The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme.

Autor: Sbornova I; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., van der Sande E; Department of Ophthalmology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; The Netherlands Institute for Neuroscience (NIN), Royal Dutch Academy of Art & Science (KNAW), Meibergdreef 47, Amsterdam, The Netherlands., Milosavljevic S; Department of Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, Garners Ferry Rd, Columbia, SC., Amurrio E; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., Burbano SD; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., Das P; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., Do H; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., Fisher JL; Department of Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, Garners Ferry Rd, Columbia, SC., Kargbo P; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., Patel J; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., Porcher L; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., De Zeeuw CI; The Netherlands Institute for Neuroscience (NIN), Royal Dutch Academy of Art & Science (KNAW), Meibergdreef 47, Amsterdam, The Netherlands.; Department of Neuroscience, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands., Meester-Smoor MA; Department of Ophthalmology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands., Winkelman BHJ; Department of Ophthalmology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; The Netherlands Institute for Neuroscience (NIN), Royal Dutch Academy of Art & Science (KNAW), Meibergdreef 47, Amsterdam, The Netherlands.; Department of Neuroscience, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands., Klaver CCW; Department of Ophthalmology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; Department of Ophthalmology, Radboud University Medical Center, Geert Grooteplein Zuid 10, Nijmegen, The Netherlands.; Institute of Molecular and Clinical Ophthalmology, Mittlere Strasse 91, Basel, Switzerland., Pocivavsek A; Department of Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, Garners Ferry Rd, Columbia, SC., Kelly MP; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.; Center for Research on Aging, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 17. Date of Electronic Publication: 2023 Nov 17.