Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Karen Silence"'
Autor:
Jamie L. Lim, Roy Augustinus, Jaap J. Plomp, Kasra Roya-Kouchaki, Dana L. E. Vergoossen, Yvonne Fillié-Grijpma, Josephine Struijk, Rachel Thomas, Daniela Salvatori, Christophe Steyaert, Christophe Blanchetot, Roeland Vanhauwaert, Karen Silence, Silvère M. van der Maarel, Jan J. Verschuuren, Maartje G. Huijbers
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Muscle-specific kinase (MuSK) is crucial for acetylcholine receptor (AChR) clustering and thereby neuromuscular junction (NMJ) function. NMJ dysfunction is a hallmark of several neuromuscular diseases, including MuSK myasthenia gravis. Aimin
Externí odkaz:
https://doaj.org/article/773f61341607498fb5e4068db23c08e5
Autor:
Els Beirnaert, Aline Desmyter, Silvia Spinelli, Marc Lauwereys, Lucien Aarden, Torsten Dreier, Remy Loris, Karen Silence, Caroline Pollet, Christian Cambillau, Hans de Haard
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The activity of tumor necrosis factor (TNF), a cytokine involved in inflammatory pathologies, can be inhibited by antibodies or trap molecules. Herein, llama-derived variable heavy-chain domains of heavy-chain antibody (VHH, also called Nanobodies™
Externí odkaz:
https://doaj.org/article/1c64a6d754764252ae11961ca4838dd0
Autor:
Ahmad Awada, Nicolas Leupin, Alain Thibault, Marc Peeters, Vincent Ribrag, Hans de Haard, Domenica Gandini, Anna Hultberg, Karen Silence, Jean-Marie Michot, Luc Van Rompaey, Torsten Dreier, Mahan Moshir, Jean-Charles Soria, Marie Maerevoet, Dominique Bron, Fritz Offner, Sylvie Rottey, Christian Rolfo, Philippe Aftimos
Purpose: The purpose of this study was to evaluate safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor efficacy of ARGX-110, a glyco-engineered monoclonal antibody, targeting CD70, in patients with CD70 expressing advanced malignanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f67c8aed5e69084842277494b50f36b
https://doi.org/10.1158/1078-0432.c.6527006.v1
https://doi.org/10.1158/1078-0432.c.6527006.v1
Autor:
Ahmad Awada, Nicolas Leupin, Alain Thibault, Marc Peeters, Vincent Ribrag, Hans de Haard, Domenica Gandini, Anna Hultberg, Karen Silence, Jean-Marie Michot, Luc Van Rompaey, Torsten Dreier, Mahan Moshir, Jean-Charles Soria, Marie Maerevoet, Dominique Bron, Fritz Offner, Sylvie Rottey, Christian Rolfo, Philippe Aftimos
More details about inclusion and exclusion criteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4ba8d81175c304fee0f68912d285fb
https://doi.org/10.1158/1078-0432.22468604
https://doi.org/10.1158/1078-0432.22468604
Autor:
Paolo Michieli, Hans de Haard, Torsten Dreier, Alain Thibault, Michael Saunders, Peter Brouckaert, Flavio Maina, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Fabienne Lamballe, Benjamin Roux, Raimond Heukers, Els Festjens, Karen Silence, Gitte De Boeck, Valérie Hanssens, Christophe Blanchetot, Natalie De Jonge, Leander Huyghe, Virginia Morello, Anna Hultberg
Hepatocyte growth factor (HGF) and its receptor MET represent validated targets for cancer therapy. However, HGF/MET inhibitors being explored as cancer therapeutics exhibit cytostatic activity rather than cytotoxic activity, which would be more desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72807272b6bf8be1075b6f07eeff9a65
https://doi.org/10.1158/0008-5472.c.6507042.v1
https://doi.org/10.1158/0008-5472.c.6507042.v1
Autor:
