Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Karen X. Ye"'
Autor:
Yiyuan Xia, Hiroshi Qadota, Zhi-Hao Wang, Pai Liu, Xia Liu, Karen X. Ye, Courtney J. Matheny, Ken Berglund, Shan Ping Yu, Derek Drake, David A. Bennett, Xiao-Chuan Wang, Bruce A. Yankner, Guy M. Benian, Keqiang Ye
Publikováno v:
Science Advances. 8
The age-related cognitive decline of normal aging is exacerbated in neurodegenerative diseases including Alzheimer’s disease (AD). However, it remains unclear whether age-related cognitive regulators in AD pathologies contribute to life span. Here,
Autor:
Yiyuan Xia, Zhi-Hao Wang, Karen X Ye, Keqiang Ye, Xia Liu, Xiaochuan Wang, Shan Ping Yu, Jian-Zhi Wang, Jichun Zhang
Publikováno v:
Mol Psychiatry
The apolipoprotein E ε4 (APOE4) allele is a major genetic risk factor for Alzheimer’s disease (AD), and its protein product, ApoE4, exerts its deleterious effects mainly by influencing amyloid-β (Aβ) and Tau (neurofibrillary tangles, NFTs) depos