Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Karen S. Gilbert"'
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 31:630-646
Thiarabine is undergoing clinical trials. In support of that effort combination therapy of thiarabine plus six clinical anticancer agents was evaluated using various human tumor xenograft models. The antitumor activity of thiarabine in combination ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a01dc1d578a0cc99cab6ace6bcb802
https://doi.org/10.1080/15257770.2012.712181
https://doi.org/10.1080/15257770.2012.712181
Publikováno v:
Cancer Chemotherapy and Pharmacology. 68:399-403
4′-Thio-β-D-arabinofuranosylcytosine (4′-thio-ara-C), which has shown a broad spectrum of antitumor activity against human tumor systems in mice and is undergoing clinical trials, was evaluated for cross-resistance to seven clinical agents in or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6632f4608bee2da2983b3e0ac5b8b501
https://doi.org/10.1007/s00280-010-1498-3
https://doi.org/10.1007/s00280-010-1498-3
Publikováno v:
Cancer Chemotherapy and Pharmacology. 51:422-426
4'-Thio-beta -d-arabinofuranosylcytosine (4'-thio-ara-C), which has shown significant cytotoxicity against a panel of human tumor lines, was evaluated for antitumor activity against a spectrum of human tumor systems in mice.Antitumor activity was eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5773bb80bfc8d48b8aac1f25246ed2
https://doi.org/10.1007/s00280-003-0589-9
https://doi.org/10.1007/s00280-003-0589-9
Autor:
Eric J. Sorscher, William B. Parker, William R. Waud, Scott A. King, Alan Wells, John A. Montgomery, G. Yancey Gillespie, Paula W. Allan, Karen S. Gilbert, John A. Secrist, L. Lee Bennett
Publikováno v:
Human Gene Therapy. 8:1637-1644
We have developed a new strategy for the gene therapy of cancer based on the activation of purine nucleoside analogs by transduced E. coli purine nucleoside phosphorylase (PNP, E.C. 2.4.2.1). The approach is designed to generate antimetabolites intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b074c52b7bc8f7f9b7a0f9ff98db0200
https://doi.org/10.1089/hum.1997.8.14-1637
https://doi.org/10.1089/hum.1997.8.14-1637
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 31(9)
Thiarabine was evaluated for antitumor activity in seven human leukemia, lymphoma, and myeloma xenograft models to explore the activity in hematological malignancies. Thiarabine was active against all of the human leukemia and lymphoma lines tested,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09680f05d5d6f2c7064c2ada631c3334
https://pubmed.ncbi.nlm.nih.gov/23004929
https://pubmed.ncbi.nlm.nih.gov/23004929
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 31(1)
A murine P388 leukemia line fully resistant to thiarabine was obtained after five courses of intraperitoneal treatment (daily for nine consecutive days). The subline was sensitive as was the parental P388/0 line to 5-fluorouracil, gemcitabine, cyclop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893f71ef61528f920deffa40951695d7
https://pubmed.ncbi.nlm.nih.gov/22257207
https://pubmed.ncbi.nlm.nih.gov/22257207
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 30(11)
A murine P388 leukemia line fully resistant to thiarabine was obtained after five courses of intraperitoneal treatment (daily for nine consecutive days). The subline was sensitive as was the parental P388/0 line to 5-fluorouracil, gemcitabine, cyclop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207eb9d12125cf287292c71619e655ff
https://pubmed.ncbi.nlm.nih.gov/22060549
https://pubmed.ncbi.nlm.nih.gov/22060549
Autor:
Steven M. Schmid, Anita Tiwari, Joyce E. Harwell, William R. Waud, Robert C. Reynolds, Deborah G. Gordon, Robert F. Struck, Karen S. Gilbert, Beverly D. Garrett
Publikováno v:
ChemInform. 31
Seven new (2-chloroethyl)nitrosocarbamates have been synthesized as potential anticancer alkylating agents. These compounds were designed with carrier moieties that would either act as prodrugs or confer water solubility. All compounds were screened
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c8e6c90422e8245ca8108443788cb7b
https://doi.org/10.1002/chin.200031094
https://doi.org/10.1002/chin.200031094
Publikováno v:
Cancer chemotherapy and pharmacology. 64(2)
Clofarabine increases the activation of 1-beta-D-arabinofuranosyl cytosine (araC) in tumor cells, and combination of these two drugs has been shown to result in good clinical activity against various hematologic malignancies. 1-beta-D-[4-thio-arabino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80768cd61d3362dc59a77f20c398d87e
https://pubmed.ncbi.nlm.nih.gov/19002461
https://pubmed.ncbi.nlm.nih.gov/19002461
Autor:
Yulia Maxuitenko, Patrick Vincent, Xiaomei Zhang, Charles Chen, Karen S. Gilbert, Cheryl Brink, William R. Waud, Christopher A. Carter
Publikováno v:
Cancer chemotherapy and pharmacology. 59(2)
Purpose: Sorafenib tosylate (sorafenib, BAY 43-9006, Nexavar®) is a multi-kinase inhibitor that targets tumor cell proliferation and angiogenesis. These studies evaluated the efficacy and tolerability of combinations of sorafenib plus agents used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69ce8e1a754785b0f9c90cc3dc9d496
https://pubmed.ncbi.nlm.nih.gov/16724239
https://pubmed.ncbi.nlm.nih.gov/16724239