Paolo Michieli, Hans de Haard, Torsten Dreier, Alain Thibault, Michael Saunders, Peter Brouckaert, Flavio Maina, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Fabienne Lamballe, Benjamin Roux, Raimond Heukers, Els Festjens, Karen Silence, Gitte De Boeck, Valérie Hanssens, Christophe Blanchetot, Natalie De Jonge, Leander Huyghe, Virginia Morello, Anna Hultberg
Supplementary Tables S1-S7. Binding of WT52, WT52-E and WT52-D to human and mouse Fc gamma receptors (S1); ADCC activity of engineered antibodies (S2); In vitro characterization of the germlined G52 antibody (S3); Binding of G52 and ARGX-111 to human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd857487f04091ada111625ba04fad4
https://doi.org/10.1158/0008-5472.22406316
https://doi.org/10.1158/0008-5472.22406316
Autor:
Paolo Michieli, Hans de Haard, Torsten Dreier, Alain Thibault, Michael Saunders, Peter Brouckaert, Flavio Maina, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Fabienne Lamballe, Benjamin Roux, Raimond Heukers, Els Festjens, Karen Silence, Gitte De Boeck, Valérie Hanssens, Christophe Blanchetot, Natalie De Jonge, Leander Huyghe, Virginia Morello, Anna Hultberg
Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6565d44a59a176be702ec7d00f10864f
https://doi.org/10.1158/0008-5472.22406319.v1
https://doi.org/10.1158/0008-5472.22406319.v1
Autor:
Paolo Michieli, Hans de Haard, Torsten Dreier, Alain Thibault, Michael Saunders, Peter Brouckaert, Flavio Maina, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Fabienne Lamballe, Benjamin Roux, Raimond Heukers, Els Festjens, Karen Silence, Gitte De Boeck, Valérie Hanssens, Christophe Blanchetot, Natalie De Jonge, Leander Huyghe, Virginia Morello, Anna Hultberg
Supplementary Figures S1-S7. WT52 inhibits both HGF-dependent and -independent MET autophosphorylation (S1); MET-targeted ADCC prevents tumor recurrence and suppresses metastatic dissemination in an adjuvant orthotopic model of mammary carcinoma (S2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18e075a4cdf87c1e3380cb4bd731bf0
https://doi.org/10.1158/0008-5472.22406322.v1
https://doi.org/10.1158/0008-5472.22406322.v1
Autor:
Karen Silence, Lauri M Bloemenkamp, Liesbeth Van de Ven, Jeroen W. Bos, Elisabeth de Zeeuw, Leonard H. van den Berg, R. Jeroen Pasterkamp, Kevin Budding, Hans de Haard, Peter Boross, Kim Dijkxhoorn, C. Erik Hack, Marc D. Jansen, Jeanette H. W. Leusen, W. Ludo van der Pol, Chantall A.D. Curial, Lill Eva Johansen, Inge Van de Walle, Christophe Blanchetot
Publikováno v:
Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3
article-version (Version of Record) 3
Background and ObjectivesTo determine the role of complement in the disease pathology of multifocal motor neuropathy (MMN), we investigated complement activation, and inhibition, on binding of MMN patient-derived immunoglobulin M (IgM) antibodies in
Autor:
Luc van Rompaey, Marc Peeters, Marie Maerevoet, Jean-Charles Soria, Philippe Aftimos, D. Bron, Ahmad Awada, Nicolas Leupin, Christian Rolfo, Anna Hultberg, Fritz Offner, Karen Silence, Hans de Haard, Domenica Gandini, Vincent Ribrag, Sylvie Rottey, Alain Thibault, Mahan Moshir, Torsten Dreier, Jean-Marie Michot
Publikováno v:
Clinical cancer research
Purpose: The purpose of this study was to evaluate safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor efficacy of ARGX-110, a glyco-engineered monoclonal antibody, targeting CD70, in patients with CD70 expressing advanced malignanc