Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kari R. Fonseca"'
Autor:
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O’Neil, Patrick Trapa, Kari R. Fonseca, John Litchfield, Timothy McCarthy, Richard E. Carson, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a
Externí odkaz:
https://doaj.org/article/0b2d2f0ac72047df80a3f5d00a8935c1
Autor:
Tara L. Moore, Damon A. Young, Ronald J. Killiany, Kari R. Fonseca, Dmitri Volfson, David L. Gray, Rita Balice-Gordon, Rouba Kozak
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Aged-related declines in cognition, especially working memory and executive function, begin in middle-age and these abilities are known to be mediated by the prefrontal cortex (PFC) and more specifically the dopamine (DA) system within the PFC. In bo
Externí odkaz:
https://doaj.org/article/de9abf602a974353b8531c96d2cb9afe
Autor:
Michelle R. Garnsey, Aaron C. Smith, Jana Polivkova, Autumn L. Arons, Guoyun Bai, Caroline Blakemore, Markus Boehm, Leanne M. Buzon, Sarah N. Campion, Matthew Cerny, Shiao-Chi Chang, Karen Coffman, Kathleen A. Farley, Kari R. Fonseca, Kristen K. Ford, Jeonifer Garren, Jimmy X. Kong, Martin R. M. Koos, Daniel W. Kung, Yajing Lian, Monica M. Li, Qifang Li, Luis A. Martinez-Alsina, Rebecca O’Connor, Kevin Ogilvie, Kiyoyuki Omoto, Brian Raymer, Matthew R. Reese, Tim Ryder, Lacey Samp, Kimberly A. Stevens, Daniel W. Widlicka, Qingyi Yang, Kaicheng Zhu, Jean-Philippe Fortin, Matthew F. Sammons
Publikováno v:
Journal of Medicinal Chemistry. 66:3195-3211
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ba50d658838cab5c2164045c8015f51
https://doi.org/10.1021/acs.jmedchem.2c02012
https://doi.org/10.1021/acs.jmedchem.2c02012
Autor:
Yan Weng, Kari R. Fonseca, Yi-an Bi, Sumathy Mathialagan, Keith Riccardi, Elaine Tseng, Andrew J. Bessire, Mathew A. Cerny, David A. Tess, A. David Rodrigues, Amit S. Kalgutkar, John Litchfield, Li Di, Manthena V. S. Varma
Publikováno v:
Drug Metabolism and Disposition. 50:1312-1321
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebf00f47e216d78cc961dc9e84ae92d0
https://doi.org/10.1124/dmd.122.000953
https://doi.org/10.1124/dmd.122.000953
Autor:
David A, Tess, Emi, Kimoto, Amanda, King-Ahmad, Manoli, Vourvahis, A David, Rodrigues, Arthur, Bergman, Ruolun, Qui, Veena, Somayaji, Yan, Weng, Kari R, Fonseca, John, Litchfield, Manthena V S, Varma
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:605-614
PF-06835919 is a first-in-class ketohexokinase inhibitor (KHKi), recently under development for the treatment of metabolic and fatty liver diseases, which inhibited organic anion transporting polypeptide (OATP)1B1 in vitro and presented drug-drug int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35798cb3081f488864d3fc6e5ea68ef
https://doi.org/10.1002/cpt.2593
https://doi.org/10.1002/cpt.2593
Autor:
David Gray, Kari R. Fonseca, Damon Young, Michael Popiolek, Julie Brevard, Rouba Kozak, Patrick Trapa
Publikováno v:
ACS Chemical Neuroscience. 11:560-566
Parkinson's disease is a progressive neurodegenerative disease characterized by striatal dopaminergic loss. L-DOPA treatment replaces lost dopamine and enables motor function; however, eventually, fluctuating efficacy and side effects associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e6cc42966dee5f65d87155b15cfa9c
https://doi.org/10.1021/acschemneuro.9b00589
https://doi.org/10.1021/acschemneuro.9b00589
Autor:
Akihiro Takano, Nahid Amini, Edmund J. Keliher, Christer Halldin, Lei Zhang, Richard E. Carson, Patrick Trapa, Sangram Nag, Ryosuke Arakawa, Deane M. Nason, Kevin P. Maresca, Zhisheng Jia, John Litchfield, Tarek A. Samad, Christopher Ryan Butler, Justin R. Piro, Timothy J. McCarthy, Deborah L. Smith, Steve O’Neil, Kari R. Fonseca
Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b463c48140050426b0c96d37c2ff81
https://doi.org/10.21203/rs.3.rs-510615/v2
https://doi.org/10.21203/rs.3.rs-510615/v2
Autor:
Ryosuke, Arakawa, Akihiro, Takano, Sangram, Nag, Zhisheng, Jia, Nahid, Amini, Kevin P, Maresca, Lei, Zhang, Edmund J, Keliher, Christopher R, Butler, Justin R, Piro, Tarek A, Samad, Deborah, Smith, Deane, Nason, Steve, O'Neil, Patrick, Trapa, Kari R, Fonseca, John, Litchfield, Timothy, McCarthy, Richard E, Carson, Christer, Halldin
Publikováno v:
EJNMMI research. 12(1)
Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [Seven cynomolgus monkeys were enrolled for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a98c606e14bcd5e9f645c4b6b371c6bf
https://pubmed.ncbi.nlm.nih.gov/35244788
https://pubmed.ncbi.nlm.nih.gov/35244788
Autor:
Bruce N. Rogers, Simone Sciabola, Kari R. Fonseca, Natasha M. Kablaoui, David Gray, Michelle Vanase-Frawley, Guoyun Bai, Gilles H. Goetz, Allen J. Duplantier
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:3513-3520
Oxytocin (OT) is a peptide hormone agonist of the OT receptor (OTR) that plays an important role in social behaviors such as pair bonding, maternal bonding and trust. The pharmaceutical development of OT as an oral peptide therapeutic has been hinder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f865f06d5830b8a9ab10ad8278bb10
https://doi.org/10.1016/j.bmc.2016.05.062
https://doi.org/10.1016/j.bmc.2016.05.062
Autor:
Timothy L. Foley, Justin I. Montgomery, Daniel P. Uccello, Anthony R. Harris, Steven Victor O'neil, Bruce N. Rogers, Douglas S. Johnson, Justin R. Piro, Tarek A. Samad, Christopher Ryan Butler, Stephen Noell, Rafael G. Silva, Deane M. Nason, Christopher John Helal, Adam M. Gilbert, Julie Cianfrogna, Laura A. McAllister, Scot Richard Mente, Christopher L. Shaffer, Kari R. Fonseca, Damien Webb, Jayvardhan Pandit, Michael Aaron Brodney
Publikováno v:
Journal of medicinal chemistry. 61(7)
Monoacylglycerol lipase (MAGL) inhibition provides a potential treatment approach to neuroinflammation through modulation of both the endocannabinoid pathway and arachidonoyl signaling in the central nervous system (CNS). Herein we report the discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ba4448563e7b467bb25a055a46ddd6
https://pubmed.ncbi.nlm.nih.gov/29498843
https://pubmed.ncbi.nlm.nih.gov/29498843