Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Karen W. Dodson"'
Autor:
Taylor M. Nye, Zongsen Zou, Chloe L. P. Obernuefemann, Jerome S. Pinkner, Erin Lowry, Kent Kleinschmidt, Karla Bergeron, Aleksandra Klim, Karen W. Dodson, Ana L. Flores-Mireles, Jennifer N. Walker, Daniel Garrett Wong, Alana Desai, Michael G. Caparon, Scott J. Hultgren
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Catheter-associated urinary tract infections (CAUTIs), a common cause of healthcare-associated infections, are caused by a diverse array of pathogens that are increasingly becoming antibiotic resistant. We analyze the microbial occurrences i
Externí odkaz:
https://doaj.org/article/bbcf2d87b3694f7e89d8818948dfec1e
Autor:
Timothy J. Straub, Wen-Chi Chou, Abigail L. Manson, Henry L. Schreiber, Bruce J. Walker, Christopher A. Desjardins, Sinéad B. Chapman, Kerrie L. Kaspar, Orsalem J. Kahsai, Elizabeth Traylor, Karen W. Dodson, Meredith A. J. Hullar, Scott J. Hultgren, Christina Khoo, Ashlee M. Earl
Publikováno v:
BMC Microbiology, Vol 21, Iss 1, Pp 1-17 (2021)
Abstract Background Urinary tract infections (UTIs) affect 15 million women each year in the United States, with > 20% experiencing frequent recurrent UTIs. A recent placebo-controlled clinical trial found a 39% reduction in UTI symptoms among recurr
Externí odkaz:
https://doaj.org/article/5c7c3468a1dc4d208ef6d1c73577946d
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
Externí odkaz:
https://doaj.org/article/3a5f29334ea64e1f9ee71e0a3f5098e7
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Urinary tract infections (UTIs) are predominantly caused by uropathogenic Escherichia coli (UPEC). UPEC pathogenesis requires passage through a severe population bottleneck involving intracellular bacterial communities (IBCs) that are clonal
Externí odkaz:
https://doaj.org/article/23fc2786fb1345899573ba2c852d6774
Autor:
Alexandra E. Paharik, Henry L. Schreiber, Caitlin N. Spaulding, Karen W. Dodson, Scott J. Hultgren
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-4 (2017)
Editorial summary Antibiotics have become the standard of care for bacterial infections. However, rising rates of antibiotic-resistant infections are outpacing the development of new antimicrobials. Broad-spectrum antibiotics also harm beneficial mic
Externí odkaz:
https://doaj.org/article/f84b021d73e44538a9cc72a810556195
Autor:
Matt S. Conover, Maria Hadjifrangiskou, Joseph J. Palermo, Michael E. Hibbing, Karen W. Dodson, Scott J. Hultgren
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT Uropathogenic Escherichia coli (UPEC) is the primary etiological agent of over 85% of community-acquired urinary tract infections (UTIs). Mouse models of infection have shown that UPEC can invade bladder epithelial cells in a type 1 pilus-de
Externí odkaz:
https://doaj.org/article/f6b8f3861da246f0b41276a74d832bad
Autor:
Sarah E. Greene, Jerome S. Pinkner, Erik Chorell, Karen W. Dodson, Carrie L. Shaffer, Matt S. Conover, Jonathan Livny, Maria Hadjifrangiskou, Fredrik Almqvist, Scott J. Hultgren
Publikováno v:
mBio, Vol 5, Iss 6 (2014)
ABSTRACT Chaperone-usher pathway (CUP) pili are extracellular organelles produced by Gram-negative bacteria that mediate bacterial pathogenesis. Small-molecule inhibitors of CUP pili, termed pilicides, were rationally designed and shown to inhibit ty
Externí odkaz:
https://doaj.org/article/4870dddc644f4c4fb9421e07a3921141
Autor:
Chia Hung, Yizhou Zhou, Jerome S. Pinkner, Karen W. Dodson, Jan R. Crowley, John Heuser, Matthew R. Chapman, Maria Hadjifrangiskou, Jeffrey P. Henderson, Scott J. Hultgren
Publikováno v:
mBio, Vol 4, Iss 5 (2013)
ABSTRACT Bacterial biofilms are ubiquitous in nature, and their resilience is derived in part from a complex extracellular matrix that can be tailored to meet environmental demands. Although common developmental stages leading to biofilm formation ha
Externí odkaz:
https://doaj.org/article/5a4bcd5b79014d9682f23bd1cacb04a0
Autor:
Colin J. Worby, Henry L. Schreiber, Timothy J. Straub, Lucas R. van Dijk, Ryan A. Bronson, Benjamin S. Olson, Jerome S. Pinkner, Chloe L. P. Obernuefemann, Vanessa L. Muñoz, Alexandra E. Paharik, Philippe N. Azimzadeh, Bruce J. Walker, Christopher A. Desjardins, Wen-Chi Chou, Karla Bergeron, Sinéad B. Chapman, Aleksandra Klim, Abigail L. Manson, Thomas J. Hannan, Thomas M. Hooton, Andrew L. Kau, H. Henry Lai, Karen W. Dodson, Scott J. Hultgren, Ashlee M. Earl
Publikováno v:
Nature Microbiology. 7:630-639
Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of infection being a significant risk factor. While the gut is a known reservoir for uropathogenic bacteria, the role of the microbiota in rUTI remains uncle
Autor:
Kevin O. Tamadonfar, Gisela Di Venanzio, Jerome S. Pinkner, Karen W. Dodson, Vasilios Kalas, Maxwell I. Zimmerman, Jesus Bazan Villicana, Gregory R. Bowman, Mario F. Feldman, Scott J. Hultgren
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Multidrug-resistant Acinetobacter baumannii infections are an urgent clinical problem and can cause difficult-to-treat nosocomial infections. During such infections, like catheter-associated urinary tract infections (CAUTI), A. baumannii rely on adhe