Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Kari J. Airenne"'
Autor:
Reetta A. E. Eriksson, Tiina Nieminen, Lionel Galibert, Sanna K. Peltola, Petra Tikkanen, Piia Käyhty, Hanna M. Leinonen, Igor Oruetxebarria, Saana Lepola, Anniina J. Valkama, Eevi M. Lipponen, Hanna P. Lesch, Seppo Ylä-Herttuala, Kari J. Airenne
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/577226a018c4442398fc2f758afd0a1c
Autor:
Reetta A. E. Eriksson, Tiina Nieminen, Lionel Galibert, Sanna K. Peltola, Petra Tikkanen, Piia Käyhty, Hanna M. Leinonen, Igor Oruetxebarria, Saana Lepola, Anniina J. Valkama, Eevi M. Lipponen, Hanna P. Lesch, Seppo Ylä-Herttuala, Kari J. Airenne
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Gene therapy would greatly benefit from a method to regulate therapeutic gene expression temporally. Riboswitches are small RNA elements that have been studied for their potential use in turning transgene expression on or off by ligand binding. We co
Externí odkaz:
https://doaj.org/article/bac6cbe4bcff4b7981f043f3a2f22c28
Autor:
Lionel Galibert, Amira Hyvönen, Reetta A. E. Eriksson, Salla Mattola, Vesa Aho, Sami Salminen, Justin D. Albers, Sanna K. Peltola, Saija Weman, Tiina Nieminen, Seppo Ylä-Herttuala, Hanna P. Lesch, Maija Vihinen-Ranta, Kari J. Airenne
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract With a limited coding capacity of 4.7 kb, adeno-associated virus (AAV) genome has evolved over-lapping genes to maximise the usage of its genome. An example is the recently found ORF in the cap gene, encoding membrane-associated accessory pr
Externí odkaz:
https://doaj.org/article/cfb778447b9c4cc69e2061b9fd481166
Autor:
Salla Mattola, Kari Salokas, Vesa Aho, Elina Mäntylä, Sami Salminen, Satu Hakanen, Einari A Niskanen, Julija Svirskaite, Teemu O Ihalainen, Kari J Airenne, Minna Kaikkonen-Määttä, Colin R Parrish, Markku Varjosalo, Maija Vihinen-Ranta
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010353 (2022)
Autonomous parvoviruses encode at least two nonstructural proteins, NS1 and NS2. While NS1 is linked to important nuclear processes required for viral replication, much less is known about the role of NS2. Specifically, the function of canine parvovi
Externí odkaz:
https://doaj.org/article/7ff487106da443a699fc2c1d82e0fe85
Autor:
Mari Takalo, Juha-Pekka Pursiheimo, Jussi Paananen, Tiina Pirttimäki, Eino Solje, Heikki Tanila, Tuomas Rauramaa, Pasi Miettinen, Sami Gabbouj, Rudolph E. Tanzi, Ville Leinonen, Stina Leskelä, Timo Sarajärvi, Teemu Natunen, Mitja I. Kurki, Mikko Hiltunen, Jayashree Viswanathan, Susanna Kemppainen, Annakaisa Haapasalo, Mikael Marttinen, Eveliina Tahvanainen, Kaisa M.A. Kurkinen, Kari J. Airenne, Hilkka Soininen, Petra Mäkinen
Publikováno v:
Neurobiology of Disease, Vol 85, Iss, Pp 187-205 (2016)
Accumulation of β-amyloid (Aβ) and phosphorylated tau in the brain are central events underlying Alzheimer's disease (AD) pathogenesis. Aβ is generated from amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and γ-secretase-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c72e0865d092c411e96e238f16d6e1
https://doi.org/10.1016/j.nbd.2015.11.005
https://doi.org/10.1016/j.nbd.2015.11.005
Autor:
Kari J. Airenne, Hannu Uusitalo, Hanna P. Lesch, Laura Alasaarela, Kati Kinnunen, T. Tuulos, Emmi Kokki, Giedrius Kalesnykas, Seppo Ylä-Herttuala
Publikováno v:
Current Gene Therapy. 17
Background The eye possesses unique anatomical features that make it a valuable target for gene therapy applications. Objective The aim of the current study was to compare transduction efficiency, safety and biodistribution of four viral vectors foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb4be93a06d4494a1ad6d38d45d011b
https://doi.org/10.2174/1566523217666171003170348
https://doi.org/10.2174/1566523217666171003170348
Publikováno v:
Viruses
Viruses, Vol 7, Iss 4, Pp 2099-2125 (2015)
Viruses, Vol 7, Iss 4, Pp 2099-2125 (2015)
Baculoviruses are widely encountered in nature and a great deal of data is available about their safety and biology. Recently, these versatile, insect-specific viruses have demonstrated their usefulness in various biotechnological applications includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b11091b4ad615f3667fbfebb0b8ed19
https://doi.org/10.3390/v7042099
https://doi.org/10.3390/v7042099
Autor:
Thomas Wirth, Galina Dragneva, Taina Vuorio, Hanna P. Lesch, Jere Pikkarainen, Kari J. Airenne, Ann-Marie Määttä, Hanna Stedt, Seppo Ylä-Herttuala, Haritha Samaranayake
Publikováno v:
Human Gene Therapy. 25:942-954
Malignant gliomas (MGs) are highly vascularized, aggressive brain cancers carrying a dismal prognosis. Because of their high vascularity, anti-angiogenic therapy is a potential treatment option. Indeed, the anti-vascular endothelial growth factor (VE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55734af90f5cacf326b7704c0b02b43e
https://doi.org/10.1089/hum.2013.191
https://doi.org/10.1089/hum.2013.191
Autor:
Kari J. Airenne, Johanna P. Laakkonen, Tytteli Anni Kaarina Turunen, Laura Alasaarela, Seppo Ylä-Herttuala
Publikováno v:
The Journal of Gene Medicine. 16:40-53
Background A baculovirus vector is capable of efficiently transducing many nondiving and diving cell types. However, the potential of baculovirus is restricted for many gene delivery applications as a result of the transient gene expression that it m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45f79a8d7cb2a989b7b86d1be2ebc4fd
https://doi.org/10.1002/jgm.2756
https://doi.org/10.1002/jgm.2756
Autor:
Varpu Marjomäki, Kaisa-Emilia Makkonen, Seppo Ylä-Herttuala, Johanna P. Laakkonen, Kari J. Airenne, Paula Turkki
Publikováno v:
Journal of Virology. 87:11148-11159
Baculoviruses are insect-specific viruses commonly found in nature. They are not able to replicate in mammalian cells but can transduce them when equipped with an appropriate mammalian cell active expression cassette. Although the viruses have been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621a79189bfa563be1a5b771cf4cb6c8
https://doi.org/10.1128/jvi.01919-13
https://doi.org/10.1128/jvi.01919-13