Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Kari Nejak-Bowen"'
Autor:
Mary Ayers, Karis Kosar, Yuhua Xue, Chhavi Goel, Matthew Carson, Elizabeth Lee, Silvia Liu, Eva Brooks, Pamela Cornuet, Michael Oertel, Bharat Bhushan, Kari Nejak-Bowen
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 6, Pp 895-921 (2023)
Background & Aims: β-Catenin, the effector molecule of the Wnt signaling pathway, has been shown to play a crucial role in bile acid homeostasis through direct inhibition of farnesoid X receptor (FXR), which has pleiotropic effects on bile acid home
Externí odkaz:
https://doaj.org/article/d2779cf093ec4bc390894535e93c2550
Autor:
Satdarshan P. Monga, Kari Nejak-Bowen
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 3, Pp 806-808 (2023)
Externí odkaz:
https://doaj.org/article/5086b36c74ce444d9707c063e553e474
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0282358 (2023)
[This corrects the article DOI: 10.1371/journal.pone.0059836.].
Externí odkaz:
https://doaj.org/article/608cf6a1981d45fea296857e5471a9e0
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Primary sclerosing cholangitis (PSC) is a rare, chronic, cholestatic liver disease characterized by progressive inflammation and fibrosis of the bile ducts. We have previously demonstrated the importance of Wnt/β-catenin signaling in mouse
Externí odkaz:
https://doaj.org/article/ad44fe786d194eccb1d030e8ee13482c
Autor:
Karis Kosar, Pamela Cornuet, Sucha Singh, Elizabeth Lee, Silvia Liu, Jenesis Gayden, Toshifumi Sato, Zachary Freyberg, Gavin Arteel, Kari Nejak‐Bowen
Publikováno v:
Hepatology Communications, Vol 5, Iss 12, Pp 2019-2034 (2021)
We previously identified an up‐regulation of specific Wnt proteins in the cholangiocyte compartment during cholestatic liver injury and found that mice lacking Wnt secretion from hepatocytes and cholangiocytes showed fewer proliferating cholangiocy
Externí odkaz:
https://doaj.org/article/c151200c32814023a236e26d6f6575c4
Autor:
Rong Zhang, Toshimasa Nakao, Jing Luo, Yuhua Xue, Pamela Cornuet, Michael Oertel, Karis Kosar, Sucha Singh, Kari Nejak‐Bowen
Publikováno v:
Hepatology Communications, Vol 3, Iss 12, Pp 1642-1655 (2019)
We have recently shown that loss of β‐catenin prevents the development of cholestatic liver injury and fibrosis after bile duct ligation (BDL) due to loss of the inhibitory farnesoid X receptor (FXR)/β‐catenin complex, which results in decrease
Externí odkaz:
https://doaj.org/article/339a9d1d22cc4a5b9eedff33b703da43
Autor:
Shikai Hu, Jacquelyn O Russell, Silvia Liu, Catherine Cao, Jackson McGaughey, Ravi Rai, Karis Kosar, Junyan Tao, Edward Hurley, Minakshi Poddar, Sucha Singh, Aaron Bell, Donghun Shin, Reben Raeman, Aatur D Singhi, Kari Nejak-Bowen, Sungjin Ko, Satdarshan P Monga
Publikováno v:
eLife, Vol 10 (2021)
Expansion of biliary epithelial cells (BECs) during ductular reaction (DR) is observed in liver diseases including cystic fibrosis (CF), and associated with inflammation and fibrosis, albeit without complete understanding of underlying mechanism. Usi
Externí odkaz:
https://doaj.org/article/01ba755c7dab41ab8470c5fde355f0f3
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59836 (2013)
Hepatocyte growth factor (HGF) has been shown to be indispensable for liver regeneration because it serves as a main mitogenic stimulus driving hepatocytes toward proliferation. We hypothesized that ablating HGF in adult mice would have a negative ef
Externí odkaz:
https://doaj.org/article/b3d328dbe031419bbe5eea9436283ca1
Autor:
Shikai Hu, Laura Molina, Junyan Tao, Silvia Liu, Mohammed Hassan, Sucha Singh, Minakshi Poddar, Aaron Bell, Daniela Sia, Michael Oertel, Reben Raeman, Kari Nejak-Bowen, Aatur Singhi, Jianhua Luo, Satdarshan P. Monga, Sungjin Ko
Publikováno v:
Gastroenterology. 163:449-465
Intrahepatic cholangiocarcinoma (ICC) is a devastating liver cancer with extremely high intra- and inter-tumoral molecular heterogeneity, partly due to its diverse cellular origins. We investigated clinical relevance and the molecular mechanisms unde
Autor:
Kari Nejak-Bowen, Satdarshan P. Monga
Publikováno v:
Hepatology.