Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Karen Wigglesworth"'
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7479 (2009)
Gene expression microarrays have provided many insights into changes in gene expression patterns between different tissue types, developmental stages, and disease states. Analyses of these data focused primarily measuring the relative abundance of tr
Externí odkaz:
https://doaj.org/article/eff0193497d3460392f3a5441e0759e3
Publikováno v:
Endocrinology. 154:4859-4872
Oocyte-derived paracrine factors (ODPFs) and estrogens are both essential for the development and function of ovarian follicles in mammals. Cooperation of these two factors was assessed in vitro using intact cumulus-oocyte complexes, cumulus cells cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02405513178554dc0b7ca825609bf4d
https://doi.org/10.1210/en.2013-1536
https://doi.org/10.1210/en.2013-1536
Publikováno v:
Molecular Endocrinology. 24:2303-2314
The differentiation and function of cumulus cells depend upon oocyte-derived paracrine factors, but studies on the estrogen receptor knockout mice suggested that estrogen also participates in these processes. This study investigates the possible coor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee99274113762dea548b32009a89144
https://doi.org/10.1210/me.2010-0260
https://doi.org/10.1210/me.2010-0260
Publikováno v:
Biology of Reproduction. 81:833-841
Mouse oocytes produce members of the transforming growth factor beta (TGFbeta) superfamily, including bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), as well as fibroblast growth factors (FGFs). These growth factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05985401d49fbcce41c5fc82486a66d2
https://doi.org/10.1095/biolreprod.109.078485
https://doi.org/10.1095/biolreprod.109.078485
Autor:
Suzanne Hartford, Kerry J. Schimenti, Dana L. Philipps, John J. Eppig, Shrivatsav Pattabiraman, Fengyun Sun, John C. Schimenti, Mary Ann Handel, Karen Wigglesworth
Publikováno v:
Developmental Biology. 317:72-82
A novel mutation, repro5, was isolated in a forward genetic screen for infertility mutations induced by ENU mutagenesis. Homozygous mutant mice were phenotypically normal but were infertile. Oocytes from mutant females appeared normal, but were sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e886fd1f13d839613822e2c622b191
https://doi.org/10.1016/j.ydbio.2008.02.018
https://doi.org/10.1016/j.ydbio.2008.02.018
Autor:
You-Qiang Su, Karen Wigglesworth, Shweta Sharma, John J. Eppig, Francisco J. Diaz, Marilyn J. O'Brien, Stephanie A. Pangas, Shunichi Shimasaki, Martin M. Matzuk, Koji Sugiura
Publikováno v:
Development. 134:2593-2603
Mammalian oocytes are deficient in their ability to carry out glycolysis. Therefore, the products of glycolysis that are necessary for oocyte development are provided to oocytes by companion cumulus cells. Mouse oocytes secrete paracrine factors that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4189312bba3babef53c4669721d5d215
https://doi.org/10.1242/dev.006882
https://doi.org/10.1242/dev.006882
Publikováno v:
Developmental Biology. 305:300-311
Preantral granulosa cells (PAGCs) differentiate into cumulus cells following antrum formation. Cumulus cells, but not PAGCs, are competent to undergo expansion. Experiments reported here tested the respective roles of both oocytes and FSH in the tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836eb89c90754552958253b725b332e1
https://doi.org/10.1016/j.ydbio.2007.02.019
https://doi.org/10.1016/j.ydbio.2007.02.019
Publikováno v:
Biology of Reproduction. 92
Cumulus cells and mural granulosa cells (MGCs) have functionally distinct roles in antral follicles, and comparison of their transcriptomes at a global and systems level can propel future studies on mechanisms underlying their functional diversity. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe6dfc43da9ba328fa6f974ce2f625f7
https://doi.org/10.1095/biolreprod.114.121756
https://doi.org/10.1095/biolreprod.114.121756
Publikováno v:
Developmental Biology. 299:91-104
The transition of preantral to antral follicles is one of the major steps in follicular development, yet little is known about the molecular and functional changes that occur as preantral granulosa cells differentiate into cumulus cells. The cumulus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c12eacb018994b94917f1619c50ea1b
https://doi.org/10.1016/j.ydbio.2006.07.012
https://doi.org/10.1016/j.ydbio.2006.07.012
Autor:
Thomas B. Thompson, Adithya Rangarajan, Jia Peng, John J. Eppig, Martin M. Matzuk, Karen Wigglesworth
Publikováno v:
Biology of Reproduction. 91
Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are oocyte-secreted paralogs of the transforming growth factor beta (TGFbeta) superfamily. In mammals, these two growth factors play critical roles in folliculogenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbcdf3032b11d1853a89b7d63a176c5
https://doi.org/10.1095/biolreprod.114.123158
https://doi.org/10.1095/biolreprod.114.123158