Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Karen Walters"'
Autor:
Nasir Khan, Martin Finkelstein, Hans-Peter Gerber, Richard Giovanelli, Sharon Sokolowski, Chunli Huang, Danielle Sullivan, William Reagan, Timothy Coskran, Germaine Boucher, Richard Goldstein, Karen Walters, Leslie Obert, John Kreeger, Kathleen Biddle, Hadi Falahatpisheh, Magali Guffroy
Legends of supplementary figures 1, 2 and 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbf035dae9167ca70ae2357d0baa953
https://doi.org/10.1158/1078-0432.22465505
https://doi.org/10.1158/1078-0432.22465505
Autor:
Nasir Khan, Martin Finkelstein, Hans-Peter Gerber, Richard Giovanelli, Sharon Sokolowski, Chunli Huang, Danielle Sullivan, William Reagan, Timothy Coskran, Germaine Boucher, Richard Goldstein, Karen Walters, Leslie Obert, John Kreeger, Kathleen Biddle, Hadi Falahatpisheh, Magali Guffroy
There were no significant PF-0259-related changes in IL-6 throughout the study. Data are represented as mean ratios to baseline {plus minus} 1 standard deviation (SD).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4523f4e1f2d816c34671e67e6877ac
https://doi.org/10.1158/1078-0432.22465496.v1
https://doi.org/10.1158/1078-0432.22465496.v1
Autor:
Nasir Khan, Martin Finkelstein, Hans-Peter Gerber, Richard Giovanelli, Sharon Sokolowski, Chunli Huang, Danielle Sullivan, William Reagan, Timothy Coskran, Germaine Boucher, Richard Goldstein, Karen Walters, Leslie Obert, John Kreeger, Kathleen Biddle, Hadi Falahatpisheh, Magali Guffroy
PF-0259 did not induce platelet sequestration in spleen. Monkeys were dosed intravenously with vehicle or PF-0259 at 6 mg/m2/dose once every 3 weeks and were necropsied on Day 3 (at the time of platelet nadirs) or on Day 63 (at the end of the 3rd cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c80e160deb6d6434747f378503ea81
https://doi.org/10.1158/1078-0432.22465499.v1
https://doi.org/10.1158/1078-0432.22465499.v1
Autor:
Nasir Khan, Martin Finkelstein, Hans-Peter Gerber, Richard Giovanelli, Sharon Sokolowski, Chunli Huang, Danielle Sullivan, William Reagan, Timothy Coskran, Germaine Boucher, Richard Goldstein, Karen Walters, Leslie Obert, John Kreeger, Kathleen Biddle, Hadi Falahatpisheh, Magali Guffroy
PF-0259 did not induce platelet sequestration in kidney or lung. Monkeys were necropsied 48 hours after a single intravenous administration of vehicle or PF-0259 at 6 mg/m2. CD41 IHC for platelets was performed on kidney and lung samples from vehicle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f6476874c45a0d82ba4f2108f1dee9
https://doi.org/10.1158/1078-0432.22465502.v1
https://doi.org/10.1158/1078-0432.22465502.v1
Autor:
Jean G. Sathish, Siddhartha Bhatt, Jamie K. DaSilva, Declan Flynn, Stephen Jenkinson, Amit S. Kalgutkar, Maggie Liu, Balasubramanian Manickam, Jason Pinkstaff, William J. Reagan, Norimitsu Shirai, Ahmed M. Shoieb, Madhu Sirivelu, Saurabh Vispute, Allison Vitsky, Karen Walters, Todd A. Wisialowski, Lawrence W. Updyke
Publikováno v:
International journal of toxicology. 41(4)
COVID-19 is a potentially fatal infection caused by the SARS-CoV-2 virus. The SARS-CoV-2 3CL protease (Mpro) is a viral enzyme essential for replication and is the target for nirmatrelvir. Paxlovid (nirmatrelvir co-administered with the pharmacokinet
