Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Karen Townson"'
Autor:
Peter Lin, Gary G. Chicchi, Julie A. DeMartino, Neil Collinson, Marc M. Kurtz, Susan Boyce, Robert J. DeVita, Alan Wheeldon, Jonathan R. Young, Stephen Moore, Emma J. Carlson, Kwei-Lan C. Tsao, Sander G. Mills, Karen Townson, George A. Doss, Gregori J. Morriello, Nadia M.J. Rupniak
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:2156-2170
Previous work on human NK(1) antagonists in which the core of the structure is a substituted pyrrolidine has been disclosed. These compounds showed good binding affinity and functional IP activity, however, many did not exhibit the necessary brain pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07bdec5af551942f4ff8d7149d7c129
https://doi.org/10.1016/j.bmc.2007.11.081
https://doi.org/10.1016/j.bmc.2007.11.081
Autor:
Nicholas M. Grundy, Christopher John Andrews, Ian Jepson, Jane Karen Townson, Mark Skipsey, Robert Edwards, Ian Cummins
Publikováno v:
Pesticide Biochemistry and Physiology. 82:205-219
Glutathione transferases in soybean ( Gm GSTs) involved in herbicide detoxification in cell suspension cultures were purified by S -hexylglutathione affinity chromatography and resolved by a combination of HPLC and SDS–PAGE into 11 polypeptides. An
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18aa34efcf53133e1240a1b361c96993
https://doi.org/10.1016/j.pestbp.2004.11.009
https://doi.org/10.1016/j.pestbp.2004.11.009
Autor:
David W Bartlett, Jane Karen Townson, Glynn Mitchell, Tim R. Hawkes, David C Holt, Rex A Wichert, Torquil Eoghan Macleod Fraser
Publikováno v:
Pest Management Science. 57:120-128
Mesotrione is a new herbicide being developed for the selective pre- and post-emergence control of a wide range of broad-leaved and grass weeds in maize (Zea mays). It is a member of the benzoylcyclohexane-1,3-dione family of herbicides, which are ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d348e562d3a00644190c2295d087ab34
https://doi.org/10.1002/1526-4998(200102)57:2<120::aid-ps254>3.0.co
https://doi.org/10.1002/1526-4998(200102)57:2<120::aid-ps254>3.0.co
Publikováno v:
Archives of Biochemistry and Biophysics. 374:261-268
Glyoxalase I and glutathione transferase (GST) are two glutathione-dependent enzymes which are enhanced in plants during cell division and in response to diverse stress treatments. In soybean, a further connection between these two enzymes has been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbed4ecc68af6239f087d9239c4cc840
https://doi.org/10.1006/abbi.1999.1596
https://doi.org/10.1006/abbi.1999.1596
Autor:
David W. Langton, Youlin Wang, Katherine M. Rogers, Glynn Mitchell, Lucretia S. Edwards, Kate R. Sharples, Mike P. Langford, Jane Karen Townson, Tim R. Hawkes
Publikováno v:
Pesticide Science. 54:368-376
5-tert-Butyl-carbamoyloxy-3-(3-trifluoromethyl) phenyl-4-thiazolidinone (compound 1), a representative of a novel class of thiazolidinone herbicides, shows potential for the pre-emergence control of grasses and small-seeded broad-leaved weeds in crop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28acf23ee3af893b6efdd983995f5b8f
https://doi.org/10.1002/(sici)1096-9063(199812)54:4<368::aid-ps845>3.0.co
https://doi.org/10.1002/(sici)1096-9063(199812)54:4<368::aid-ps845>3.0.co
Autor:
Carol Morris, Christopher John Andrews, Ian Jepson, Mark Skipsey, Robert Edwards, Jane Karen Townson
Publikováno v:
Pesticide Science. 51:213-222
