Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Karen Vervisch"'
Autor:
Clarissa Van Hecke, Wim Trypsteen, Eva Malatinkova, Ward De Spiegelaere, Karen Vervisch, Sofie Rutsaert, Sabine Kinloch-de Loes, Magdalena Sips, Linos Vandekerckhove
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 443-454 (2019)
Background: A wide range of host restriction factors (RF) become upregulated upon HIV-1 infection to suppress viral infectivity and may aid viremic control in vivo. This cross-sectional study evaluated HIV-1 RFs and dependency factors in HIV infected
Externí odkaz:
https://doaj.org/article/1136f58e76a74e148cdf17df17ae635c
Autor:
Eva Malatinkova, Ward De Spiegelaere, Pawel Bonczkowski, Maja Kiselinova, Karen Vervisch, Wim Trypsteen, Margaret Johnson, Chris Verhofstede, Danny de Looze, Charles Murray, Sabine Kinloch-de Loes, Linos Vandekerckhove
Publikováno v:
eLife, Vol 4 (2015)
Persistent reservoirs remain the major obstacles to achieve an HIV-1 cure. Prolonged early antiretroviral therapy (ART) may reduce the extent of reservoirs and allow for virological control after ART discontinuation. We compared HIV-1 reservoirs in a
Externí odkaz:
https://doaj.org/article/36943e574147408383d7ca3d3e4e7a23
Autor:
Ward De Spiegelaere, Jan Philippé, Karen Vervisch, Chris Verhofstede, Eva Malatinkova, Maja Kiselinova, Wim Trypsteen, Pawel Bonczkowski, Dirk Vogelaers, Steven Callens, Jean Ruelle, Kabamba Kabeya, Stephane De Wit, Petra Van Acker, Vicky Van Sandt, Marie-Paule Emonds, Paul Coucke, Erica Sermijn, Linos Vandekerckhove
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123525 (2015)
Abacavir is a nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral therapy in HIV-1-infected patients. Because this drug can cause a hypersensitivity reaction that is correlated with the presence of the HLA-B*57:01 al
Externí odkaz:
https://doaj.org/article/e34e992d508a4e7ca2e338a8729d4f0b
Autor:
Peter Messiaen, Ward De Spiegelaere, Jose Alcami, Karen Vervisch, Petra Van Acker, Bruno Verhasselt, Pieter Meuwissen, Esther Calonge, Nuria Gonzalez, Felix Gutierrez-Rodero, Carmen Rodriguez-Martín, Erica Sermijn, Bruce Poppe, Dirk Vogelaers, Chris Verhofstede, Linos Vandekerckhove
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50204 (2012)
BACKGROUND: As Lens epithelium-derived growth factor (LEDGF/p75) is an important co-factor involved in HIV-1 integration, the LEDGF/p75-IN interaction is a promising target for the new class of allosteric HIV integrase inhibitors (LEDGINs). Few data
Externí odkaz:
https://doaj.org/article/0a04cb81e9814c7f8af7587c9364fd46
Autor:
Sofie Rutsaert, Ward De Spiegelaere, Karen Vervisch, Linos Vandekerckhove, Sabine Kinloch-de Loes, Magdalena Sips, Wim Trypsteen, Clarissa Van Hecke, Eva Malatinkova
Publikováno v:
EBIOMEDICINE
EBioMedicine
EBioMedicine
Background: A wide range of host restriction factors (RF) become upregulated upon HIV-1 infection to suppress viral infectivity and may aid viremic control in vivo. This cross-sectional study evaluated HIV-1 RFs and dependency factors in HIV infected
Autor:
Wim Trypsteen, Karen Vervisch, Sofie Rutsaert, Linos Vandekerckhove, Marie-Angélique De Scheerder, Ward De Spiegelaere, Clarissa Van Hecke, Maja Kiselinova
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
SCIENTIFIC REPORTS
Scientific Reports
SCIENTIFIC REPORTS
Scientific Reports
HIV-1 DNA quantification serves as an important reservoir biomarker in HIV cure trials. However, the high genetic diversity of HIV-1 represented by different subtypes may bring inaccuracy in quantifying HIV-1 DNA and a sensitive and validated assay c
Autor:
Ward De Spiegelaere, Jan De Neve, Eva Malatinkova, Olivier Thas, Wim Trypsteen, Maja Kiselinova, Linos Vandekerckhove, Matthijs Vynck, Karen Vervisch, Pawel Bonczkowski
Publikováno v:
Analytical and Bioanalytical Chemistry. 407:5827-5834
Digital PCR is rapidly gaining interest in the field of molecular biology for absolute quantification of nucleic acids. However, the first generation of platforms still needs careful validation and requires a specific methodology for data analysis to
Autor:
Karen Vervisch, Chris Verhofstede, Margaret A. Johnson, C. Van Hecke, L. Vandekerckhove, W. De Spiegelaere, Magdalena Sips, Wim Trypsteen, Eva Malatinkova, S. Kinloch-de Loës
Publikováno v:
Journal of Virus Eradication, Vol 3, Iss, Pp 2-(2017)
Autor:
Sofie Rutsaert, Eric Florence, Guido Vanham, L. Vandekerckhove, Elisabeth Willems, Pieter Pannus, Karen Vervisch, M. Van Frankenhuijsen, P. Adams, W. Despiegelaere, Maja Kiselinova, C. Devaux, L. Heyndrickx
Publikováno v:
Journal of Virus Eradication, Vol 3, Iss, Pp 3-(2017)
Autor:
Eva Malatinkova, Karen Vervisch, Pawel Bonczkowski, Bruno Verhasselt, Wim Trypsteen, Jolien Vermeire, Maja Kiselinova, Peter Messiaen, Ward De Spiegelaere, Linos Vandekerckhove
Publikováno v:
Journal of Clinical Microbiology. 53:699-701
Episomal HIV-1 two-long terminal repeat (2-LTR) circles are considered markers for ongoing viral replication. Two sample processing procedures were compared to accurately quantify 2-LTR in patients by using droplet digital PCR (ddPCR). Here, we show