Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Karen Rex"'
Autor:
Karen Rex, Shawn Jeffries, Matthew L Brown, Timothy Carlson, Angela Coxon, Flordeliza Fajardo, Brendon Frank, Darin Gustin, Alexander Kamb, Paul D Kassner, Shyun Li, Yihong Li, Kurt Morgenstern, Matthew Plant, Kim Quon, Astrid Ruefli-Brasse, Joanna Schmidt, Elissa Swearingen, Nigel Walker, Zhulun Wang, J E Vivienne Watson, Dineli Wickramasinghe, Mariwil Wong, Guifen Xu, Holger Wesche
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68328 (2013)
Sphingosine kinases (SPHKs) are enzymes that phosphorylate the lipid sphingosine, leading to the formation of sphingosine-1-phosphate (S1P). In addition to the well established role of extracellular S1P as a mitogen and potent chemoattractant, SPHK a
Externí odkaz:
https://doaj.org/article/dfda1f39979a456d9edd17f32579cba1
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
Supplementary methods of tumor xenograft studies and light microscopic evaluation of tumor xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809519f7573d2d85599f5e08e9814dd8
https://doi.org/10.1158/1535-7163.22507701
https://doi.org/10.1158/1535-7163.22507701
Autor:
Roberto Pili, Angela Coxon, Sean Caenepeel, Karen Rex, Sheng-yu Ku, Swathi Ramakrishnan, Eric Ciamporcero, Sreenivasulu Chintala, Kiersten Marie Miles, Li Shen, Remi Adelaiye-Ogala, Nur P. Damayanti, Ashley R. Orillion, May Elbanna
Supplementary Figure S9 shows TIE2 and macrophage markers expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7449173a57b557eaa1044023411f0e
https://doi.org/10.1158/1535-7163.22506595
https://doi.org/10.1158/1535-7163.22506595
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
AMG 337 KINOME scan binding data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ce3cdee7da5472faad9adbf13ac723
https://doi.org/10.1158/1535-7163.22507716
https://doi.org/10.1158/1535-7163.22507716
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
Tumor cell line profiling data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d19fcb3c43643eae23c6970fc140e93
https://doi.org/10.1158/1535-7163.22507713.v1
https://doi.org/10.1158/1535-7163.22507713.v1
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
The MET receptor tyrosine kinase is involved in cell growth, survival, and invasion. Clinical studies with small molecule MET inhibitors have shown the role of biomarkers in identifying patients most likely to benefit from MET-targeted therapy. AMG 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0074a6c1183119f6d623235dd01743f
https://doi.org/10.1158/1535-7163.c.6538764
https://doi.org/10.1158/1535-7163.c.6538764
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
High-level focal amplification of MET is associated with sensitivity to AMG 337
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591839c3225351858ef11eb77ad3b7db
https://doi.org/10.1158/1535-7163.22507704.v1
https://doi.org/10.1158/1535-7163.22507704.v1
Autor:
Mingqiang Zhang, Angela Coxon, Liaoyuan Hu, Eric Huang, Jacqueline Huang, Hui Zhou, Wenge Zhong, Ouhong Wang, En-Tzu Tang, Ying He, Yanni Zhang, Karen Rex, Yuqing Shen, Sean Caenepeel, Zhiqiang Du
Western blot analysis in responsive PDX model (LI0612) after 14 days treatment. Total and phosphorylated levels of the indicated proteins were evaluated to assess the effects of AMG 337 on MET signaling. Five to twelve PDX samples were processed for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516e46e6e46caf7bc498c6c0043e2135
https://doi.org/10.1158/1535-7163.22503093.v1
https://doi.org/10.1158/1535-7163.22503093.v1
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
Figure S1. Kinase interaction map for AMG 337; Figure S2. In a large unbiased cancer cell line viability screen only MET-amplified cell lines were sensitive to treatment with an analogue of AMG 337 (Compound 5); Figure S3: AMG 337 inhibits the phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17dda613dc16280ece0a724bc5ba127
https://doi.org/10.1158/1535-7163.22507710
https://doi.org/10.1158/1535-7163.22507710
Autor:
Roberto Pili, Angela Coxon, Sean Caenepeel, Karen Rex, Sheng-yu Ku, Swathi Ramakrishnan, Eric Ciamporcero, Sreenivasulu Chintala, Kiersten Marie Miles, Li Shen, Remi Adelaiye-Ogala, Nur P. Damayanti, Ashley R. Orillion, May Elbanna
Receptor tyrosine kinase inhibitors have shown clinical benefit in clear cell renal cell carcinoma (ccRCC), but novel therapeutic strategies are needed. The angiopoietin/Tie2 and MET pathways have been implicated in tumor angiogenesis, metastases, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebe99fdc7b7e064b783cd556b2463ad0
https://doi.org/10.1158/1535-7163.c.6538441.v1
https://doi.org/10.1158/1535-7163.c.6538441.v1