Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Kari Kopra"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Thermal shift assay (TSA) with altered temperature has been the most widely used method for monitoring protein stability for drug research. However, there is a pressing need for isothermal techniques as alternatives. This urgent demand arise
Externí odkaz:
https://doaj.org/article/7599890d644e4e2badd1628ca8a580e5
Autor:
Negin Gooran, Kari Kopra
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1764 (2024)
Proteins are large biomolecules with a specific structure that is composed of one or more long amino acid chains. Correct protein structures are directly linked to their correct function, and many environmental factors can have either positive or neg
Externí odkaz:
https://doaj.org/article/4fa317881e0f4740a35d47c5bb43dc49
Autor:
Ania Wilczynska, Sarah L. Gillen, Tobias Schmidt, Hedda A. Meijer, Rebekah Jukes-Jones, Claudia Langlais, Kari Kopra, Wei-Ting Lu, Jack D. Godfrey, Benjamin R. Hawley, Kelly Hodge, Sara Zanivan, Kelvin Cain, John Le Quesne, Martin Bushell
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-21 (2019)
Abstract Background Regulation of the mRNA life cycle is central to gene expression control and determination of cell fate. miRNAs represent a critical mRNA regulatory mechanism, but despite decades of research, their mode of action is still not full
Externí odkaz:
https://doaj.org/article/7d0c484dc2a4472ab9ac49baaa014cd9
Publikováno v:
ACS Omega, Vol 4, Iss 15, Pp 16501-16507 (2019)
Externí odkaz:
https://doaj.org/article/29170cabf2e942eebfff265169475677
Publikováno v:
ACS Omega, Vol 4, Iss 2, Pp 4269-4275 (2019)
Externí odkaz:
https://doaj.org/article/d068f18412194e6399e98b0df6ee323e
Autor:
Kari Kopra, Salla Valtonen, Randa Mahran, Jonas N. Kapp, Nazia Hassan, William Gillette, Bryce Dennis, Lianbo Li, Kenneth D. Westover, Andreas Plückthun, Harri Härmä
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7095 (2022)
Thermal unfolding methods are commonly used as a predictive technique by tracking the protein’s physical properties. Inherent protein thermal stability and unfolding profiles of biotherapeutics can help to screen or study potential drugs and to fin
Externí odkaz:
https://doaj.org/article/55616800df26442e83ba885b4eee505a
Autor:
Salla Valtonen, Emmiliisa Vuorinen, Ville Eskonen, Morteza Malakoutikhah, Kari Kopra, Harri Härmä
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Protein aggregation is a spontaneous process affected by multiple external and internal properties, such as buffer composition and storage temperature. Aggregation of protein-based drugs can endanger patient safety due, for example, to increased immu
Externí odkaz:
https://doaj.org/article/3faa2234daa44908bdbbbd5ac19c4d0b
Autor:
Emmiliisa Vuorinen, Salla Valtonen, Nazia Hassan, Randa Mahran, Huda Habib, Morteza Malakoutikhah, Kari Kopra, Harri Härmä
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6362 (2021)
Proteases are a group of enzymes with a catalytic function to hydrolyze peptide bonds of proteins. Proteases regulate the activity, signaling mechanism, fate, and localization of many proteins, and their dysregulation is associated with various patho
Externí odkaz:
https://doaj.org/article/a4df3643f2114799b56022f107f47cfe
Autor:
Kari Kopra, Tanja Seppälä, Dana Rabara, Maria Abreu-Blanco, Sakari Kulmala, Matthew Holderfield, Harri Härmä
Publikováno v:
Sensors, Vol 18, Iss 11, p 3989 (2018)
A new label-free molecular probe for luminescent nucleotide detection in neutral aqueous solution is presented. Phosphate-containing molecules, such as nucleotides possess vital role in cell metabolism, energy economy, and various signaling processes
Externí odkaz:
https://doaj.org/article/6b3ededc4a444883a4ba72cd2756b06c
Autor:
Maja Šolman, Alessio Ligabue, Olga Blaževitš, Alok Jaiswal, Yong Zhou, Hong Liang, Benoit Lectez, Kari Kopra, Camilo Guzmán, Harri Härmä, John F Hancock, Tero Aittokallio, Daniel Abankwa
Publikováno v:
eLife, Vol 4 (2015)
Hotspot mutations of Ras drive cell transformation and tumorigenesis. Less frequent mutations in Ras are poorly characterized for their oncogenic potential. Yet insight into their mechanism of action may point to novel opportunities to target Ras. He
Externí odkaz:
https://doaj.org/article/a84df42c6ba14fc0a17e36dc361c148f