Experimental and Theoretical Investigation of the Coordination of 8-Hydroxquinoline Inhibitors to Biomimetic Zinc Complexes and Histone Deacetylase 8 (HDAC8)

Autor: Anthony M. Baudino, Harris F. Ciaccio, Michael J. Turski, Xavier A. Akins, Phoebus Sun Cao, Elisa Morales, Roger D. Sommer, Adam R. Johnson, Donald J. Wink, Kyle A. Grice, Kari L. Stone

Publikováno v: Foundations, Vol 4, Iss 3, Pp 362-375 (2024)

Zinc is integral to diverse biological functions, acting catalytically, structurally, and supportively in essential enzyme cycles, despite its limited amounts in the body. Targeting zinc enzymes with potent drugs, such as Vorinostat, demonstrates the

Externí odkaz: https://doaj.org/article/858b2f61f78e4bf4b6c49765069f8bc9

The professional identity of STEM faculty as instructors of course-based research experiences

Autor: David Hanauer, Richard Alvey, Ping An, Christa Bancroft, Kristen Butela, Sean Coleman, Kari L. Clase, Parks Collins, Stephanie Conant, Pamela Connerly, Bernadette Connors, Megan K. Dennis, Erin L. Doyle, Dustin Edwards, Christy Fillman, Ann Findley, Victoria J. Frost, Maria Gainey, Urszula Golebiewska, Nancy Guild, Sharon B. Gusky, Allison Johnson, Kristen Johnson, Karen K. Klyczek, Julia Lee-Soety, Heather Lindberg, Matthew D. Mastropaolo, Julie A. Merkle, Jon Mitchell, Sally Molloy, Fernando Nieto, Jillian Nissen, Tiara Perez Morales, Nick T. Peters, Susanne P. Pfeifer, Richard Pollenz, Mary L. Preuss, Germán Rosas-Acosta, Margaret S. Saha, Amy Sprenkle, C. Nicole Sunnen, Deborah Tobiason, Sara S. Tolsma, Vassie Ware, Yesmi Patricia Ahumada-Santos, Regina V. Alvarez, Justin Anderson, Mary Ayuk, María Elena Báez-Flores, Dondra Bailey, Frederick Baliraine, Elizabeth Behr, Andrea R. Beyer, Suparna Bhalla, Lisa M. Bono, Donald P. Breakwell, Christine Byrum, Iain Duffy, Alyssa Gleichsner, Melinda Harrison, Renee Ho, Lee E. Hughes, Jacob D. Kagey, Kathryn Kohl, Sean McClory, Alison Moyer, Maria A. Mussi, Holly Nance, Imade Y. Nsa, Shallee T. Page, Jesús Ricardo Parra Unda, Jessica Rocheleau, Sarah Swerdlow, Kara Thoemke, Megan S. Valentine, Quinn C. Vega, Catherine Ward, Daniel C. Williams, Ellen Wisner, William H. Biederman, Steven G. Cresawn, Mark J. Graham, Graham Hatfull, Danielle Heller, Deborah Jacobs-Sera, Denise Monti, Pushpa Ramakrishna, Daniel Russell, Viknesh Sivanathan

Publikováno v: Frontiers in Education, Vol 9 (2024)

The professional identity of scientists has historically been cultivated to value research over teaching, which can undermine initiatives that aim to reform science education. Course-Based Research Experiences (CRE) and the inclusive Research and Edu

Externí odkaz: https://doaj.org/article/21dd741f0857420e8bbeab64c35a9637

Trait-level predictors of human performance outcomes in personnel engaged in stressful laboratory and field tasks

Autor: Tad T. Brunyé, Sara Anne Goring, Julie A. Cantelon, Marianna D. Eddy, Seth Elkin-Frankston, Wade R. Elmore, Grace E. Giles, Clifford L. Hancock, Shoaib Bin Masud, James McIntyre, Kari L. McKenzie, K. Blake Mitchell, Meghan P. O’Donovan, Kenneth Racicot, John W. Ramsay

Publikováno v: Frontiers in Psychology, Vol 15 (2024)

IntroductionPersonnel performance under stress hinges on various factors, including individual traits, training, context, mental and physiological states, and task demands. This study explored the link between the traits of military personnel and the

Externí odkaz: https://doaj.org/article/e840eb603f454c8d8d5c66984c26bf41

Circuit dynamics of superficial and deep CA1 pyramidal cells and inhibitory cells in freely moving macaques

Autor: Saman Abbaspoor, Kari L. Hoffman

Publikováno v: Cell Reports, Vol 43, Iss 8, Pp 114519- (2024)

Summary: Diverse neuron classes in hippocampal CA1 have been identified through the heterogeneity of their cellular/molecular composition. How these classes relate to hippocampal function and the network dynamics that support cognition in primates re

Externí odkaz: https://doaj.org/article/0574e3c632184b128cd1be60fa75b551

Developmental pyrethroid exposure disrupts molecular pathways for circadian rhythms and MAP kinase in mouse brain.

Autor: Jennifer Nguyen, Melissa A. Curtis, Ali S. Imami, William G. Ryan, Khaled Alganem, Kari L. Neifer, Nilanjana Saferin, Charlotte N. Nawor, Brian P. Kistler, Gary W. Miller, Rammohan Shukla, Robert E. McCullumsmith

Publikováno v: Translation, Vol 12, Iss 3 (2024)

Externí odkaz: https://doaj.org/article/19421693822744e0944eb21064314f3a