Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379

Autor: Pierre Jean-Marie Bernard Raboisson, Jan Martin Berke, Wendy Mostmans, Karen Vergauwen, Pascale Dehertogh, Frederik Pauwels, Koen Vandyck

Publikováno v: Antimicrob Agents Chemother

Capsid assembly is a critical step in the hepatitis B virus (HBV) life cycle, mediated by the core protein. Core is a potential target for new antiviral therapies, the capsid assembly modulators (CAMs). JNJ-56136379 (JNJ-6379) is a novel and potent C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8f00d6e3cb5fb6cf750c0e63d0e117
https://doi.org/10.1128/aac.02439-19

Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV)

Autor: Ann Vos, Karen Vergauwen, Geert Rombouts, Fuliang Hou, Jan-Martin Berke, Pierre Raboisson, Bing Huang, Bart Stoops, Wim Gaston Verschueren, Koen Vandyck, Jingmei Yang, Pascale Dehertogh, Abdellah Tahri, Yiming Wu

Publikováno v: Journal of medicinal chemistry. 61(14)

Small molecule induced hepatitis B virus (HBV) capsid assembly modulation is considered an attractive approach for new antiviral therapies against HBV. Here we describe efforts toward the discovery of a HBV capsid assembly modulator in a hit-to-lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bfe5dc13f1db313dd8c3c84a323815
https://pubmed.ncbi.nlm.nih.gov/29906396

Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary Human Hepatocytes Infected with Hepatitis B Virus

Autor: Koen Vandyck, Jan Martin Berke, Pascale Dehertogh, Karen Vergauwen, Frederik Pauwels, Wendy Mostmans, Ellen Van Damme

Publikováno v: Antimicrobial Agents and Chemotherapy. 61

Hepatitis B virus (HBV) capsid assembly is a critical step in the propagation of the virus and is mediated by the core protein. Due to its multiple functions in the viral life cycle, core became an attractive target for new antiviral therapies. Capsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116addcf62a8870a0961c2c862e57a72
https://doi.org/10.1128/aac.00560-17

Novel antibiotics targeting respiratory ATP synthesis in gram-positive pathogenic bacteria

Autor: David Francis Alain Lançois, Ovidiu Pop, Kristien Bonroy, Nacer Lounis, W Balemans, Dirk Bald, Koen Andries, Anil Koul, Jerome Guillemont, Ron Gilissen, Karen Vergauwen, Miguel F.C. De Bolle, Luc Vranckx, Magali Madeleine Simone Motte, Selena Mol, Holger Lill

Publikováno v: Antimicrobial agents and chemotherapy

Emergence of drug-resistant bacteria represents a high, unmet medical need, and discovery of new antibacterials acting on new bacterial targets is strongly needed. ATP synthase has been validated as an antibacterial target in Mycobacterium tuberculos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef92af00614cdfb92a9d36da12a2ad2
https://hdl.handle.net/10067/1025780151162165141

Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis

Autor: Hinrich W. H. Göhlmann, Rudy Edmond Willebrords, Karen Vergauwen, Anil Koul, Luc Vranckx, Alain Philippe Poncelet, Jerome Guillemont, Dirk Bald, Najoua Dendouga, W Balemans, Koen Andries, Ilse Van den Wyngaert

Publikováno v: Journal of Biological Chemistry, 283, 25273-25280. American Society for Biochemistry and Molecular Biology Inc.
Journal of biological chemistry
Koul, A, Vranckx, L, Dendouga, N, Balemans, W, van den Wyngaert, I, Vergauwen, K, Goehlmann, H W H, Willebrords, R, Poncelet, A, Guillemont, J, Bald, D & Andries, K 2008, ' Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis. ', Journal of Biological Chemistry, vol. 283, pp. 25273-25280 . https://doi.org/10.1074/jbc.M803899200

An estimated one-third of the world population is latently infected with Mycobacterium tuberculosis. These nonreplicating, dormant bacilli are tolerant to conventional anti-tuberculosis drugs, such as isoniazid. We recently identified diarylquinoline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6352cd59fe77333b378282647447db8d
https://research.vu.nl/en/publications/5ffab6a5-9a3e-45c4-ad3c-e7cc363c36f7