Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Karen Rowland-Yeo"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 11, Pp 1841-1855 (2024)
Abstract In breastfeeding mothers, managing medical conditions presents unique challenges, particularly concerning medication use and breastfeeding practices. The transfer of drugs into breast milk and subsequent exposure to nursing infants raises im
Externí odkaz:
https://doaj.org/article/7a7a850c8fed4fd893be827d3384c2a5
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 11, Pp 1924-1938 (2024)
Abstract Optimal dosing in pregnant and lactating women requires an understanding of the pharmacokinetics in the mother, fetus, and breastfed infant. Physiologically‐based pharmacokinetic (PBPK) modeling can be used to simulate untested scenarios a
Externí odkaz:
https://doaj.org/article/6817e79f49384dab86ed83445977bcd4
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 11, Pp 1830-1834 (2024)
Externí odkaz:
https://doaj.org/article/4717a921d88943d4b41d19b01ec9a036
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 11, Pp 1815-1819 (2024)
Externí odkaz:
https://doaj.org/article/99ba1ba75d6243838475ae3996c203e3
Autor:
Nada Abla, Anne Claire Marrast, Elodie Jambert, Naomi Richardson, Stephan Duparc, Lisa Almond, Karen Rowland Yeo, Xian Pan, Joel Tarning, Ping Zhao, Janice Culpepper, Catriona Waitt, Charlotte Koldeweij, Susan Cole, Andrew S. Butler, Sonia Khier, Jörg J. Möhrle, Myriam El Gaaloul
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Plasmodium vivax malaria remains a global health challenge, with approximately 6.9 million estimated cases in 2022. The parasite has a dormant liver stage, the hypnozoite, which reactivates to cause repeated relapses over weeks, months, or y
Externí odkaz:
https://doaj.org/article/45b60ab3d99845c694b1be738e16f7c1
Autor:
Michael J. Hanley, Karen Rowland Yeo, Meera Tugnait, Shinji Iwasaki, Narayana Narasimhan, Pingkuan Zhang, Karthik Venkatakrishnan, Neeraj Gupta
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 624-637 (2024)
Abstract Brigatinib is an oral anaplastic lymphoma kinase (ALK) inhibitor approved for the treatment of ALK‐positive metastatic non‐small cell lung cancer. In vitro studies indicated that brigatinib is primarily metabolized by CYP2C8 and CYP3A4 a
Externí odkaz:
https://doaj.org/article/f60485c9b0764388b669749419b519e4
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 3, Pp 386-395 (2024)
Abstract Evaluating the safety of primaquine (PQ) during breastfeeding requires an understanding of its pharmacokinetics (PKs) in breast milk and its exposure in the breastfed infant. Physiologically‐based PK (PBPK) modeling is primed to assess the
Externí odkaz:
https://doaj.org/article/aa9102fcfe9a425088a237c1b9f432c6
Autor:
Nolan D Wood, Danelle Smith, Sally A Kinrade, Mark T Sullivan, Craig R Rayner, David Wesche, Kashyap Patel, Karen Rowland-Yeo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 8, p e0012351 (2024)
Moxidectin is approved by the US Food and Drug Administration (US FDA) for the treatment of onchocerciasis (river-blindness) due to Onchocerca volvulus in patients aged 12 years and older. In onchocerciasis-endemic areas, mass drug administration (MD
Externí odkaz:
https://doaj.org/article/9212bc1a647c428a840979071a3a8867
Autor:
Jing Liu, Karen Rowland‐Yeo, Almut Winterstein, Simon Dagenais, Qi Liu, Jeffrey S. Barrett, Rui Zhu, Cyrus Ghobadi, Amita Datta‐Mannan, Joy Hsu, Sujatha Menon, Mariam Ahmed, Pooja Manchandani, Paulien Ravenstijn
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 4, Pp n/a-n/a (2024)
Abstract Real‐world data (RWD) and real‐world evidence (RWE) are now being routinely used in epidemiology, clinical practice, and post‐approval regulatory decisions. Despite the increasing utility of the methodology and new regulatory guideline
Externí odkaz:
https://doaj.org/article/ef7db2fce839459fb90fcc8fc8bede48
Autor:
Nada Abla, Eleanor Howgate, Karen Rowland‐Yeo, Maurice Dickins, Mackenzie C. Bergagnini‐Kolev, Kuan‐Fu Chen, Savannah McFeely, Jennifer J. Bonner, Laura G. A. Santos, Nathalie Gobeau, Howard Burt, Zoe Barter, Hannah M. Jones, David Wesche, Susan A. Charman, Jörg J. Möhrle, Jeremy N. Burrows, Lisa M. Almond
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 9, Pp 1335-1346 (2023)
Abstract As part of a collaboration between Medicines for Malaria Venture (MMV), Certara UK and Monash University, physiologically‐based pharmacokinetic (PBPK) models were developed for 20 antimalarials, using data obtained from standardized in vit
Externí odkaz:
https://doaj.org/article/9ba16da913cf47668851fe83f723f4b5