Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Karen Thudium"'
Autor:
Lisa Davis, Nathan Riccitelli, Nancy Valencia, Irene L. Ch’en, Shabnam Tangri, Jennifer L. Brogdon, Creton Kalfoglou, Karen Thudium Mueller, Reinhold Pollner
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 535-541 (2021)
Chimeric antigen receptor (CAR)-T cell therapies reprogram T cells to engage and eliminate cancer cells. Patients’ T cells are transduced in vitro using lentiviral or retroviral vectors containing a CAR transgene. Following infusion, CAR-T cells ex
Externí odkaz:
https://doaj.org/article/2b681f0aeb284e3f903d79b38dc6b465
Autor:
Andrew M. Stein, Stephan A. Grupp, John E. Levine, Theodore W. Laetsch, Michael A. Pulsipher, Michael W. Boyer, Keith J. August, Bruce L. Levine, Lori Tomassian, Sweta Shah, Mimi Leung, Pai‐Hsi Huang, Rakesh Awasthi, Karen Thudium Mueller, Patricia A. Wood, Carl H. June
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 5, Pp 285-295 (2019)
Tisagenlecleucel is a chimeric antigen receptor–T cell therapy that facilitates the killing of CD19+ B cells. A model was developed for the kinetics of tisagenlecleucel and the impact of therapies for treating cytokine release syndrome (tocilizumab
Externí odkaz:
https://doaj.org/article/e1eac9e64fa4445bbb240eabb2a86beb
Autor:
Awasthi, Rakesh *, Pacaud, Lida, Waldron, Edward, Tam, Constantine S., Jäger, Ulrich, Borchmann, Peter, Jaglowski, Samantha, Foley, Stephen Ronan, van Besien, Koen, Wagner-Johnston, Nina D., Kersten, Marie José, Schuster, Stephen J., Salles, Gilles, Maziarz, Richard T., Anak, Özlem, del Corral, Christopher, Chu, Jufen, Gershgorin, Irina, Pruteanu-Malinici, Iulian, Chakraborty, Abhijit, Mueller, Karen Thudium, Waller, Edmund K.
Publikováno v:
In Blood Advances 11 February 2020 4(3):560-572
Autor:
Mueller, Karen Thudium, Maude, Shannon L., Porter, David L., Frey, Noelle, Wood, Patricia, Han, Xia, Waldron, Edward, Chakraborty, Abhijit, Awasthi, Rakesh, Levine, Bruce L., Melenhorst, J. Joseph, Grupp, Stephan A., June, Carl H., Lacey, Simon F.
Publikováno v:
In Blood 23 November 2017 130(21):2317-2325
Autor:
Stephan A. Grupp, Gabor Kari, Harald J. Maier, Karen Thudium Mueller, Edward R. Waldron, Kevin Nguyen, Creton Kalfoglou, Heather E. Stefanski, Jochen Buechner, Andre Baruchel, Peter Bader, G. Doug Myers, Tim Driscoll, Gregory A. Yanik, Hidefumi Hiramatsu, Michael W. Boyer, Susana Rives, Muna Qayed, Theodore W. Laetsch, Shannon L. Maude, Xia Han, Michael A. Pulsipher
Supplementary Data from Next-Generation Sequencing of Minimal Residual Disease for Predicting Relapse after Tisagenlecleucel in Children and Young Adults with Acute Lymphoblastic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f640dfe63ee4f38cc502810e22e2845
https://doi.org/10.1158/2643-3230.22544129
https://doi.org/10.1158/2643-3230.22544129
Autor:
Stephan A. Grupp, Gabor Kari, Harald J. Maier, Karen Thudium Mueller, Edward R. Waldron, Kevin Nguyen, Creton Kalfoglou, Heather E. Stefanski, Jochen Buechner, Andre Baruchel, Peter Bader, G. Doug Myers, Tim Driscoll, Gregory A. Yanik, Hidefumi Hiramatsu, Michael W. Boyer, Susana Rives, Muna Qayed, Theodore W. Laetsch, Shannon L. Maude, Xia Han, Michael A. Pulsipher