Using extracts from suspension-cultured cells of soybean (Glycine max cv. Mandarin) as a source of active enzymes, the activities of glutathione transferases (GSTs) catalysing the conjugation of 1-chloro-2,4-dinitrobenzene (CDNB) and selective herbic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::063e29e15bc220ad7a66b78ff2b2b897
https://doi.org/10.1002/(sici)1096-9063(199710)51:2<213::aid-ps622>3.0.co
https://doi.org/10.1002/(sici)1096-9063(199710)51:2<213::aid-ps622>3.0.co
Autor:
Laurence Dube, Richard Friesen, Karen Townson, Daniel Dube, Jean-François Lévesque, Susana Liu, Michel Gallant, Dwight Macdonald, Donald W. Nicholson, Zheng Huang, Renee Aspiotis, Rebecca Dias, Sebastien Laliberte, Patrick Lacombe, Pierre Hamel, Daniel Guay, Kerry A. Waters, Mario Girard, Joseph A. Mancini, Stephen Day, Robert N. Young, Angela Styhler, Yves Girard
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
The structure-activity relationship of a novel series of 8-biarylnaphthyridinones acting as type 4 phosphodiesterase (PDE4) inhibitors for the treatment of long-term memory loss and mild cognitive impairment is described herein. The manuscript descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2255fde5f2d2efbe35673f8b5806fa8e
https://pubmed.ncbi.nlm.nih.gov/20933411
https://pubmed.ncbi.nlm.nih.gov/20933411
Autor:
Susan Boyce, Kwei-Lan Tsao, Gary G. Chicchi, Karen Townson, Sander G. Mills, Julie A. DeMartino, Neil Collinson, Marc M. Kurtz, Gregori J. Morriello, Robert J. DeVita, Alan Wheeldon, Nadia M.J. Rupniak, Emma J. Carlson, Tricia Johnson, Xinchun Tong, Song Zheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(19)
Previously, we had disclosed a novel class of hNK(1) antagonists based on the 5,5-fused pyrrolidine core. These compounds displayed subnanomolar hNK(1) affinity along with good efficacy in a gerbil foot-tapping (GFT) model, but unfortunately they had
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8e996df1a1b78f6c5cafc9b1d3ed98
https://pubmed.ncbi.nlm.nih.gov/20729082
https://pubmed.ncbi.nlm.nih.gov/20729082
Autor:
Karen Townson, Gregori J. Morriello, Kwei-Lan Tsao, Gary G. Chicchi, Nadia M.J. Rupniak, Sander G. Mills, Mikhail Reibarkh, Philip Davies, Julie A. DeMartino, Neil Collinson, Alan Wheeldon, Marc M. Kurtz, Stephen Moore, Tricia Johnson, F.D. Tattersall, Susan Boyce, Robert J. DeVita, Emma J. Carlson, Song Zheng, Xinchun Tong
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(6)
Previous work on human NK(1) (hNK(1)) antagonists in which the core of the structure is a 5,5-fused pyrrolizinone has been disclosed. The structural-activity-relationship studies on simple alpha- and beta-substituted compounds of this series provided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5f1466795a40ae5e39fb30c2992976
https://pubmed.ncbi.nlm.nih.gov/20153964
https://pubmed.ncbi.nlm.nih.gov/20153964
Autor:
Lorraine Punter, Karen Townson, Alastair Morrison, Judith Latcham, Evelyn Grau, Sophie Bourdu, Alan Wheeldon, Wendy J. Winchester, Anna K. Bassil, Noureddine Zebda, Emma M. Jarvie, Angela M. Grimes, George P. Livi, Alejandro Abuin, Gary B.T. Moore, David P. Hurp, Kelly M. Downham, Gareth J. Sanger
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 296(4)
P2Y receptors have been reported to modulate gastrointestinal functions. The newest family member is the nucleotide-sugar receptor P2Y14. P2ry14 mRNA was detected throughout the rat gut, with the highest level being in the forestomach. We investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6644bc0c52bfe7433b51c0704993db
https://pubmed.ncbi.nlm.nih.gov/19164486
https://pubmed.ncbi.nlm.nih.gov/19164486