Výsledky vyhledávání

Recognition of Specific DNA Sequences by Stacked Pyrrole- and Imidazole- Containing Polyamides: An Efficient Screening Method Based on Competitive Dialysis

Autor: Cameron M. Howard, James A. Henry, N. M. Le, Moses Lee, Peter B. Uthe, Suzanna L. Bailey, Karen L. Buchmueller, Andrew M. Staples, Sarah M. Horick, Kari K. Cox

Publikováno v: Letters in Drug Design & Discovery. 2:137-142

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9079e3506890dc786c6e669b6fb92242
https://doi.org/10.2174/1570180053175160

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Extending the Language of DNA Molecular Recognition by Polyamides: Unexpected Influence of Imidazole and Pyrrole Arrangement on Binding Affinity and Specificity

Autor: N. Minh Le, Peter B. Uthe, Andrew M. Staples, Binh Nguyen, Cameron M. Howard, Karen L. Buchmueller, W. David Wilson, Kari K. Cox, Sarah M. Horick, Moses Lee, Kimberly A. O. Pacheco

Publikováno v: Journal of the American Chemical Society. 127:742-750

Pyrrole (Py) and imidazole (Im) polyamides can be designed to target specific DNA sequences. The effect that the pyrrole and imidazole arrangement, plus DNA sequence, have on sequence specificity and binding affinity has been investigated using DNA m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebba1103ee803acbf10d465e3d758205
https://doi.org/10.1021/ja044359p

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Recognition of Tmiddle dotG mismatched base pairs in DNA by stacked imidazole-containing polyamides: surface plasmon resonance and circular dichroism studies

Autor: Kari K. Cox, Eilyn R. Lacy, W. David Wilson, Moses Lee

Publikováno v: Nucleic Acids Research. 30:1834-1841

An imidazole-containing polyamide trimer, f-ImImIm, where f is a formamido group, was recently found using NMR methods to recognize T*G mismatched base pairs. In order to characterize in detail the T*G recognition affinity and specificity of imidazol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a062eabc8b60333869f1d5057b79fde
https://doi.org/10.1093/nar/30.8.1834

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Molecular recognition of DNA base pairs by the formamido/pyrrole and formamido/imidazole pairings in stacked polyamides

Autor: Moses Lee, Karen L. Buchmueller, Peter B. Uthe, Andrew M. Staples, Kari K. Cox, Cameron M. Howard, Suzanna L. Bailey, Binh Nguyen, W. David Wilson, Kimberly A. O. Pacheco, James A. Henry, Sarah M. Horick

Publikováno v: Nucleic Acids Research

Polyamides containing an N-terminal formamido (f) group bind to the minor groove of DNA as staggered, antiparallel dimers in a sequence-specific manner. The formamido group increases the affinity and binding site size, and it promotes the molecules t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a8f8c28886c5185f76b33b03edf9cd
https://pubmed.ncbi.nlm.nih.gov/15703305

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Energetic basis for selective recognition of T*G mismatched base pairs in DNA by imidazole-rich polyamides

Autor: Binh Nguyen, Caroline O'Hare, Minh Le, W. David Wilson, Eilyn R. Lacy, John A. Hartley, Kari K. Cox, Moses Lee

Publikováno v: Nucleic acids research. 32(6)

To complement available structure and binding results and to develop a detailed understanding of the basis for selective molecular recognition of T.G mismatches in DNA by imidazole containing polyamides, a full thermodynamic profile for formation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c4d5e7fa8ea555ed1d58cf904b685d
https://pubmed.ncbi.nlm.nih.gov/15064359

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Probing the Active Site of Yeast Alcohol Dehydrogenase through Microscale Yeast-Mediated Reductions of Acetophenone and Acetylpyridines. A Collaborative and Research-Based Advanced Bioorganic Chemistry Laboratory Project

Autor: Ray Feaster, Kari K. Cox, Moses Lee, Andrew Lam, James L. Toth, Brent Steadman, Michael A. Carnahan, Joey E. Espinosa, Shane G. Roller, Jennifer Azbell, Robert Hirsch

Publikováno v: Journal of Chemical Education. 77:363

A collaborative and research-oriented advanced bioorganic chemistry project that probed the structure and reactivity relationship of yeast alcohol dehydrogenase (YADH) is reported. The project involved microscale and stereoselective reductions of ace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb31b36aaad2242235eea0717b475221
https://doi.org/10.1021/ed077p363

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Akademický článek

A novel class of in vivo active anticancer agents: achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065.

Autor: Sato A; Department of Chemistry, Furman University, 3300 Poinsett Highway, Greenville, South Carolina 29613, USA., McNulty L, Cox K, Kim S, Scott A, Daniell K, Summerville K, Price C, Hudson S, Kiakos K, Hartley JA, Asao T, Lee M

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2005 Jun 02; Vol. 48 (11), pp. 3903-18.

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Akademický článek

A kinetic approach towards understanding substrate interactions and the catalytic mechanism of the serine/threonine protein kinase ERK2: identifying a potential regulatory role for divalent magnesium.

Autor: Waas WF; Division of Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA., Rainey MA, Szafranska AE, Cox K, Dalby KN

Publikováno v: Biochimica et biophysica acta [Biochim Biophys Acta] 2004 Mar 11; Vol. 1697 (1-2), pp. 81-7.

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