Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

Autor: T J Moscarillo, Marie Ryder, Basavaraj Hooli, Lars Bertram, Kari Lynn Ohlsen, Iuliana Ionita, Brit Maren Michaud Schjeide, Diane Hu-Lince, Amy Murphy, K. David Becker, Kristina Mullin, Michele Parkinson, Steven L. Wagner, Rudolph E. Tanzi, Deborah Blacker, Kathryn J. Elliott, Xin Wang, Nan M. Laird, Monica Hsiao, Christoph Lange, Hongyu Jiang, Meghan F. Hogan, Jason DiVito

Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. To date four genes have been established to either cause early-onset autosomal-dominant AD (APP, PSEN1, and PSEN2(1-4)) or to increase susceptibility for late-onset AD (APO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3cde32cfba8ecadb8b41dd2d031130
https://europepmc.org/articles/PMC2668052/

STIM1, an essential and conserved component of store-operated Ca2+ channel function

Autor: Paul J. Digregorio, Shenyuan L. Zhang, Steven L. Wagner, Kari Lynn Ohlsen, Olga Safrina, Gonul Velicelebi, Michael D. Cahalan, Andriy V. Yeromin, Maria I. Lioudyno, Kenneth A. Stauderman, Jack Roos, J. Ashot Kozak

Publikováno v: The Journal of Cell Biology
Roos, J; DiGregorio, PJ; Yeromin, AV; Ohlsen, K; Lioudyno, M; Zhang, S; et al.(2005). STIM1, an essential and conserved component of store-operated Ca 2+ channel function. Journal of Cell Biology, 169(3), 435-445. doi: 10.1083/jcb.200502019. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/14k0n6xh

Store-operated Ca2+ (SOC) channels regulate many cellular processes, but the underlying molecular components are not well defined. Using an RNA interference (RNAi)-based screen to identify genes that alter thapsigargin (TG)-dependent Ca2+ entry, we d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab56f9b8ee662346698c8a176590cc5
https://pubmed.ncbi.nlm.nih.gov/15866892