Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Karen Y, Torrejon"'
Autor:
Luke A. Beardslee, Justin R. Halman, Andrea M. Unser, Yubing Xie, John Danias, Magnus Bergkvist, Susan T. Sharfstein, Karen Y. Torrejon
Publikováno v:
Bioengineering, Vol 10, Iss 6, p 679 (2023)
Glaucoma, where increased intraocular pressure (IOP) leads to damage to the optic nerve and loss of sight, is amongst the foremost causes of irreversible blindness worldwide. In primary open angle glaucoma, the increased IOP is a result of the malfun
Externí odkaz:
https://doaj.org/article/38449f1b15ad45ebbfdf69d459201dcb
Autor:
Colleen M. McDowell, Krishnakumar Kizhatil, Michael H. Elliott, Darryl R. Overby, Joseph van Batenburg-Sherwood, J. Cameron Millar, Markus H. Kuehn, Gulab Zode, Ted S. Acott, Michael G. Anderson, Sanjoy K. Bhattacharya, Jacques A. Bertrand, Terete Borras, Diane E. Bovenkamp, Lin Cheng, John Danias, Michael Lucio De Ieso, Yiqin Du, Jennifer A. Faralli, Rudolf Fuchshofer, Preethi S. Ganapathy, Haiyan Gong, Samuel Herberg, Humberto Hernandez, Peter Humphries, Simon W. M. John, Paul L. Kaufman, Kate E. Keller, Mary J. Kelley, Ruth A. Kelly, David Krizaj, Ajay Kumar, Brian C. Leonard, Raquel L. Lieberman, Paloma Liton, Yutao Liu, Katy C. Liu, Navita N. Lopez, Weiming Mao, Timur Mavlyutov, Fiona McDonnell, Gillian J. McLellan, Philip Mzyk, Andrews Nartey, Louis R. Pasquale, Gaurang C. Patel, Padmanabhan P. Pattabiraman, Donna M. Peters, Vijaykrishna Raghunathan, Ponugoti Vasantha Rao, Naga Rayana, Urmimala Raychaudhuri, Ester Reina-Torres, Ruiyi Ren, Douglas Rhee, Uttio Roy Chowdhury, John R. Samples, E. Griffen Samples, Najam Sharif, Joel S. Schuman, Val C. Sheffield, Cooper H. Stevenson, Avinash Soundararajan, Preeti Subramanian, Chenna Kesavulu Sugali, Yang Sun, Carol B. Toris, Karen Y. Torrejon, Amir Vahabikashi, Janice A. Vranka, Ting Wang, Colin E. Willoughby, Chen Xin, Hongmin Yun, Hao F. Zhang, Michael P. Fautsch, Ernst R. Tamm, Abbot F. Clark, C. Ross Ethier, W. Daniel Stamer
Publikováno v:
Investigative ophthalmology & visual science, vol 63, iss 2
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models
Publikováno v:
Adv Biosyst
Age-related human trabecular meshwork (HTM) cell loss is suggested to affect its ability to regulate aqueous humor outflow in the eye. In addition, disease-related HTM cell loss is suggested to lead to elevated intraocular pressure in glaucoma. Induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ed47d0f6a06479a887a9a391dc6baf
https://europepmc.org/articles/PMC7484422/
https://europepmc.org/articles/PMC7484422/
Autor:
John Danias, Yubing Xie, Yiqin Du, Xulang Zhang, Yangzi Isabel Tian, Karen Y. Torrejon, Ashima Nayyar, Sofya Gindina
Publikováno v:
Acta Biomater
Human Schlemm's canal (HSC) cells are critical for understanding outflow physiology and glaucoma etiology. However, primary donor cells frequently used in research are difficult to isolate. HSC cells exhibit both vascular and lymphatic markers. Human
Autor:
Susan T. Sharfstein, Justin R. Halman, Yubing Xie, John Danias, Judith A. Stolwijk, Karen Y. Torrejon, Ellen L. Papke, Magnus Bergkvist, Cula N. Dautriche
Publikováno v:
Biotechnology and Bioengineering. 113:1357-1368
