Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kari L. Murad"'
Publikováno v:
Science China Life Sciences. 54:589-598
Developing a practical means of reducing alloimmunization in chronically transfused patients would be of significant clinical benefit. Immunocamouflaging red blood cells (RBCs) by membrane grafting of methoxypoly(ethylene glycol) (mPEG) may reduce th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9615d3428fd04778eeca2a28dbb090
https://doi.org/10.1007/s11427-011-4190-x
https://doi.org/10.1007/s11427-011-4190-x
Publikováno v:
SCIENTIA SINICA Vitae. 41:429-438
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e597fbc3c5829b0a4aefde46b19a57
https://doi.org/10.1360/zc2011-41-6-429
https://doi.org/10.1360/zc2011-41-6-429
Publikováno v:
Transfusion. 41:1225-1233
BACKGROUND: RBCs modified with cyanuric chloride activated methoxy-PEG (CmPEG; 5000 Da) are less immunogenic than untreated RBCs, and their use thus may reduce the risk of alloimmunization in chronically transfused patients. STUDY DESIGN AND METHODS:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395e40503a1115eb6dc0065a56d455ee
https://doi.org/10.1046/j.1537-2995.2001.41101225.x
https://doi.org/10.1046/j.1537-2995.2001.41101225.x
Publikováno v:
Transfusion Medicine Reviews. 14:53-63
The small number of studies done on the covalent modification of RBC with PEG, or PEG-derivatives, suggests that the immunocamouflage of intact cells significantly reduces the antigenicity and immunogenicity of the foreign cell. Importantly, this pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec60ae7ba362b71ec4f88e53c7a9140c
https://doi.org/10.1016/s0887-7963(00)80115-7
https://doi.org/10.1016/s0887-7963(00)80115-7
Publikováno v:
Blood. 94:2135-2141
Transfusion or transplantation of T lymphocytes into an allogeneic recipient can evoke potent immune responses including, in immunocompromised patients, graft-versus-host disease (GVHD). As our previous studies demonstrated attenuated immunorecogniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91325f35fdfa53212294717da8dba23a
https://doi.org/10.1182/blood.v94.6.2135
https://doi.org/10.1182/blood.v94.6.2135
Publikováno v:
Blood. 94:2135-2141
Transfusion or transplantation of T lymphocytes into an allogeneic recipient can evoke potent immune responses including, in immunocompromised patients, graft-versus-host disease (GVHD). As our previous studies demonstrated attenuated immunorecogniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34319591f3ab2990f702459ad7f26c66
https://doi.org/10.1182/blood.v94.6.2135.418k08_2135_2141
https://doi.org/10.1182/blood.v94.6.2135.418k08_2135_2141
Autor:
Mark D. Scott, Kari L. Murad, Kathleen L. Mahany, John W. Eaton, Frans A. Kuypers, Carlo Brugnara
Publikováno v:
Blood. 93:2121-2127
We previously showed that the covalent modification of the red blood cell (RBC) surface with methoxypoly(ethylene glycol) [mPEG; MW approximately 5 kD] could significantly attenuate the immunologic recognition of surface antigens. However, to make th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e48606cde8f758f767d24a08a0d032bb
https://doi.org/10.1182/blood.v93.6.2121.406a30_2121_2127
https://doi.org/10.1182/blood.v93.6.2121.406a30_2121_2127
Publikováno v:
Proceedings of the National Academy of Sciences. 94:7566-7571
In a number of clinical circumstances it would be desirable to artificially conceal cellular antigenic determinants to permit survival of heterologous donor cells. A case in point is the problem encountered in transfusions of patients with rare blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c178245ed9ff824920fb138b2dd88f1e
https://doi.org/10.1073/pnas.94.14.7566
https://doi.org/10.1073/pnas.94.14.7566
Autor:
Kari L. Murad, Mark D. Scott
Publikováno v:
ChemInform. 30
Immunological recognition of foreign cells is a primary concern in both transfusion and transplantation medicine. Our unique approach to this problem is to globally camouflage the surface of the foreign cell using nonimmunogenic, long chain polymers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d17cc39a635592358d951e70881ce6d
https://doi.org/10.1002/chin.199905269
https://doi.org/10.1002/chin.199905269
Publikováno v:
Biochimica et biophysica acta. 1561(2)
Immunocamouflaged red blood cells (RBC) are produced by cell surface derivatization with methoxypolyethylene glycol (mPEG). These immunologically attenuated cells may reduce the risk of allosensitization in chronically transfused patients. To charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529f3957b42799b7b59201e47be0e488
https://pubmed.ncbi.nlm.nih.gov/11997115
https://pubmed.ncbi.nlm.nih.gov/11997115