Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kari Airenne"'
Autor:
Teemu Natunen, Mari Takalo, Susanna Kemppainen, Stina Leskelä, Mikael Marttinen, Kaisa M.A. Kurkinen, Juha-Pekka Pursiheimo, Timo Sarajärvi, Jayashree Viswanathan, Sami Gabbouj, Eino Solje, Eveliina Tahvanainen, Tiina Pirttimäki, Mitja Kurki, Jussi Paananen, Tuomas Rauramaa, Pasi Miettinen, Petra Mäkinen, Ville Leinonen, Hilkka Soininen, Kari Airenne, Rudolph E. Tanzi, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen
Publikováno v:
Neurobiology of Disease, Vol 85, Iss , Pp 187-205 (2016)
Accumulation of β-amyloid (Aβ) and phosphorylated tau in the brain are central events underlying Alzheimer's disease (AD) pathogenesis. Aβ is generated from amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and γ-secretase-
Externí odkaz:
https://doaj.org/article/fec99dbad77e483d989eaa39ef52f9e5
Publikováno v:
Viruses, Vol 7, Iss 4, Pp 2099-2125 (2015)
Baculoviruses are widely encountered in nature and a great deal of data is available about their safety and biology. Recently, these versatile, insect-specific viruses have demonstrated their usefulness in various biotechnological applications includ
Externí odkaz:
https://doaj.org/article/375cb5ee87654aabaa9ef004e7a994ad
Autor:
Pia Leppänen, Ivana Kholová, Anssi J Mähönen, Kari Airenne, Suvi Koota, Hannu Mansukoski, Johanna Närväinen, Maria Wirzenius, Leena Alhonen, Juhani Jänne, Kari Alitalo, Seppo Ylä-Herttuala
Publikováno v:
PLoS ONE, Vol 1, p e13 (2006)
We have generated a transgenic mouse where hVEGF-A(165) expression has been silenced with loxP-STOP fragment, and we used this model to study the effects of hVEGF-A(165) over-expression in mice after systemic adenovirus mediated Cre-gene transfer. Un
Externí odkaz:
https://doaj.org/article/b3e430171ec14f14a0e0055676d8a8ae
Autor:
Kari Airenne
Publikováno v:
BioProcessing Journal. 8:54-59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c163a9e6a1728860d3b944b3c3bbba0
https://doi.org/10.12665/j83.airenne
https://doi.org/10.12665/j83.airenne
Autor:
Seppo Ylä-Herttuala, Kari Airenne
Publikováno v:
Gene and Cell Therapy ISBN: 9781466571990
Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fourth Edition
Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fourth Edition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a99c8d5f9cca635b070f2cb7012c254d
https://doi.org/10.1201/b18002-11
https://doi.org/10.1201/b18002-11
Autor:
Juhana M. Hakumäki, T. Wirth, Teemu O. Ihalainen, Jani K. Raty, Ale Närvänen, E Hamerlynck, Tuulia Huhtala, Seppo Ylä-Herttuala, Timo Liimatainen, Kari Airenne, Maija Vihinen-Ranta
Publikováno v:
Gene Therapy. 13:1440-1446
We describe here a technique for the visualization of viral vector delivery by magnetic resonance imaging (MRI) in vivo. By conjugating avidin-coated baculoviral vectors (Baavi) with biotinylated ultra-small superparamagnetic iron oxide particles (US
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63d118e084e4d7cb4e7d908e6551002
https://doi.org/10.1038/sj.gt.3302828
https://doi.org/10.1038/sj.gt.3302828
Autor:
Kari Airenne, A K Taskinen, Ari T. Marttila, Michael A. Horton, Lappalainen M, Petri Lehenkari, Varpu Marjomäki, Kalevi J. Pulkkanen, Seppo Ylä-Herttuala, Olli Leppänen, Markku S. Kulomaa, T. Wirth, P. Lehtolainen
Publikováno v:
Gene Therapy. 10:2090-2097
The very high binding affinity of avidin to biotin is one of the highest to occur in nature. We constructed a fusion protein composed of avidin and the endocytotic LDL receptor in order to target biotinylated molecules to cells of the desired tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99c4245f9e3be20fad0ea4ad6ae3eff
https://doi.org/10.1038/sj.gt.3302120
https://doi.org/10.1038/sj.gt.3302120
Autor:
A Laitinen, Cristina Peixoto, Paula M. Alves, Jere Pikkarainen, Seppo Ylä-Herttuala, Haritha Samaranayake, L Laitinen, Hanna P. Lesch, K-E Makkonen, Tiago Vicente, Kari Airenne, Manuel J.T. Carrondo
Publikováno v:
Gene therapy. 18(6)
Lentivirus can be engineered to be a highly potent vector for gene therapy applications. However, generation of clinical grade vectors in enough quantities for therapeutic use is still troublesome and limits the preclinical and clinical experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ac5a48f35f7a714ce093404cd2994b
https://pubmed.ncbi.nlm.nih.gov/21248790
https://pubmed.ncbi.nlm.nih.gov/21248790
Autor:
Miia Taavitsainen, Jani K. Raty, J. J. Pikkarainen, Pasi I Tuunanen, Ale Närvänen, Minna U. Kaikkonen, Kari Airenne, Olli Gröhn, Hanna P. Lesch, Teemu Laitinen, Taina Vuorio, Tuulia Huhtala, Seppo Ylä-Herttuala
Publikováno v:
Gene therapy. 16(7)
Lentiviruses have shown great promise for human gene therapy. However, no optimal strategies are yet available for noninvasive imaging of virus biodistribution and subsequent transduction in vivo. We have developed a dual-imaging strategy based on av
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65bbdb1924567a11ecc7e8d6d25d7c66
https://pubmed.ncbi.nlm.nih.gov/19440224
https://pubmed.ncbi.nlm.nih.gov/19440224