Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Karen S. Britt"'
Autor:
Michael Lahn, Faming Zhang, William T. McMillen, Jeremy R. Graff, Rikke B. Holmgaard, Chandrasekar V. Iyer, Jason Manro, Bryan D. Anderson, Douglas W. Beight, Maria Jose Lallena, Kyla Driscoll, Lei Yan, J. Scott Sawyer, Michael Kalos, Karen S. Britt, David K. Clawson, Philip W. Iversen, Rolf A. Brekken, Karim A. Benhadji, Xiaohong Xu, Durisala Desaiah, Jonathan Michael Yingling, Huocong Huang
Publikováno v:
Oncotarget
Transforming growth factor-β (TGFβ) is an important driver of tumor growth via intrinsic and extrinsic mechanisms, and is therefore an attractive target for developing cancer therapeutics. Using preclinical models, we characterized the anti-tumor a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d8441d71dc2f3af0b1cfba12364fde
https://doi.org/10.18632/oncotarget.23795
https://doi.org/10.18632/oncotarget.23795
Autor:
Karen L. Huss, Charles R. Heap, William T. McMillen, David K. Clawson, Jonathan M. Yingling, J. Scott Sawyer, Robert M. Campbell, Matthew D. Voss, Bryan D. Anderson, Chi Hsin R. King, Elizabeth A. Dierks, Hong Yu Li, Wang Yan, Lei Yan, Sreenivasa Reedy Mundla, Karen S. Britt, Denis J. McCann
Publikováno v:
Journal of Medicinal Chemistry. 51:2302-2306
In our continuing effort to expand the SAR of the quinoline domain of dihydropyrrolopyrazole series, we have discovered compound 15d, which demonstrated the antitumor efficacy with oral bioavailability. This effort also demonstrated that the PK/PD in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74284fcfb2d481b7bc2d3fa3c78f84f8
https://doi.org/10.1021/jm701199p
https://doi.org/10.1021/jm701199p
Autor:
Charles R. Heap, Jill R. Wagner, Lei Yan, Sreenivasa Reedy Mundla, Wang Yan, William T. McMillen, Ku X. Lu, David K. Clawson, Bryan D. Anderson, Chi Hsin R. King, Hong Yu Li, Karen S. Britt, Robert M. Campbell, Jonathan M. Yingling, Matthew Ernst Voss
Publikováno v:
Journal of Medicinal Chemistry. 49:2138-2142
Novel dihydropyrrolopyrazole-substituted benzimidazoles were synthesized and evaluated in vitro as inhibitors of transforming growth factor-beta type I receptor (TGF-beta RI), TGF-beta RII, and mixed lineage kinase-7 (MLK-7). These compounds were fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5274b1d7d4f5ea6265cabe5cd42aed8
https://doi.org/10.1021/jm058209g
https://doi.org/10.1021/jm058209g
Autor:
David Schaer, Chandrasekar V. Iyer, Ivan Inigo, Douglas W. Beight, Stephen Castaneda, Xiaohong Xu, Talbi Kaoudi, Sajan Joseph, Zhao Gaiying, Amy Pappas, Karen S. Britt, Karim A. Benhadji, David Surguladze, Saravanan Parthasarathy, Huaxing Pei, Scott Jason Sawyer, William T. McMillen, Bryan D. Anderson, Huimin Bian, Michael Kalos, Kyla Driscoll
Publikováno v:
Cancer Research. 77:955-955
The transforming growth factor β (TGFβ) signaling pathway is a pleiotropic cellular pathway that plays a critical role in cancer. In fact, aggressive tumors are typically associated with high ligand levels and thus associated with poor prognosis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da73ad2126f7259a3fc50c956783f9bb
https://doi.org/10.1158/1538-7445.am2017-955
https://doi.org/10.1158/1538-7445.am2017-955
Autor:
Stephen Parsons, Lei Yan, Bryan D. Anderson, Karen S. Britt, Edward C. R. Smith, Mort Nicholas A, Hong-Yu Li, Jill R. Wagner, Faming Zhang, J. Scott Sawyer, Theodore Goodson, William Thomas Mcmillen, Beight Douglas W, Jonathan Michael Yingling, David Kent Herron, Robert M. Campbell
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(13)
We have expanded our previously reported series of pyrazole-based inhibitors of the TGF-beta type I receptor kinase domain (TbetaR-I) to now include new 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole analogues. Limited examination of the SAR of this new serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6957b2c2b7d8fe16777b61c299be54b
https://pubmed.ncbi.nlm.nih.gov/15177479
https://pubmed.ncbi.nlm.nih.gov/15177479
Autor:
Hong-yu Li, William T. McMillen, Charles R. Heap, Denis J. McCann, Lei Yan, Robert M. Campbell, Sreenivasa R. Mundla, Chi-Hsin R. King, Elizabeth A. Dierks, Bryan D. Anderson, Karen S. Britt, Karen L. Huss, Matthew D. Voss, Yan Wang, David K. Clawson, Jonathan M. Yingling, J. Scott Sawyer
Publikováno v:
Journal of Medicinal Chemistry; Mar2008, Vol. 51 Issue 7, p2302-2306, 5p