, Julian B. S. Leathart, Mikko Niemi, Mikko Neuvonen, Janne T. Backman, Lauri I. Kajosaari, Ann K. Daly, Michel Eichelbaum
Publikováno v:
Clinical Pharmacology & Therapeutics. 77:468-478
Background and Objective A large interindividual variability exists in the plasma concentrations of repaglinide. Our aim was to investigate possible associations between the pharmacokinetics of repaglinide and single nucleotide polymorphisms (SNPs) i