Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Karen Wager-Smith"'
Autor:
Karen Wager-Smith, Athina Markou
Publikováno v:
Neuroscience & Biobehavioral Reviews. 35:742-764
Depression is a major contributor to the global burden of disease and disability, yet it is poorly understood. Here we review data supporting a novel theoretical model for the biology of depression. In this model, a stressful life event leads to micr
Autor:
Karen Wager-Smith, Steve A. Kay
Publikováno v:
Nature Genetics. 26:23-27
A successful genetic dissection of the circadian regulation of behaviour has been achieved through phenotype-driven mutagenesis screens in flies and mice. Cloning and biochemical analysis of these evolutionarily conserved proteins has led to detailed
Autor:
Thomas D.L. Steeves, David Staknis, Karen Wager-Smith, Charles J. Weitz, Joseph S. Takahashi, Thomas K. Darlington, Nicholas Gekakis, Steve A. Kay, M. Fernanda Ceriani
Publikováno v:
Science. 280:1599-1603
The circadian oscillator generates a rhythmic output with a period of about 24 hours. Despite extensive studies in several model systems, the biochemical mode of action has not yet been demonstrated for any of its components. Here, the Drosophila CLO
Publikováno v:
Science. 270:805-808
The Drosophila genes timeless (tim) and period (per) interact, and both are required for production of circadian rhythms. Here the positional cloning and sequencing of tim are reported. The tim gene encodes a previously uncharacterized protein of 138
Publikováno v:
Journal of Biological Chemistry. 270:4753-4758
The 28-kilodalton (kDa) catalytic domain of the human cytomegalovirus (HCMV) protease undergoes autoproteolytic cleavage at an internal site (I site), yielding amino-terminal 15-kDa (N15) and carboxyl-terminal 13-kDa (C13) fragments. I site autocleav
Autor:
Karen Wager-Smith, Michael Rosbash, Ralf Stanewsky, Jeffrey C. Hall, Patrick Emery, Steve A. Kay, Maki Kaneko, Bonnie Beretta
Publikováno v:
Cell. 95(5)
A new rhythm mutation was isolated based on its elimination of per-controlled luciferase cycling. Levels of period or timeless clock gene products in the mutant are flat in daily light–dark cycles or constant darkness (although PER and TIM oscillat
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 1998, 95 (11), pp.5884-5890. ⟨10.1073/pnas.95.11.5884⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 1998, 95 (11), pp.5884-5890. ⟨10.1073/pnas.95.11.5884⟩
PAS domains are found in diverse proteins throughout all three kingdoms of life, where they apparently function in sensing and signal transduction. Although a wealth of useful sequence and functional information has become recently available, these d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f8aa76d3c6c61e6cbc93937c96eb70
https://hal.archives-ouvertes.fr/hal-03274011
https://hal.archives-ouvertes.fr/hal-03274011
Autor:
Kelly A. Combs, Beverly Ricci, Cleris M. Gil, Marie-Elizabeth Boumas, Richard E. Gregg, Daniel J. Rader, John R. Wetterau, Laura Blinderman, David A. Gordon, Lawrence P. Aggerbeck, Karen Wager-Smith, Sharp Daru Young, Bernadette Kienzle, Christoph W. Turck
Publikováno v:
Nature. 365(6441)
The microsomal triglyceride transfer protein (MTP), which catalyses the transport of triglyceride, cholesteryl ester and phospholipid between phospholipid surfaces, is a heterodimer composed of the multifunctional protein, protein disulphide isomeras
Autor:
J. David Sweatt, Karen Wager-Smith, Ari Barzilai, Kevin A. Karl, Mary Ann Gawinowicz, Eric R. Kandel, Timothy E. Kennedy
Publikováno v:
Electrophoresis. 10:152-157
As part of our continuing studies into the biochemical basis of long-term changes in neuronal function in Aplysia, we have developed a simple method for obtaining amino acid sequence information from proteins isolated on two-dimensional gels. Protein
Autor:
John W. Belmont, Grant R. MacGregor, Karen Wager-Smith, Fred A. Fletcher, Kateri A. Moore, Dianne Hawkins, Deborah Villalon, Steve M.-W. Chang, C. Thomas Caskey
Publikováno v:
Molecular and cellular biology. 8(12)
Multiple replication-defective retrovirus vectors were tested for their ability to transfer and express human adenosine deaminase in vitro and in vivo in a mouse bone marrow transplantation model. High-titer virus production was obtained from vectors