Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Kari I. Kivirikko"'
Autor:
David Sidransky, Barry Trink, Stephen P. Ethier, Kari I. Kivirikko, Joni M. Maki, Junwei Liu, Jatin K. Nagpal, Myoung Sook Kim, Xiaofei Chang, Zhongmin Guo, Guojun Wu
Supplementary Data 1 from LOXL1 and LOXL4 Are Epigenetically Silenced and Can Inhibit Ras/Extracellular Signal-Regulated Kinase Signaling Pathway in Human Bladder Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273f0e2f20ba341d3444b9fe8596edd7
https://doi.org/10.1158/0008-5472.22370414
https://doi.org/10.1158/0008-5472.22370414
Autor:
David Sidransky, Barry Trink, Stephen P. Ethier, Kari I. Kivirikko, Joni M. Maki, Junwei Liu, Jatin K. Nagpal, Myoung Sook Kim, Xiaofei Chang, Zhongmin Guo, Guojun Wu
Promoter hypermethylation is one of the common mechanisms leading to gene silencing in various human cancers. Using a combination of pharmacologic unmasking and microarray techniques, we identified 59 candidate hypermethylated genes, including LOXL1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7610b50b1a6eace10daeb751667716c3
https://doi.org/10.1158/0008-5472.c.6496391
https://doi.org/10.1158/0008-5472.c.6496391
Autor:
Kari I. Kivirikko, Helena Kuivaniemi
Publikováno v:
Connective Tissue Disease ISBN: 9781003210016
Connective Tissue Disease
Connective Tissue Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::041508b65f2785863863fa202cb24064
https://doi.org/10.1201/9781003210016-15
https://doi.org/10.1201/9781003210016-15
Autor:
Jaana Hyvärinen, Marja Pitkänen, Chi Zhang, Antti M. Salo, Raija Sormunen, Päivi Tiainen, Heikki Tanila, Ilkka Miinalainen, Johanna Myllyharju, Henri Leinonen, Ari Koskelainen, Maarit Rossi, Peppi Koivunen, Kari I. Kivirikko, Raija Soininen
Publikováno v:
Human Molecular Genetics. 25:3810-3823
Age-related macular degeneration (AMD), affecting the retinal pigment epithelium (RPE), is the leading cause of blindness in middle-aged and older people in developed countries. Genetic and environmental risk factors have been identified, but no effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3205dbd345ced35a6e594f78f8bf8f49
https://doi.org/10.1093/hmg/ddw228
https://doi.org/10.1093/hmg/ddw228
Autor:
Elitsa Y. Dimova, Gail Walkinshaw, Jukka Hakkola, Helena Gylling, Sohvi Hörkkö, Peppi Koivunen, Lea Rahtu-Korpela, Kari I. Kivirikko, Raisa Serpi, Jenni Määttä, Johanna Myllyharju
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 36(4)
Objective— Small-molecule hypoxia-inducible factor prolyl 4-hydroxylase (HIF-P4H) inhibitors are being explored in clinical studies for the treatment of anemia. HIF-P4H-2 (also known as PHD2 or EglN1) inhibition improves glucose and lipid metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab8d56532f938086213e210c93293f1
https://pubmed.ncbi.nlm.nih.gov/26848160
https://pubmed.ncbi.nlm.nih.gov/26848160
Autor:
Eeva-Riitta Savolainen, Michael P. Arend, Gail Walkinshaw, Maarit Rossi, Minna Heikkilä, Peppi Koivunen, Kari I. Kivirikko, Ellinoora Aro, Johanna Myllyharju, Joni M. Mäki, Anu Laitala
Publikováno v:
Blood. 120:3336-3344
An endoplasmic reticulum transmembrane prolyl 4-hydroxylase (P4H-TM) is able to hydroxylate the α subunit of the hypoxia-inducible factor (HIF) in vitro and in cultured cells, but nothing is known about its roles in mammalian erythropoiesis. We stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b46d2dd7692fdc5aebc0cfda7219e8a
https://doi.org/10.1182/blood-2012-07-441824
https://doi.org/10.1182/blood-2012-07-441824
Publikováno v:
Cellular and Molecular Life Sciences. 68:3885-3901
The hypoxia-inducible transcription factor (HIF) controls (in an oxygen-dependent manner) the expression of a large number of genes whose products are involved in the response of cells to hypoxia. HIF is an αβ dimer that binds to hypoxia response e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13f49ad46ee526bb78985641646d1bd
https://doi.org/10.1007/s00018-011-0679-5
https://doi.org/10.1007/s00018-011-0679-5
Publikováno v:
Nutrition Reviews. 40:306-309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1221a205be03effcb4049437e284b2
https://doi.org/10.1111/j.1753-4887.1982.tb05237.x
https://doi.org/10.1111/j.1753-4887.1982.tb05237.x
Autor:
David Sidransky, Junwei Liu, Guojun Wu, Kari I. Kivirikko, Myoung Sook Kim, Xiaofei Chang, Barry Trink, Joni M. Mäki, Zhongmin Guo, Stephen P. Ethier, Jatin K. Nagpal
Publikováno v:
Cancer Research. 67:4123-4129
Promoter hypermethylation is one of the common mechanisms leading to gene silencing in various human cancers. Using a combination of pharmacologic unmasking and microarray techniques, we identified 59 candidate hypermethylated genes, including LOXL1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117b255f63fc1e85b0a3d39f2345b9fe
https://doi.org/10.1158/0008-5472.can-07-0012
https://doi.org/10.1158/0008-5472.can-07-0012
Autor:
Peppi Koivunen, Kari I. Kivirikko, Maija Hirsilä, Ilmo E. Hassinen, Johanna Myllyharju, Anne M. Remes
Publikováno v:
Journal of Biological Chemistry. 282:4524-4532
The stability and transcriptional activity of the hypoxia-inducible factors (HIFs) are regulated by two oxygen-dependent events that are catalyzed by three HIF prolyl 4-hydroxylases (HIF-P4Hs) and one HIF asparaginyl hydroxylase (FIH). We have studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11a82a542293908ac1ac54204a335621
https://doi.org/10.1074/jbc.m610415200
https://doi.org/10.1074/jbc.m610415200