Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Karen S. Curley"'
Autor:
Alison J. Smith, Leslie J. Street, Michael G. N. Russell, George R. Marshall, Robert W. Carling, Ruth M. McKernan, Kevin W. Moore, Andrew Mitchinson, Karen S. Curley, John R. Atack, Robert Narquizian, José L. Castro, Keith A. Wafford, Sally-Anne Thompson, Peter Blurton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:3441-3444
2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones are GABAA receptor benzodiazepine binding site ligands with functional selectivity for the alpha3 subtype over the alpha1 subtype. SAR studies to optimise this functional selectivity are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a0a030d4a5cc3ff2ccefb8cef252a7
https://doi.org/10.1016/j.bmcl.2004.04.085
https://doi.org/10.1016/j.bmcl.2004.04.085
Autor:
Karen S. Curley, Alison N. Hulme
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1083-1091
The syntheses of (2R,3S)-2-tert-butyldiphenylsilyloxymethylpyrrolidin-3-ol (TBDPS-protected CYB-3) (21) and its C(3) epimer (25) have been achieved in 9 and 8 steps respectively from D-serine. However, chiral HPLC analysis of the key β-hydroxy ester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6776dff7912dd2d7915fe42664013a3e
https://doi.org/10.1039/b200415a
https://doi.org/10.1039/b200415a
Autor:
Karen S. Curley, Alison N. Hulme
Publikováno v:
ChemInform. 33
The syntheses of (2R,3S)-2-tert-butyldiphenylsilyloxymethylpyrrolidin-3-ol (TBDPS-protected CYB-3) (21) and its C(3) epimer (25) have been achieved in 9 and 8 steps respectively from D-serine. However, chiral HPLC analysis of the key β-hydroxy ester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e11a8a8acad8f01962fcde7faa74c9c4
https://doi.org/10.1002/chin.200235204
https://doi.org/10.1002/chin.200235204