Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Karen Rowland Yeo"'
Autor:
Michael J. Hanley, Karen Rowland Yeo, Meera Tugnait, Shinji Iwasaki, Narayana Narasimhan, Pingkuan Zhang, Karthik Venkatakrishnan, Neeraj Gupta
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 624-637 (2024)
Abstract Brigatinib is an oral anaplastic lymphoma kinase (ALK) inhibitor approved for the treatment of ALK‐positive metastatic non‐small cell lung cancer. In vitro studies indicated that brigatinib is primarily metabolized by CYP2C8 and CYP3A4 a
Externí odkaz:
https://doaj.org/article/f60485c9b0764388b669749419b519e4
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 3, Pp 386-395 (2024)
Abstract Evaluating the safety of primaquine (PQ) during breastfeeding requires an understanding of its pharmacokinetics (PKs) in breast milk and its exposure in the breastfed infant. Physiologically‐based PK (PBPK) modeling is primed to assess the
Externí odkaz:
https://doaj.org/article/aa9102fcfe9a425088a237c1b9f432c6
Autor:
Karen Rowland Yeo, David Wesche
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 5, Pp 598-609 (2023)
Abstract Although single‐dose ivermectin has been widely used in mass‐drug administration programs for onchocerciasis and lymphatic filariasis for many years, ivermectin may have utility as an endectocide with mosquito‐lethal effects at dosages
Externí odkaz:
https://doaj.org/article/665f98dc588c423f943dc0e9fa695ceb
Autor:
Peter J. Kilford, Kuan‐Fu Chen, Kim Crewe, Iain Gardner, Oliver Hatley, Alice Ban Ke, Sibylle Neuhoff, Mian Zhang, Karen Rowland Yeo
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 7, Pp 822-832 (2022)
Abstract Physiologically‐based pharmacokinetic (PBPK) modeling is being increasingly used in drug development to avoid unnecessary clinical drug–drug interaction (DDI) studies and inform drug labels. Thus, regulatory agencies are recommending, or
Externí odkaz:
https://doaj.org/article/5516ed2a72b542b39b08ffd22bd4d60c
Autor:
Xian Pan, Karen Rowland Yeo
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 5, Pp 535-539 (2022)
Externí odkaz:
https://doaj.org/article/8ce425637c544a9d8358a2086f0ffa88
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 3, Pp 373-383 (2022)
Abstract There has been a significant increase in the use of physiologically based pharmacokinetic (PBPK) models during the past 20 years, especially for pediatrics. The aim of this study was to give a detailed overview of the growth and areas of app
Externí odkaz:
https://doaj.org/article/6883167fb0144d8eb00309beb24c18c2
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1922 (2023)
Imatinib is mainly metabolised by CYP3A4 and CYP2C8 and is extensively bound to α-acid glycoprotein (AAG). A physiologically based pharmacokinetic (PBPK) model for imatinib describing the CYP3A4-mediated autoinhibition during multiple dosing in gast
Externí odkaz:
https://doaj.org/article/2468fe3045fc4204a335aa9142c80122
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1071-1080 (2021)
Abstract A combination of olanzapine and samidorphan (OLZ/SAM) was recently approved by the US Food and Drug Administration for treatment of patients with schizophrenia or bipolar I disorder. The effects of moderate hepatic impairment on the pharmaco
Externí odkaz:
https://doaj.org/article/85dd3efed4b34c3e9defccc5818900c8
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 967-972 (2021)
Pediatric physiologically‐based pharmacokinetic (PBPK) models have broad application in the drug development process and are being used not only to project doses for clinical trials but increasingly to replace clinical studies. However, the approac
Externí odkaz:
https://doaj.org/article/fcef0e0080e344e9b7c8472297020456
Autor:
Karen Rowland Yeo, Stefanie Hennig, Sriram Krishnaswami, Natasha Strydom, Vivaswath S. Ayyar, Jonathan French, Vikram Sinha, Eric Sobie, Ping Zhao, Lena E. Friberg, France Mentré
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 649-657 (2021)
Externí odkaz:
https://doaj.org/article/0d5d260e746c4c74bf74dee95a357133