Výsledky vyhledávání - "Karen W. Muszynski"

Attenuation of Neurovirulence, Biodistribution, and Shedding of a Poliovirus:Rhinovirus Chimera after Intrathalamic Inoculation in Macaca fascicularis

Autor: Karyol Poole, Sheryl Ruppel, Matthias Gromeier, Sarah K. Lawson, Christian Goetz, James O. Peggins, Robert W. Walters, Karen W. Muszynski, Elena Y. Dobrikova, James E. Estep, Steven L. Giardina, Eric M. Vela

Publikováno v: Journal of Virology. 86:2750-2759

A dependence of poliovirus on an unorthodox translation initiation mode can be targeted selectively to drive viral protein synthesis and cytotoxicity in malignant cells. Transformed cells are naturally susceptible to poliovirus, due to widespread ect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5adbd1e391ce292474c40fe8a81184c
https://doi.org/10.1128/jvi.06427-11

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Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay

Autor: Karen W. Muszynski, Hengguang Jiang, Gopalan Soman, Matthias Gromeier, Steven L. Giardina, Eying Chen, Gautam Mitra, Raymond D. Harris, Xiaoyi Yang

Publikováno v: Journal of Virological Methods. 155:44-54

PVS-RIPO is a recombinant oncolytic poliovirus designed for clinical application to target CD155 expressing malignant gliomas and other malignant diseases. PVS-RIPO does not replicate in healthy neurons and is therefore non-pathogenic in rodent and n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d381eaa715f2697d3d24afa23a85bd20
https://doi.org/10.1016/j.jviromet.2008.09.020

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Growth factor-independent proliferation of erythroid cells infected with Friend spleen focus-forming virus is protein kinase C dependent but does not require Ras-GTP

Autor: Charlotte Hanson, Sandra K. Ruscetti, Delores Thompson, Rebecca Lyons, Karen W. Muszynski, Angelo Spadaccini

Publikováno v: Journal of virology. 74(18)

Interaction of erythropoietin (Epo) with its cell surface receptor activates signal transduction pathways which result in the proliferation and differentiation of erythroid cells. Infection of erythroid cells with the Friend spleen focus-forming viru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa83e0e2449964b0c5b68a3c5e50eda
https://pubmed.ncbi.nlm.nih.gov/10954544

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Both the Polycythemia- and Anemia-Inducing Strains of Friend Spleen Focus-Forming Virus Induce Constitutive Activation of the Raf-1/Mitogen-Activated Protein Kinase Signal Transduction Pathway

Autor: Takashi Ohashi, Charlotte Hanson, Sandra K. Ruscetti, Karen W. Muszynski

The erythroleukemia-inducing Friend spleen focus-forming virus (SFFV) encodes a unique envelope glycoprotein which allows erythroid cells to proliferate and differentiate in the absence of erythropoietin (Epo). In an attempt to understand how the vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfb3a799d17316bf2be883c7dc9ad88
https://europepmc.org/articles/PMC124561/

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Raf-1 protein is required for growth factor-induced proliferation of primitive hematopoietic progenitors stimulated with synergistic combinations of cytokines

Autor: John Gooya, Francis W. Ruscetti, Karen W. Muszynski, Jonathan R. Keller, Diana Linnekin

Publikováno v: Stem cells (Dayton, Ohio). 15(1)

Raf-1 is a serine/threonine kinase that has been identified as a component of growth factor-activated signal transduction pathways, and is required for growth factor-induced proliferation of leukemic cell lines and colony formation of hematopoietic p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac107c06fdc4866e6395cffcf73991b
https://pubmed.ncbi.nlm.nih.gov/9007224

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