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CD4 T-cell immune stimulation of HER2 + breast cancer cells alters response to trastuzumab in vitro

Autor: Kari Dugger, Grant Howard, Thomas E. Yankeelov, Anna G. Sorace, Patrick N. Song, Ameer Mansur, Tessa Davis

Publikováno v: Cancer Cell International, Vol 20, Iss 1, Pp 1-11 (2020)
Cancer Cell International

Introduction The HER2 + tumor immune microenvironment is composed of macrophages, natural killer cells, and tumor infiltrating lymphocytes, which produce pro-inflammatory cytokines. Determining the effect of T-cells on HER2 + cancer cells during ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969afd23b69b64e8d2e88cc2d2980b31
https://pubmed.ncbi.nlm.nih.gov/33292267

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Gemcitabine treatment promotes immunosuppressive microenvironment in pancreatic tumors by supporting the infiltration, growth, and polarization of macrophages

Autor: Nikhil Tyagi, Seema Singh, Ahmed Al-Ghadhban, James E. Carter, Mohammad Aslam Khan, Kari Dugger, Ajay P. Singh, Sanjeev K. Srivastava, Sachin Kumar Deshmukh

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)

Chemotherapy-induced immunosuppression poses an additional challenge to its limited efficacy in pancreatic cancer (PC). Here we investigated the effect of gemcitabine on macrophages, which are the first line of immune-defense mechanisms. We observed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63612ae1c64050d249efb42dbe79610
https://doi.org/10.1038/s41598-018-30437-2

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Beta-2 adrenergic receptors increase TREG cell suppression in an OVA-induced allergic asthma mouse model when mice are moderate aerobically exercised

Autor: Sarah Sayner, Kacie Watson, Taylor Chrisman, Kari Dugger, Robert Estes, Parker Chastain

Publikováno v: BMC Immunology
BMC Immunology, Vol 19, Iss 1, Pp 1-13 (2018)

Background The potency of T regulatory (TREG) cells to inhibit T helper (Th)-driven immune cell responses has been linked to increased intracellular cyclic-AMP (cAMP) levels of TREG cells. In an ovalbumin (OVA)-driven allergic asthma mouse model, mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d328021fb2594b929556c6ee5781233
https://doi.org/10.1186/s12865-018-0244-1

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Emerging evidence for the role of differential tumor microenvironment in breast cancer racial disparity: a closer look at the surroundings

Autor: Nikhil Tyagi, Donna Lynn Dyess, Aamir Ahmad, Kari Dugger, James E. Carter, Seema Singh, Sanjeev K. Srivastava, Sachin Kumar Deshmukh, Ajay P. Singh, Ahmed A L Ghadhban

Although increased awareness leading to early detection and prevention, as well as advancements in treatment strategies, have resulted in superior clinical outcomes, African American women with breast cancer continue to have greater mortality rates,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41829b866ce0a55a6be04b28dbc14b74
https://europepmc.org/articles/PMC5862302/

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Abstract 113: Gemcitabine treatment induces immunosuppressive microenvironment in pancreatic cancer by promoting the infiltration, growth, and polarization of macrophages

Autor: Nikhil Tyagi, Kari Dugger, Arun Bhardwaj, Ahmed Al-Ghadhban, Mohammad Aslam Khan, Sachin Kumar Deshmukh, Sanjeev K. Srivastava, James E. Carter, Seema Singh, Ajay P. Singh

Publikováno v: Cancer Research. 78:113-113

Resistance to chemotherapeutic drugs remains a major cause of therapeutic failure in pancreatic cancer (PC) patients. Efficacy of chemotherapy is further limited by its debilitating effects on immune system. Apart from genetic abnormalities in tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccab3ad4d282931e7b7818c7715df21a
https://doi.org/10.1158/1538-7445.am2018-113

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Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma model

Autor: Thomas W. Lowder, Kari Dugger, Jessy S. Deshane, Lisa M. Schwiebert, Kim Estell

Publikováno v: Brain, Behavior, and Immunity. 24:153-159

We have reported previously that moderate intensity aerobic exercise training attenuates airway inflammation in a murine asthma model. Recent studies implicate regulatory T (Treg) cells in decreasing asthma-related airway inflammation; as such, the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1928923f0c1fb500b3c06ea2c592af46
https://doi.org/10.1016/j.bbi.2009.09.011

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Effector and suppressor roles for LFA-1 during the development of experimental autoimmune encephalomyelitis

Autor: Daniel C. Bullard, Scott R. Barnum, Kurt R. Zinn, Casey T. Weaver, Kari Dugger

Publikováno v: Journal of Neuroimmunology. 206:22-27

LFA-1 (CD11a/CD18) is a member of the β 2 -integrin family of adhesion molecules important in leukocyte trafficking and activation. Although LFA-1 is thought to contribute to the development of experimental autoimmune encephalomyelitis (EAE) primari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82837b39b4985959816245d3ac7a8dd
https://doi.org/10.1016/j.jneuroim.2008.10.006

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Noninvasive Bioluminescence Imaging in Small Animals

Autor: Darrell B. O'Quinn, Kurt R. Zinn, Tandra R. Chaudhuri, Xiangdong Wang, April Adams Szafran, Robert A. Kesterson, Stuart J. Frank, Dale Lamar, Casey T. Weaver, Kari Dugger

Publikováno v: ILAR Journal. 49:103-115

There has been a rapid growth of bioluminescence imaging applications in small animal models in recent years, propelled by the availability of instruments, analysis software, reagents, and creative approaches to apply the technology in molecular imag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09fc70810983caeb16eda218570d6b4
https://doi.org/10.1093/ilar.49.1.103

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Imaging CD8+ T cell dynamics in vivo using a transgenic luciferase reporter

Autor: Mitra Azadniv, William J. Bowers, Ian N. Crispe, Kari Dugger, Casey T. Weaver

Publikováno v: International Immunology. 19:1165-1173

After activation, populations of antigen-specific T cells flow between sites of antigen expression, local lymphoid structures and other lymphoid and non-lymphoid organs. In this study, we documented the in vivo dynamics of a CD8(+) T cell response to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ebbcc5357257f187e92655f8bcdabe
https://doi.org/10.1093/intimm/dxm086

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Cutting Edge: Molecular Analysis of the Negative Regulatory Function of Lymphocyte Activation Gene-3

Autor: Kari Dugger, Dario A. A. Vignali, Creg J. Workman

Publikováno v: The Journal of Immunology. 169:5392-5395

Lymphocyte activation gene (LAG)-3 (CD223) is a CD4-related activation-induced cell surface molecule that binds to MHC class II molecules with high affinity and negatively regulates T cell expansion and homeostasis. In this study, we show that LAG-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5632451872a0b0e2afb6964d01457a
https://doi.org/10.4049/jimmunol.169.10.5392

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