Autor:
Magalie Boucher, Karen Walters, Casey Ritenour, Hayley N Pryski, Alan C. Opsahl, Christopher Somps, Peter R. Mouton, Chang-Ning Liu, Thomas T. Kawabe, Germaine Boucher
Publikováno v:
Toxicologic Pathology. 48:228-237
The potential for neurogenesis in the cranial (superior) cervical ganglia (SCG) of the sympathetic nervous system was evaluated. Eleven consecutive daily doses of guanethidine (100 mg/kg/d) were administered intraperitoneally to rats in order to dest
Autor:
Hans-Peter Gerber, Chunli Huang, Leslie A. Obert, Magali Guffroy, Germaine Boucher, Richard Goldstein, Karen Walters, Danielle Sullivan, Hadi Falahatpisheh, William J. Reagan, John M. Kreeger, Nasir K. Khan, Tim M. Coskran, Kathleen Biddle, Richard P. Giovanelli, Sharon A. Sokolowski, Martin Finkelstein
Publikováno v:
Clinical Cancer Research. 23:1760-1770
Purpose: Adverse reactions reported in patients treated with antibody–calicheamicin conjugates such as gemtuzumab ozogamicin (Mylotarg) and inotuzumab ozogamicin include thrombocytopenia and sinusoidal obstruction syndrome (SOS). The objective of t
Autor:
Roberto A. Calle, Danna M. Breen, Susie Collins, Hanna Kim, Shuxi Qiao, Alison Joyce, Bei B. Zhang, Kevin Beaumont, Michelle Rossulek, Laura Lin, Julia Brosnan, Brendan Tierney, Morris J. Birnbaum, Betty Pettersen, Donald Bennett, Zhidan Wu, Ryan M. Esquejo, Gregory Weber, Karen Walters, Stephanie Joaquim, Teresa Cunio, Jeffrey R. Chabot
Publikováno v:
Cancer Research. 80:3056-3056
Platinum-based chemotherapy is associated with nausea/emesis, anorexia and weight loss which reduce patient quality of life and limit treatment adherence potentially leading to poor treatment outcomes. Cisplatin increases circulating growth different
Autor:
Angela Wolford, Heather Eng, Yanwei Zhang, Suvi T. M. Orr, Kay Ahn, Daniel W. Widlicka, Carlin Okerberg, Amit S. Kalgutkar, Yingmei Qi, Samantha N. Spath, Paul D. Bonin, Dilinie P. Fernando, Aaron C. Smith, Tim F. Ryder, Karen Walters, Yan Zhang, David Hepworth, Wenhua Jiao, Joseph S. Warmus, Benjamin N. Rocke, Tristan S. Maurer, Daniel Merritt Bowles, Daniel W. Kung, Scott W. Bagley, Philip A. Carpino, Roger B. Ruggeri, Gang Xing, Leonard Buckbinder, Edward L. Conn, Matthew S. Dowling, Raman Sharma
Publikováno v:
Journal of Medicinal Chemistry. 58:8513-8528
Myeloperoxidase (MPO) is a heme peroxidase that catalyzes the production of hypochlorous acid. Clinical evidence suggests a causal role for MPO in various autoimmune and inflammatory disorders including vasculitis and cardiovascular and Parkinson's d
Autor:
Jack J. Kinsora, N. Suman-Chauhan, Clare O. Kneen, Karen Walters, Cindy M. Donovan, David J. Wustrow, Thomas Capiris, David J. Dooley, Ayman El-Kattan, Mark G. Vartanian, Lisa R. Thompson, Susan M. Lotarski, Simon A. Osborne, Jacob Bradley Schwarz, Mark J. Field, Carmen E. Burgos-Lepley, Charles Taylor, Justin Stephen Bryans, Madhu Cherukury
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2333-2336
A series of carboxylate bioisosteres of structures related to gabapentin 1 have been prepared. When the carboxylate was replaced by a tetrazole, this group was recognized by the alpha2-delta protein. Further characterization of alpha2-delta binding c