Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Karen Smith Korsholm"'
Autor:
Kidola Jeremiah, Eric Lyimo, Christian Ritz, George PrayGod, Kathryn Tucker Rutkowski, Karen Smith Korsholm, Morten Ruhwald, Dereck Tait, Harleen M S Grewal, Daniel Faurholt-Jepsen
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252808 (2021)
BackgroundThe prevalence of latent tuberculosis infection (LTBI) is vastly higher than that of tuberculosis (TB) disease and this enormous reservoir of individuals with LTBI impacts the global TB control strategy. Adolescents are at greatest risk of
Externí odkaz:
https://doaj.org/article/2c5ad83ca4084d5da8326d60ff5fbefb
Autor:
Signe Tandrup Schmidt, Gabriel Kristian Pedersen, Malene Aaby Neustrup, Karen Smith Korsholm, Thomas Rades, Peter Andersen, Camilla Foged, Dennis Christensen
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
There is an unmet medical need for new subunit vaccines that induce cytotoxic T-lymphocyte (CTL) responses to prevent infection with a number of pathogens. However, stimulation of CTL responses via clinically acceptable subcutaneous (s.c.) and intram
Externí odkaz:
https://doaj.org/article/8427bedde79244b9bf42c3d36b602a87
Autor:
Sara Ram Pedersen, Jan Pravsgaard Christensen, Søren Buus, Michael Rasmussen, Karen Smith Korsholm, Morten Nielsen, Mogens Helweg Claesson
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145629 (2016)
The aim of the present study was to identify influenza A-derived peptides which bind to both HLA class I and -II molecules and by immunization lead to both HLA class I and class II restricted immune responses. Eight influenza A-derived 9-11mer peptid
Externí odkaz:
https://doaj.org/article/a3f575c9eb6b4fbdb293449a66de0575
Publikováno v:
Pharmaceutics, Vol 8, Iss 1, p 7 (2016)
The development of subunit vaccines has become very attractive in recent years due to their superior safety profiles as compared to traditional vaccines based on live attenuated or whole inactivated pathogens, and there is an unmet medical need for i
Externí odkaz:
https://doaj.org/article/07d0b12da1694ae8ac1f3ce0d84b07f1
Autor:
Camilla Line Olsen, Signe Tandrup Schmidt, Karen Smith Korsholm, Peter Andersen, Henrik Franzyk, Thomas Rades, Katharina Wørzner, Dennis Christensen, Camilla Foged
Publikováno v:
Tandrup Schmidt, S, Line Olsen, C, Franzyk, H, Wørzner, K, Smith Korsholm, K, Rades, T, Andersen, P, Foged, C & Christensen, D 2019, ' Comparison of two different PEGylation strategies for the liposomal adjuvant CAF09 : Towards induction of CTL responses upon subcutaneous vaccine administration ', European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, vol. 140, pp. 29-39 . https://doi.org/10.1016/j.ejpb.2019.04.020
Using subunit vaccines, e.g., based on peptide or protein antigens, to teach the immune system to kill abnormal host cells via induction of cytotoxic T lymphocytes (CTL) is a promising strategy against intracellular infections and cancer. However, cu
Autor:
Morten Ruhwald, George PrayGod, Kidola Jeremiah, Dereck Tait, Harleen M. S. Grewal, Karen Smith Korsholm, Daniel Faurholt-Jepsen, Kathryn Tucker Rutkowski, Christian Ritz, Eric Lyimo
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252808 (2021)
PLoS ONE
e0252808
PLOS ONE
Jeremiah, K, Lyimo, E, Ritz, C, PrayGod, G, Rutkowski, K T, Korsholm, K S, Ruhwald, M, Tait, D, Grewal, H M S & Faurholt-Jepsen, D 2021, ' Prevalence of Mycobacterium tuberculosis infection as measured by the QuantiFERON-TB Gold assay and ESAT-6 free IGRA among adolescents in Mwanza, Tanzania ', P L o S One, vol. 16, no. 6, e0252808 . https://doi.org/10.1371/journal.pone.0252808
PLoS ONE
e0252808
PLOS ONE
Jeremiah, K, Lyimo, E, Ritz, C, PrayGod, G, Rutkowski, K T, Korsholm, K S, Ruhwald, M, Tait, D, Grewal, H M S & Faurholt-Jepsen, D 2021, ' Prevalence of Mycobacterium tuberculosis infection as measured by the QuantiFERON-TB Gold assay and ESAT-6 free IGRA among adolescents in Mwanza, Tanzania ', P L o S One, vol. 16, no. 6, e0252808 . https://doi.org/10.1371/journal.pone.0252808
BackgroundThe prevalence of latent tuberculosis infection (LTBI) is vastly higher than that of tuberculosis (TB) disease and this enormous reservoir of individuals with LTBI impacts the global TB control strategy. Adolescents are at greatest risk of
Autor:
Mikkel Lohmann Schiøth, Fabrice Rose, Anan Yaghmur, Sarah Justesen, Cecilie Maria Madsen, Karen Smith Korsholm, Henrik Franzyk, Camilla Foged, Birte Martin-Bertelsen, Rie Selchau Kallerup, Dennis Christensen
Publikováno v:
Molecular Pharmaceutics. 14:2294-2306
Synthetic mycobacterial cord factor analogues, e.g., trehalose 6,6'-dibehenate (TDB), are highly promising adjuvants due to their strong immunopotentiating capabilities, but their biophysical properties have remained poorly characterized. Here, we re
Autor:
Karen Smith Korsholm, Malene Aaby Neustrup, Camilla Foged, Thomas Rades, Signe Tandrup Schmidt, Dennis Christensen, Peter Andersen, Stine Harloff-Helleberg
Publikováno v:
Pharmaceutical Research. 34:1716-1727
Induction of cell-mediated immune (CMI) responses is crucial for vaccine-mediated protection against difficult vaccine targets, e.g., Chlamydia trachomatis (Ct). Adjuvants are included in subunit vaccines to potentiate immune responses, but many mark
Autor:
Peter Bang, Sara Knudsen, Tom Cole, Anja Weinreich Olsen, Morten Ruhwald, Helene B Juel, Peter Andersen, Robin J. Shattock, Karen Smith Korsholm, L. R. McFarlane, Frank Follmann, David A. Lewis, Hannah Cheeseman, Ingrid Kromann, Sonya Abraham, Kjersti Moen, Suzanne Day, Max Kristiansen, Rebecca B Dohn
Publikováno v:
The Lancet. Infectious diseases. 19(10)
Summary Background Chlamydia is the most common sexually transmitted bacterial infection worldwide. National screening programmes and antibiotic treatment have failed to decrease incidence, and to date no vaccines against genital chlamydia have been
Autor:
Bernd Lepenies, Camilla Foged, Dennis Christensen, Henrik Franzyk, Alexandra Huber, Karen Smith Korsholm, Rie Selchau Kallerup, Roland Lang
Publikováno v:
Innate Immunity
The T-cell adjuvanticity of mycobacterial cord factor trehalose 6,6'-dimycolate (TDM) is well established. The identification of the C-type lectin Mincle on innate immune cells as the receptor for TDM and its synthetic analogue trehalose 6,6'-dibehen