Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Karen Sliedregt-Bol"'
Autor:
Haixiang Yu, Karen Sliedregt-Bol, Theo J.C. Van Berkel, Erik A.L. Biessen, Gijs A. van der Marel, Herman S. Overkleeft
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 26:1531-1537
Objective— The calcineurin/nuclear factor of activated T cells (NFAT) axis plays a pivotal role in the regulation of critical genes in vascular smooth muscle cell (vSMC) proliferation and inflammation, which makes NFAT inhibition an attractive moda
Autor:
Theo J.C. Van Berkel, Karen Sliedregt-Bol, Sabine M.W. van Rossenberg, Perry Prince, Erik A.L. Biessen, Jacques H. van Boom, Gijs A. van der Marel
Publikováno v:
Bioconjugate Chemistry. 14:1077-1082
Peptide nucleic acids (PNA's) have shown to hold potential as antisense drugs. In this study we have designed PNA drugs for the microsomal triglyceride transfer protein (MTP), which is known to play a critical role in the assembly of atherogenic lipo
Autor:
Jacques H. van Boom, Theo J.C. Van Berkel, Karen Sliedregt-Bol, Sabine M.W. van Rossenberg, Gerben Koning, Gijs A. van der Marel, Hans van den Elst, Erik A.L. Biessen
Publikováno v:
ChemBioChem. 4:633-639
Colchicine, an established tubulin inhibitor, interferes with the trafficking of endocytotic vesicles and thereby promotes the escape of lysosome-entrapped compounds. To improve its potency and cell specificity, a targeted prodrug of colchicine was s
Autor:
Karen Sliedregt-Bol, Cees van Kooten, Erik A.L. Biessen, Andrea M. Woltman, Herman S. Overkleeft, Sjef Verbeek, Ilze Bot, Peter Boross, Filip M. Segers, Theo J.C. Van Berkel, Gijs A. van der Marel, Haixiang Yu
Publikováno v:
Faseb Journal, 27(10), 4136-4146. FASEB
FASEB Journal, 27(10), 4136-4146
FASEB Journal, 27(10), 4136-4146
The CD40/CD40L dyad is deemed to play a central role in several inflammatory processes, including atherosclerosis. As CD40 is overexpressed in atherosclerotic lesions, it constitutes a promising candidate for targeted imaging approaches. Here we desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e14bed4917a731ce981a663085196c7
https://hdl.handle.net/1887/99885
https://hdl.handle.net/1887/99885
Publikováno v:
Bioorganic & Medicinal Chemistry. 7:1043-1047
Replacement of amide bonds in peptides by sulfonamide moieties resulted in peptidosulfonamides with an increased stability towards protease catalyzed degradation. In addition to protection of the protease cleavage site, it was found that introduction
Autor:
Bernard Meunier, Isabelle Roland, Karen Sliedregt-Bol, Marguerite Pitié, Robert Kiss, Christophe Boldron, Jan Reedijk, Paul de Hoog, Patrick Gamez
Publikováno v:
Journal of medicinal chemistry. 50(13)
The design and synthesis of new heterodinuclear DNA-targeting agents are described. The abilities of cisplatin and Cu(3-Clip-Phen) [Cu(1-(1,10-phenanthrolin-3-yloxy)-3-(1,10-phenanthrolin-8-yloxy)propan-2-amine)Cl2], an artificial DNA-cleaving agent,
Autor:
Theo J.C. Van Berkel, Erik A.L. Biessen, Hans M.G. Princen, Peter A C 't Hoen, Jacques H. van Boom, Perry Prince, Martin K. Bijsterbosch, Erica Van der Bilt, A. Rob P. M. Valentijn, Karen Sliedregt-Bol, Nico J. Meeuwenoord, Gijs A. van der Marel
Publikováno v:
Bioconjugate chemistry. 13(2)
In this study, we present the design and synthesis of an antisense peptide nucleic acid (asPNA) prodrug, which displays an improved biodistribution profile and an equally improved capacity to reduce the levels of target mRNA. The prodrug, K(GalNAc)(2
Autor:
Erik A.L. Biessen, Karen Sliedregt-Bol, Theo J.C. Van Berkel, Jacques H. van Boom, Nico J. Meeuwenoord, Gijs A. van der Marel, Sabine M.W. van Rossenberg
Publikováno v:
Journal of Biological Chemistry, 277(48), 45803-45810
The transfection ability of nonviral gene therapy vehicles is generally hampered by untimely lysosomal degradation of internalized DNA. In this study we describe the development of a targeted lysosome disruptive element to facilitate the escape of DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06023892fc07ed9986e5f1d736b3642e
https://hdl.handle.net/1887/50012
https://hdl.handle.net/1887/50012
Autor:
Paul de Hoog, Christophe Boldron, Patrick Gamez, Karen Sliedregt-Bol, Isabelle Roland, Marguerite Pitié, Robert Kiss, Bernard Meunier, Jan Reedijk
Publikováno v:
Journal of Medicinal Chemistry; Jun2007, Vol. 50 Issue 13, p3148-3152, 5p