Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Karen S. Aboody"'
Autor:
Tomasz Adamus, Chia-Yang Hung, Chunsong Yu, Elaine Kang, Mohamed Hammad, Linda Flores, Sergey Nechaev, Qifang Zhang, Joanna Marie Gonzaga, Kokilah Muthaiyah, Piotr Swiderski, Karen S. Aboody, Marcin Kortylewski
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 611-620 (2022)
Tropism of neural stem cells (NSCs) to hypoxic tumor areas provides an opportunity for the drug delivery. Here, we demonstrate that NSCs effectively transport antisense oligonucleotides (ASOs) targeting oncogenic and tolerogenic signal transducer and
Externí odkaz:
https://doaj.org/article/2c3ff6cf67da44afa64366d79036cbde
Autor:
Rachael Mooney, Wafa Abidi, Jennifer Batalla-Covello, Hoi Wa Ngai, Caitlyn Hyde, Diana Machado, Asma Abdul-Majid, Yanan Kang, Mohamed Hammad, Linda Flores, Greg Copeland, Thanh Dellinger, Ernest Han, Jacob Berlin, Karen S. Aboody
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2021)
Abstract Background Immortalized, clonal HB1.F3.CD 21 human neural stem/progenitor cells (NSCs), loaded with therapeutic cargo prior to intraperitoneal (IP) injection, have been shown to improve the delivery and efficacy of therapeutic agents in pre-
Externí odkaz:
https://doaj.org/article/00aec8cde6834fa89e6974502295b6ea
Autor:
Leonardo Bianchi, Rachael Mooney, Yvonne R. Cornejo, Emiliano Schena, Jacob M. Berlin, Karen S. Aboody, Paola Saccomandi
Publikováno v:
International Journal of Hyperthermia, Vol 38, Iss 1, Pp 1099-1110 (2021)
Background Photothermal therapy is currently under the spotlight to improve the efficacy of minimally invasive thermal treatment of solid tumors. The interplay of several factors including the radiation wavelengths and the nanoparticle characteristic
Externí odkaz:
https://doaj.org/article/bb7e66e32473434fa1869b31995025c1
Autor:
Mohamed Hammad, Yvonne Cornejo, Linda Flores, Caitlyn Hyde, Hoi Wa Ngai, Min Li, Thanh H. Dellinger, Jianming Lu, Nanhai G. Chen, Rachael Mooney, Karen S. Aboody, Yuman Fong
Publikováno v:
Molecular Therapy: Oncolytics, Vol 19, Iss , Pp 278-282 (2020)
Despite improvements in surgical techniques and chemotherapy, ovarian cancer remains the most lethal gynecologic cancer. Thus, there is an urgent need for more effective therapeutics, particularly for chemo-resistant peritoneal ovarian cancer metasta
Externí odkaz:
https://doaj.org/article/e66a68f7680d47709c841521226bf217
Autor:
Mohamed Hammad, Yvonne R. Cornejo, Jennifer Batalla-Covello, Asma Abdul Majid, Connor Burke, Zheng Liu, Yate-Ching Yuan, Min Li, Thanh H. Dellinger, Jianming Lu, Nanhai G. Chen, Yuman Fong, Karen S. Aboody, Rachael Mooney
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 326-334 (2020)
Oncolytic virotherapy represents a promising approach for treating recurrent and/or drug-resistant ovarian cancer. However, its successful application in the clinic has been hampered by rapid immune-mediated clearance, which reduces viral delivery to
Externí odkaz:
https://doaj.org/article/a51f6d5caa604ac6b003ff4ce600670f
Autor:
Rachael Mooney, Asma Abdul Majid, Jennifer Batalla-Covello, Diana Machado, Xueli Liu, Joanna Gonzaga, Revathiswari Tirughana, Mohamed Hammad, Maciej S. Lesniak, David T. Curiel, Karen S. Aboody
Publikováno v:
Molecular Therapy: Oncolytics, Vol 12, Iss , Pp 79-92 (2019)
Oncolytic virotherapy is a promising approach for treating recurrent and/or drug-resistant ovarian cancer. However, its successful application in the clinic has been hampered by rapid immune-mediated clearance or neutralization of the virus, which re
Externí odkaz:
https://doaj.org/article/640fdbac5c2342d1857ec93f5bfc628b
Autor:
Rachael Mooney, Asma Abdul Majid, Jennifer Batalla-Covello, Diana Machado, Xueli Liu, Joanna Gonzaga, Revathiswari Tirughana, Mohamed Hammad, Thanh H. Dellinger, Maciej S. Lesniak, David T. Curiel, Karen S. Aboody
Publikováno v:
Molecular Therapy: Oncolytics, Vol 17, Iss , Pp 508- (2020)
Externí odkaz:
https://doaj.org/article/808f783cf0f84bda91871996e2c3146f
Autor:
Revathiswari Tirughana, Marianne Z. Metz, Zhongqi Li, Christine Hall, David Hsu, Jim Beltzer, Alexander J. Annala, Diana Oganesyan, Margarita Gutova, Karen S. Aboody
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 48-56 (2018)
Cell-based therapies hold great promise for a myriad of clinical applications. However, as these therapies move from phase I to phase II and III trials, there is a need to improve scale-up of adherent cells for the production of larger good manufactu
Externí odkaz:
https://doaj.org/article/c126929903314962a31a0427d61eb6d7
Autor:
Jennifer Batalla-Covello, Hoi Wa Ngai, Linda Flores, Marisa McDonald, Caitlyn Hyde, Joanna Gonzaga, Mohamed Hammad, Margarita Gutova, Jana Portnow, Tim Synold, David T. Curiel, Maciej S. Lesniak, Karen S. Aboody, Rachael Mooney
Publikováno v:
Cancers, Vol 13, Iss 24, p 6320 (2021)
Tumor tropic neural stem cells (NSCs) can improve the anti-tumor efficacy of oncovirotherapy agents by protecting them from rapid clearance by the immune system and delivering them to multiple distant tumor sites. We recently completed a first-in-hum
Externí odkaz:
https://doaj.org/article/d0ca8a5a6ac94669b6c11f4eb9a8b440
Autor:
Margarita Gutova, Leanne Goldstein, Marianne Metz, Anahit Hovsepyan, Lyudmila G. Tsurkan, Revathiswari Tirughana, Lusine Tsaturyan, Alexander J. Annala, Timothy W. Synold, Zesheng Wan, Robert Seeger, Clarke Anderson, Rex A. Moats, Philip M. Potter, Karen S. Aboody
Publikováno v:
Molecular Therapy: Oncolytics, Vol 4, Iss C, Pp 67-76 (2017)
Despite improved survival for children with newly diagnosed neuroblastoma (NB), recurrent disease is a significant problem, with treatment options limited by anti-tumor efficacy, patient drug tolerance, and cumulative toxicity. We previously demonstr
Externí odkaz:
https://doaj.org/article/5c7db55070fa4313a9cda696861dc9fa