Výsledky vyhledávání - "Karen S. Charret"

Akademický článek

4-(1H-Pyrazol-1-yl) Benzenesulfonamide Derivatives: Identifying New Active Antileishmanial Structures for Use against a Neglected Disease

Autor: Leonor L. Leon, Veronica F. Amaral, Marilene M. Canto-Cavalheiro, Carlos R. Rodrigues, Júlio C. Borges, Alessandra M. T. Souza, Cesar D. Oliveira, Helena C. Castro, Marie-Luce F. Lira, Tathiane A. Proux, Karen S. Charret, Alice M. R. Bernardino, Roberta K. F. Marra

Publikováno v: Molecules, Vol 17, Iss 11, Pp 12961-12973 (2012)

Leishmaniasis is a neglected disease responsible for about 56,000 deaths every year. Despite its importance, there are no effective, safe and proper treatments for leishmaniasis due to strain resistance and/or drug side-effects. In this work we repor

Externí odkaz: https://doaj.org/article/3c2a97f623aa4174b8ed41bf4a0b8386

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Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents

Autor: Karen S. Charret, Luis M. Ruiz-Pérez, Dolores González-Pacanowska, Antonio E. Vidal, Víctor M. Castillo-Acosta, Cristina E. Requena

Publikováno v: DNA Repair. 11:53-64

DNA repair mechanisms guarantee the maintenance of genome integrity, which is critical for cell viability and proliferation in all organisms. As part of the cellular defenses to DNA damage, apurinic/apyrimidinic (AP) endonucleases repair the abasic s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba67bd0fc35f19bc0610e6727991836
https://doi.org/10.1016/j.dnarep.2011.10.006

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Effect of oral treatment with pyrazole carbohydrazide derivatives against murine infection by Leishmania amazonensis

Autor: Karen S, Charret, Raquel F, Rodrigues, Alice M R, Bernardino, Adriana O, Gomes, Adriana V, Carvalho, Marilene M, Canto-Cavalheiro, Leonor, Leon, Veronica F, Amaral

Publikováno v: The American journal of tropical medicine and hygiene. 80(4)

Newly synthesized pyrazole carbohydrazide derivatives with substituents X = Br/Y = NO(2) and X = NO(2)/Y = Cl were independently investigated in the CBA mouse model of cutaneous leishmaniasis. Animals were infected with Leishmania amazonensis and tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44a877c1077e6d34e4c3515774c65656
https://pubmed.ncbi.nlm.nih.gov/19346377

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