Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Karen S. L. Lam"'
Autor:
Kang Chen, Lai Yee Cheong, Yuan Gao, Yaming Zhang, Tianshi Feng, Qin Wang, Leigang Jin, Eric Honoré, Karen S. L. Lam, Weiping Wang, Xiaoyan Hui, Aimin Xu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Although thyroid hormone (TH) has anti-obesity potential, systemic administration of TH causes severe adverse effects without obvious weight loss. Here, the authors show that adipose tissue-targeted delivery of TH with liposomes is a safe and efficie
Externí odkaz:
https://doaj.org/article/a41188231e854b5bb69ffa79bdacf04d
Autor:
Junda Zhong, Chloe Y. Y. Cheung, Xiuli Su, Chi-Ho Lee, Yi Ru, Carol H. Y. Fong, Yan Liu, Cynthia K. Y. Cheung, Karen S. L. Lam, Zongwei Cai, Aimin Xu
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-11 (2022)
Abstract Background Bioactive lipids play an important role in insulin secretion and sensitivity, contributing to the pathophysiology of type 2 diabetes (T2D). This study aimed to identify novel lipid species associated with incident T2D in a nested
Externí odkaz:
https://doaj.org/article/af1a99a33d8b46bbba278f5016c07fe9
Autor:
Leiluo Geng, Cheuk-Lik Wong, Boya Liao, Ying Lin, Hao Han, Karen S. L. Lam, Aimin Xu, Chi-Ho Lee, Vicki H. K. Tam
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Differential diagnosis of hypoglycaemia can at times be challenging for patients who appear to be well. Here we identify the case of a 66-year-old Chinese man presenting with recurrent episodes of fasting hypoglycaemia and confusion without any other
Externí odkaz:
https://doaj.org/article/ffc33648ef704d2ba17b74937c82a2b7
Autor:
Yuen-Kwun Wong, Chloe Y. Y. Cheung, Clara S. Tang, JoJo S. H. Hai, Chi-Ho Lee, Kui-Kai Lau, Ka-Wing Au, Bernard M. Y. Cheung, Pak-Chung Sham, Aimin Xu, Karen S. L. Lam, Hung-Fat Tse
Publikováno v:
Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-12 (2019)
Abstract Background High-sensitivity troponin I (hs-Tnl) and B-type natriuretic peptide (BNP) are promising prognostic markers for coronary artery disease (CAD). This prospective cohort study investigated whether a combination of these cardiac biomar
Externí odkaz:
https://doaj.org/article/fc6a8049ae44438aabf29871c72e76ba
Autor:
Xiaoping Wu, Lingling Shu, Zixuan Zhang, Jingjing Li, Jiuyu Zong, Lai Yee Cheong, Dewei Ye, Karen S. L. Lam, Erfei Song, Cunchuan Wang, Aimin Xu, Ruby L. C. Hoo
Publikováno v:
Advanced Science, Vol 8, Iss 11, Pp n/a-n/a (2021)
Abstract Development of liver fibrosis results in drastic changes in the liver microenvironment, which in turn accelerates disease progression. Although the pathological function of various hepatic cells in fibrogenesis is identified, the crosstalk b
Externí odkaz:
https://doaj.org/article/904c7664e6f44a7a9a751237616b77b9
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
It has been increasingly recognized that inflammation plays an important role in the pathogenesis of cardiovascular disease (CVD). In obesity, adipose tissue inflammation, especially in the visceral fat depots, contributes to systemic inflammation an
Externí odkaz:
https://doaj.org/article/89b5bd0887964cddba79a3e70ba2fc51
Autor:
Kelvin H. M. Kwok, Karen S. L. Lam
Publikováno v:
Endocrinology and Metabolism, Vol 32, Iss 2, Pp 145-151 (2017)
Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family. Acting in an endocrine fashion, it increases glucose uptake, modulates lipid metabolism, and sensitizes insulin response in metabolically active organs, including the liver
Externí odkaz:
https://doaj.org/article/ede7eeed0ac74c329dcacb6e1120c866
Autor:
Xiaomu Li, Kenneth K. Y. Cheng, Zhuohao Liu, Jin-Kui Yang, Baile Wang, Xue Jiang, Yawen Zhou, Philip Hallenborg, Ruby L. C. Hoo, Karen S. L. Lam, Yasuhiro Ikeda, Xin Gao, Aimin Xu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruva
Externí odkaz:
https://doaj.org/article/433046fc179446af96ac4977f8bb7b86
Autor:
Chi-Ho Lee, Ruth S. M. Chan, Helen Y. L. Wan, Yu-Cho Woo, Chloe Y. Y. Cheung, Carol H. Y. Fong, Bernard M. Y. Cheung, Tai-Hing Lam, Edward Janus, Jean Woo, Karen S. L. Lam
Publikováno v:
Nutrients, Vol 10, Iss 11, p 1664 (2018)
Background: Conflicting and population-dependent findings have been reported from epidemiological studies on the associations of dietary intake of anti-oxidant vitamins with cardiovascular events. We investigated the prospective relationship between
Externí odkaz:
https://doaj.org/article/ddfae628ddc145278178c126110f3ba2
Autor:
Janice B. B. Lam, Kim H. M. Chow, Aimin Xu, Karen S. L. Lam, Jing Liu, Nai-Sum Wong, Randall T. Moon, Peter R. Shepherd, Garth J. S. Cooper, Yu Wang
Publikováno v:
PLoS ONE, Vol 4, Iss 4 (2009)
Externí odkaz:
https://doaj.org/article/953f7a94adb44ed38347efdaa3fd1ad8