Intraocular pressure (IOP) is mostly regulated by aqueous humor outflow through the human trabecular meshwork (HTM) and represents the only modifiable risk factor of glaucoma. The lack of IOP-modulating therapeutics that targets HTM underscores the n
Autor:
Evan B. Stubbs, Thomas F. Freddo, Paul L. Kaufman, Elke Lütjen-Drecoll, Markus H. Kuehn, Theresa Borrás, Janice A. Vranka, Michael P. Fautsch, Casey Kopczynski, Karen Y. Torrejon, Paul A. Knepper, Raquel L. Lieberman, Alex S. Huang, James C. Tan, Mary K. Wirtz, Ernst R. Tamm, Padmanabhan P. Pattabiraman, Carol B. Toris, W. Daniel Stamer, Douglas J Rhee, Ted S. Acott, Murray A. Johnstone, Shan C. Lin, Sanjoy K. Bhattacharya, Kate E. Keller, Colleen M McDowell, Jie Zhang, Weiming Mao, C. Ross Ethier, Michael H. Elliott, Marisse Masis-Solano, Rudolf Fuchshofer, P. Vasanth Rao, Yutao Liu, Fiona McDonnell, Yiqin Du, Michael Giovingo, Rachel W. Kuchtey, Darryl R. Overby, Thomas Yorio, Vijay Krishna Raghunathan, Donald Schwartz, Donna M. Peters, Paul Russell, John R. Samples, Sunee Chansangpetch, Uttio Roy Chowdhury, Pedro Gonzalez, Gulab Zode, Paloma B. Liton, John Kuchtey, Mary J. Kelley, W. Michael Dismuke, Haiyan Gong, Thomas M. Brunner, Abbott F. Clark, Jennifer A. Faralli
Publikováno v:
Experimental eye research. 171
Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular mechanisms involved in the regulation of conventional outflow resistance and thus intraocular pressure; and their dysfunction resulting in ocular hypertension.
Autor:
Justin R. Halman, Susan T. Sharfstein, Magnus Bergkvist, Ellen L. Papke, John Danias, Karen Y. Torrejon, Yubing Xie
Publikováno v:
Scientific Reports
Members of the transforming growth factor beta (TGFβ) cytokine family have long been associated with affecting several cellular functions, including cell proliferation, differentiation and extracellular matrix (ECM) turnover. Of particular interest
Publikováno v:
Biotechnology and Bioengineering. 110:3205-3218
Glaucoma is the leading cause of irreversible blindness, resulting from an increase in intraocular pressure (IOP). IOP is the only modifiable risk factor of glaucoma and is controlled by the outflow of the aqueous humor through the human trabecular m
Autor:
Monika Lakk, Balamurali K. Ambati, Gregory S. Hageman, Andrew Jo, Karen Y. Torrejon, Daniel A. Ryskamp, Anthony Iuso, Amber M. Frye, David Križaj, Yong Xu, Oleg Yarishkin, Tam T. T. Phuong, Sarah Redmon, Glenn D. Prestwich
Publikováno v:
Scientific Reports
An intractable challenge in glaucoma treatment has been to identify druggable targets within the conventional aqueous humor outflow pathway, which is thought to be regulated/dysregulated by elusive mechanosensitive protein(s). Here, biochemical and f
Autor:
Karen Y, Torrejon, Ellen L, Papke, Justin R, Halman, Judith, Stolwijk, Cula N, Dautriche, Magnus, Bergkvist, John, Danias, Susan T, Sharfstein, Yubing, Xie
Publikováno v:
Biotechnology and bioengineering. 113(6)
Intraocular pressure (IOP) is mostly regulated by aqueous humor outflow through the human trabecular meshwork (HTM) and represents the only modifiable risk factor of glaucoma. The lack of IOP-modulating therapeutics that targets HTM underscores the n