Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Karen Smith Blesch"'
Autor:
Ronald Gieschke, Karen Smith Blesch, Bruno Reigner, Yuko Tsukamoto, Jean-Louis Steimer, Hans Ulrich Burger
Publikováno v:
Investigational New Drugs. 21:195-223
Preclinical studies, along with Phase I, II, and III clinical trials demonstrate the pharmacokinetics, pharmacodynamics, safety and efficacy of a new drug under well controlled circumstances in relatively homogeneous populations. However, these types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71214a7a1b8b062750df710a166e62c3
https://doi.org/10.1023/a:1023525513696
https://doi.org/10.1023/a:1023525513696
Publikováno v:
British Journal of Clinical Pharmacology. 55:252-263
Aims To assess the relationship between systemic exposure to capecitabine metabolites and parameters of efficacy and safety in patients with advanced or metastatic colorectal cancer from two phase III studies. Methods Concentration–effect analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54af1a631223ba05eb76afff316296f3
https://doi.org/10.1046/j.1365-2125.2003.01765.x
https://doi.org/10.1046/j.1365-2125.2003.01765.x
Autor:
Bruno Reigner, Karen Smith Blesch
Publikováno v:
European Journal of Clinical Pharmacology. 57:835-845
Background: Selection of the starting dose for the entry into humans (EIH) study is an essential first step in clinical drug development. Objectives: This paper is a review of different approaches that may be used to calculate the starting dose, pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009cfc767ac98dabe0ba5f7cdf9a794c
https://doi.org/10.1007/s00228-001-0405-6
https://doi.org/10.1007/s00228-001-0405-6
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 29:25-47
Capecitabine has been developed as an orally administered tumor selective fluoropyrimidine for use in the treatment of breast and colorectal cancer. The metabolic pathway for capecitabine includes 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c15209a66afabfa4c2baf45503ca0f16
https://doi.org/10.1023/a:1015716617967
https://doi.org/10.1023/a:1015716617967
Autor:
Karen Smith Blesch
Publikováno v:
Encyclopedia of Biostatistics
Stage migration due to different methods of cancer staging can artifactually inflate cancer survival rates by shifting patients with a marginal prognosis out of a better prognosis group into a worse prognosis group. This bias can be avoided by ensuri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dae6a453014125308ea1803be959b0e
https://doi.org/10.1002/9781118445112.stat05306
https://doi.org/10.1002/9781118445112.stat05306
Publikováno v:
Clinical Pharmacokinetics. 40:85-104
Capecitabine is a novel oral fluoropyrimidine carbamate that is preferentially converted to the cytotoxic moiety fluorouracil (5-fluorouracil; 5-FU) in target tumour tissue through a series of 3 metabolic steps. After oral administration of 1250 mg/m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f74c41a7e6fdecf87d95923704f9a41
https://doi.org/10.2165/00003088-200140020-00002
https://doi.org/10.2165/00003088-200140020-00002
Autor:
Karen Smith Blesch
Publikováno v:
Seminars in Oncology Nursing. 12:219-225
Objectives: To provide a framework for considering home nursing care of the cancer patient within the context of cancer rehabilitation and to briefly review various aspects of cancer rehabilitation. Data sources: Review articles and reference books o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585e58d571da8eb7ea34c5de16495dde
https://doi.org/10.1016/s0749-2081(96)80039-8
https://doi.org/10.1016/s0749-2081(96)80039-8
Autor:
Karen Smith Blesch, Thomas R. Prohaska
Publikováno v:
Cancer Nursing. 14:141-147
Although some controversy exists, the Papanicolaou (Pap) smear for cervical cancer screening is widely accepted as an effective mechanism for cancer control. An issue of interest to clinicians and behavioral scientists is the underrepresentation of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2537472c1c3622e50039927cbbbe3599
https://doi.org/10.1097/00002820-199106000-00005
https://doi.org/10.1097/00002820-199106000-00005
Publikováno v:
Journal of the American Dietetic Association. 99:1275-1277
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0494b818a5f8730a26ef2903b96765ed
https://doi.org/10.1016/s0002-8223(99)00313-2
https://doi.org/10.1016/s0002-8223(99)00313-2
Publikováno v:
Journal of clinical epidemiology. 49(8)
Age comparisons of survival in cancer cohorts generally utilize relative survival rates, which are based on indicators of the probability of survival for a given number of years after diagnosis. Cancer relative survival rates for the same number of y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bc1b027dc428e3e54b8134eb9f0600
https://pubmed.ncbi.nlm.nih.gov/8699207
https://pubmed.ncbi.nlm.nih.gov/8699207