Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Karen-Amanda Irvine"'
Autor:
Derek Allen, Samerender Nagam Hanumantharao, Rylie McDonell, Karen-Amanda Irvine, Peyman Sahbaie, David Clark, Paul Blum
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Inhibition of actin remodeling in nerves modulates action potential propagation and therefore could be used to treat acute pain. N-001 is a novel protein analgesic engineered from several C. Botulinum toxins. N-001 targets sensory neurons th
Externí odkaz:
https://doaj.org/article/6cc6ad02dc2144f8b85f8619a02a08b3
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Traumatic brain injury (TBI) is a significant public health concern, with the majority of injuries being mild. Many TBI victims experience chronic pain. Unfortunately, the mechanisms underlying pain after TBI are poorly understood. Here we e
Externí odkaz:
https://doaj.org/article/9dda386573334158bb375fd9f4bebcc4
Autor:
Robin Bishop, Seok Joon Won, Karen-Amanda Irvine, Jayinee Basu, Eric S. Rome, Raymond A. Swanson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Blast exposure can injure brain by multiple mechanisms, and injury attributable to direct effects of the blast wave itself have been difficult to distinguish from that caused by rapid head displacement and other secondary processes. To resol
Externí odkaz:
https://doaj.org/article/d974a4b5dd7d4563a28d7a806bc0cb84
Autor:
De-Yong Liang, Peyman Sahbaie, Yuan Sun, Karen-Amanda Irvine, Xiaoyou Shi, Anders Meidahl, Peng Liu, Tian-Zhi Guo, David C. Yeomans, J. David Clark
Publikováno v:
IBRO Reports, Vol 2, Iss C, Pp 14-23 (2017)
Chronic pain after traumatic brain injury (TBI) is very common, but the mechanisms linking TBI to pain and the pain-related interactions of TBI with peripheral injuries are poorly understood. In these studies we pursued the hypothesis that TBI pain s
Externí odkaz:
https://doaj.org/article/79217afe64ec488693660395cf4b7b7d
Autor:
Adam R Ferguson, Karen-Amanda Irvine, John C Gensel, Jessica L Nielson, Amity Lin, Johnathan Ly, Mark R Segal, Rajiv R Ratan, Jacqueline C Bresnahan, Michael S Beattie
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59712 (2013)
Spinal cord injury (SCI) and other neurological disorders involve complex biological and functional changes. Well-characterized preclinical models provide a powerful tool for understanding mechanisms of disease; however managing information produced
Externí odkaz:
https://doaj.org/article/9a4b4863850949e6bf582f619bc8828f
Publikováno v:
Anesthesia & Analgesia.
Autor:
Seok Joon Won, Jayinee Basu, Karen-Amanda Irvine, Robin K Bishop, Raymond A. Swanson, Eric Rome
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Scientific reports, vol 12, iss 1
Scientific Reports
Scientific reports, vol 12, iss 1
Scientific Reports
Blast exposure can injure brain by multiple mechanisms, and injury attributable to direct effects of the blast wave itself have been difficult to distinguish from that caused by rapid head displacement and other secondary processes. To resolve this i
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
High rates of acute and chronic pain are associated with traumatic brain injury (TBI), but mechanisms responsible for the association remain elusive. Recent data suggest dysregulated descending pain modulation circuitry could be involved. Based on th
Autor:
Nikos Kyritsis, Jacqueline C. Bresnahan, Karen-Amanda Irvine, John C. Gensel, Rajiv R. Ratan, Jessica L. Nielson, Michael C. Oldham, J.R. Huie, Mark R. Segal, Michael S. Beattie, Jonathan Z. Pan, Amity Lin, Adam R. Ferguson, Patrick G. Schupp
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
SUMMARYTraumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d88e3e42b981826baf038dde7aa4fd2
https://escholarship.org/uc/item/75d653j4
https://escholarship.org/uc/item/75d653j4
Autor:
Karen-Amanda Irvine, Wen-Wu Li, Vivianne L. Tawfik, Xiaoyou Shi, J. David Clark, Tian-Zhi Guo, Peyman Sahbaie, Wade S. Kingery
Publikováno v:
Anesthesiology. 130:292-308
Editor’s PerspectiveWhat We Already Know about This TopicWhat This Article Tells Us That Is NewBackgroundEmerging evidence suggests that opioid use immediately after surgery and trauma may worsen outcomes. In these studies, the authors aimed to det