Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Karen S. Haggard"'
AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey
Autor:
Raymond E. Conrow, Mark R. Hellberg, David Earnest, Gary W. Williams, Pete Delgado, W. Dennis Dean, Najam A. Sharif, Peter G. Klimko, Michael S. Gaines, Karen S. Haggard, Robert D. Selliah, Marsha A. McLaughlin, Daniel Scott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4525-4528
A series of 11-oxa prostaglandin analogs was evaluated for FP receptor binding and activation. Several compounds having aryloxy-terminated lower chains were found to be potent agonists. Topical ocular dosing of AL-12182, the isopropyl ester prodrug o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eaa7f878c1b411bce26660af3350532
https://doi.org/10.1016/j.bmcl.2004.06.037
https://doi.org/10.1016/j.bmcl.2004.06.037
Autor:
Mark R. Hellberg, Karen S. Haggard, Gary W. Williams, John B. Liao, Peter G. Klimko, Marsha A. McLaughlin, Bryon S. Severns, Najam A. Sharif
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:3451-3469
A novel series of 15-fluoro prostaglandins with phenoxy termination of the omega-chain was synthesized and evaluated for binding and functional activation of the prostaglandin FP receptor in vitro and for side effect potential and topical ocular hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3f4077fe51bf4946881e500b817cc4
https://doi.org/10.1016/j.bmc.2004.04.034
https://doi.org/10.1016/j.bmc.2004.04.034
Autor:
Thomas R. Dean, Gustav Graff, Mark R. Hellberg, Tai-Lee Ke, Peter G. Klimko, Karen S. Haggard
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 19:97-103
Bimatoprost (Lumigan), the ethyl amide derivative of the potent prostaglandin FP agonist 17-phenyl-trinor PGF(2alpha), has been reported to be a member of a pharmacologically unique class of ocular hypotensive agents. To confirm that bimatoprost, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a7e914b5976b441ce74f6459db603a
https://doi.org/10.1089/108076803321637627
https://doi.org/10.1089/108076803321637627
Autor:
Jesse A. May, Ernest U. Do, Robert Selliah, Judith Egan, Anura P. Dantanarayana, Karen S. Haggard
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 44:173-183
A method for the preparation of tritium labeled travoprost, a new ocular hypotensive prostaglandin, is described. A highly selective catalytic deiodination has been identified which provides [phenyl-2-3H]-travoprost in a single synthetic step from 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5c5f30f659d3ea74e897ed207f4fa17
https://doi.org/10.1002/jlcr.441
https://doi.org/10.1002/jlcr.441
Autor:
Jon C. Nixon, Karen S. Haggard, Mark R. Hellberg, Abdelmoula Namil, Karen C. David, Pete Delgado, Gustav Graff, Timothy L. Kessler
Publikováno v:
ChemInform. 30
A series of phenolic antioxidant ester and amide derivatives of the nonsteroidal antiinflammatory drug naproxen was designed to have both antiinflammatory and cytoprotective activity. Compounds were evaluated in vitro both for antioxidant activity, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::896420cf05a48201ba3d5727affc6abb
https://doi.org/10.1002/chin.199922138
https://doi.org/10.1002/chin.199922138
Autor:
Karen C. David, Timothy L. Kessler, Mark R. Hellberg, Abdelmoula Namil, Jon C. Nixon, Pete Delgado, Gustav Graff, Karen S. Haggard
Publikováno v:
Journal of medicinal chemistry. 42(2)
A series of phenolic antioxidant ester and amide derivatives of the nonsteroidal antiinflammatory drug naproxen was designed to have both antiinflammatory and cytoprotective activity. Compounds were evaluated in vitro both for antioxidant activity, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7237ab014784d9e5efa654f077299410
https://pubmed.ncbi.nlm.nih.gov/9925732
https://pubmed.ncbi.nlm.nih.gov/9925732