We assessed minimal residual disease (MRD) detection and B-cell aplasia after tisagenlecleucel therapy for acute lymphoblastic leukemia (ALL) to define biomarkers predictive of relapse (N = 143). Next-generation sequencing (NGS) MRD detection >0 in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a79c0ec9a1437e58820595e137dfe73
https://doi.org/10.1158/2643-3230.c.6550538.v1
https://doi.org/10.1158/2643-3230.c.6550538.v1
Autor:
Marco Ruella, Saar Gill, Carl H. June, Stephan A. Grupp, Shannon L. Maude, Noelle V. Frey, Matthew D. Weitzman, Ophir Shalem, Shelley L. Berger, Charly R. Good, Karen Thudium Mueller, Elena J. Orlando, Shunichiro Kuramitsu, Sangya Agarwal, Raymone Pajarillo, Xueqing Maggie Lu, Seok Jae Hong, Katharina E. Hayer, Pranali Ravikumar, Olga Shestova, Yong Gu Lee, Nathan Singh
RNA and ATACseq data of CART19 cells exposed to BIDko Nalm6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421f4615aeb33c0484de809891ea10ae
https://doi.org/10.1158/2159-8290.22535477.v1
https://doi.org/10.1158/2159-8290.22535477.v1
Autor:
Marco Ruella, Saar Gill, Carl H. June, Stephan A. Grupp, Shannon L. Maude, Noelle V. Frey, Matthew D. Weitzman, Ophir Shalem, Shelley L. Berger, Charly R. Good, Karen Thudium Mueller, Elena J. Orlando, Shunichiro Kuramitsu, Sangya Agarwal, Raymone Pajarillo, Xueqing Maggie Lu, Seok Jae Hong, Katharina E. Hayer, Pranali Ravikumar, Olga Shestova, Yong Gu Lee, Nathan Singh
Exposure to death receptor impaired tumor cells results in progressive CART19 dysfunction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44de6a4ab2c710d3d4442f09dfb713c9
https://doi.org/10.1158/2159-8290.22535501.v1
https://doi.org/10.1158/2159-8290.22535501.v1
Autor:
Marco Ruella, Saar Gill, Carl H. June, Stephan A. Grupp, Shannon L. Maude, Noelle V. Frey, Matthew D. Weitzman, Ophir Shalem, Shelley L. Berger, Charly R. Good, Karen Thudium Mueller, Elena J. Orlando, Shunichiro Kuramitsu, Sangya Agarwal, Raymone Pajarillo, Xueqing Maggie Lu, Seok Jae Hong, Katharina E. Hayer, Pranali Ravikumar, Olga Shestova, Yong Gu Lee, Nathan Singh
Primary resistance to CD19-directed chimeric antigen receptor T-cell therapy (CART19) occurs in 10% to 20% of patients with acute lymphoblastic leukemia (ALL); however, the mechanisms of this resistance remain elusive. Using a genome-wide loss-of-fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecf6af83736892bbacd5098c738d5df9
https://doi.org/10.1158/2159-8290.c.6547871.v1
https://doi.org/10.1158/2159-8290.c.6547871.v1
Autor:
Shannon L. Maude, Patricia A. Wood, Tetiana Taran, Mimi Leung, Sweta S. Shah, Lori Tomassian, Carl H. June, Bruce L. Levine, Abhijit Chakraborty, Denise Sickert, Andrew M. Stein, Rakesh Awasthi, Jason Hamilton, Keith J. August, Michael W. Boyer, Michael A. Pulsipher, Theodore W. Laetsch, John E. Levine, Stephan A. Grupp, Edward Waldron, Karen Thudium Mueller
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d26112761ad0dea9547df85ecdd32fd
https://doi.org/10.1158/1078-0432.22468554.v1
https://doi.org/10.1158/1078-0432.22468554.v1