Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Karen Yap"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-33 (2024)
Abstract Background The functional coupling between alternative pre-mRNA splicing (AS) and the mRNA quality control mechanism called nonsense-mediated decay (NMD) can modulate transcript abundance. Previous studies have identified several examples of
Externí odkaz:
https://doaj.org/article/23d3ae8bceac433f8af4c11f5f4b0477
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101139- (2022)
Summary: This protocol describes a hybridization-proximity labeling (HyPro) approach for identification of proteins and RNAs co-localizing with a transcript of interest in genetically unperturbed cells. It outlines steps required for purification of
Externí odkaz:
https://doaj.org/article/72adea887250492d86e74701ba9d0ab9
Publikováno v:
Cell Reports, Vol 15, Iss 6, Pp 1316-1328 (2016)
Alternative splicing (AS) is an important source of proteome diversity in eukaryotes. However, how this affects protein repertoires at a single-cell level remains an open question. Here, we show that many 3′-terminal exons are persistently co-expre
Externí odkaz:
https://doaj.org/article/d02823d806914d94b904393ed9d8ef92
Autor:
Jens Verbeeren, Bhupendra Verma, Elina H Niemelä, Karen Yap, Eugene V Makeyev, Mikko J Frilander
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006824 (2017)
Cellular homeostasis of the minor spliceosome is regulated by a negative feed-back loop that targets U11-48K and U11/U12-65K mRNAs encoding essential components of the U12-type intron-specific U11/U12 di-snRNP. This involves interaction of the U11 sn
Externí odkaz:
https://doaj.org/article/db1e852f794c46a88539e4da8f25ae15
Publikováno v:
Molecular Cell
Summary The ability of RNAs to form specific contacts with other macromolecules provides an important mechanism for subcellular compartmentalization. Here we describe a suite of hybridization-proximity (HyPro) labeling technologies for unbiased disco
Autor:
Karen Yap, Jens Verbeeren, Mikko J. Frilander, Elina H. Niemelä, Evgeniy V. Makeyev, Bhupendra Verma
Publikováno v:
Verbeeren, J, Verma, B, Niemelä, E H, Yap, K, Makeyev, E V & Frilander, M J 2017, ' Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA ', PL o S Genetics, vol. 13, no. 5, e1006824 . https://doi.org/10.1371/journal.pgen.1006824
PLoS Genetics
PLoS Genetics, Vol 13, Iss 5, p e1006824 (2017)
PLoS Genetics
PLoS Genetics, Vol 13, Iss 5, p e1006824 (2017)
Cellular homeostasis of the minor spliceosome is regulated by a negative feed-back loop that targets U11-48K and U11/U12-65K mRNAs encoding essential components of the U12-type intron-specific U11/U12 di-snRNP. This involves interaction of the U11 sn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b710068dc94d24890d32f6fab04183
http://hdl.handle.net/10138/199224
http://hdl.handle.net/10138/199224
Autor:
Stephanie Fook-Chong, Karen Yap, Yi Zhao, F. Shaffra Refai, Patrick Ho, Mobin Siddique, Eng-King Tan
Publikováno v:
Human Mutation. 30:1551-1557
Mutations in the gene encoding phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) have been associated with the loss of dopaminergic neurons characteristic of familial and sporadic Parkinson disease. We developed an in vitro system of sta
Publikováno v:
Microsurgery. 24:304-308
The aim of this study was to establish the long-term biomechanical and histological properties of 2-octylcyanoacrylate-assisted microvascular anastomosis over conventional suture-only anastomosis in the laboratory rat model. The biomechanical and his
Autor:
Hazel Lavina A. Lickley, Karen Yap, David R. McCready, Judy-Anne W. Chapman, Harriette J. Kahn, E.B. Fish, Wedad Hanna
Publikováno v:
Annals of Surgical Oncology. 7:562-567
We have been following a cohort of patients who underwent a lumpectomy without receiving adjuvant radiotherapy or adjuvant systemic therapy. We now report the experience of a postmenopausal subgroup.The postmenopausal subgroup included 244 patients a
Autor:
Eugene V. Makeyev, Karen Yap
Publikováno v:
Molecular and cellular neurosciences. 56
Eukaryotic gene expression is orchestrated on a genome-wide scale through several post-transcriptional mechanisms. Of these, alternative pre-mRNA splicing expands the proteome diversity and modulates mRNA stability through downstream RNA quality cont