Zobrazeno 1 - 10
of 296
pro vyhledávání: '"Karen Reue"'
Autor:
Peixiang Zhang, Joseph J. Munier, Carrie B. Wiese, Laurent Vergnes, Jenny C. Link, Fahim Abbasi, Emilio Ronquillo, Katherine Scheker, Antonio Muñoz, Yu-Lin Kuang, Elizabeth Theusch, Meng Lu, Gabriela Sanchez, Akinyemi Oni-Orisan, Carlos Iribarren, Michael J. McPhaul, Daniel K. Nomura, Joshua W. Knowles, Ronald M. Krauss, Marisa W. Medina, Karen Reue
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glu
Externí odkaz:
https://doaj.org/article/332ede39ee3b4894add02807a1a4ed96
Autor:
Julian K. Christians, Karen Reue
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Early-life conditions such as prenatal nutrition can have long-term effects on metabolic health, and these effects may differ between males and females. Understanding the biological mechanisms underlying sex differences in the response to early-life
Externí odkaz:
https://doaj.org/article/6b32b968da074c41a5025613488d657e
Autor:
Megan G. Massa, Rachel L. Scott, Alexandra L. Cara, Laura R. Cortes, Paul B. Vander, Norma P. Sandoval, Jae W. Park, Sahara L. Ali, Leandro M. Velez, Huei-Bin Wang, Shomik S. Ati, Bethlehem Tesfaye, Karen Reue, J. Edward van Veen, Marcus M. Seldin, Stephanie M. Correa
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107918- (2023)
Summary: Balance between metabolic and reproductive processes is important for survival, particularly in mammals that gestate their young. How the nervous system coordinates this balance is an active area of study. Herein, we demonstrate that somatos
Externí odkaz:
https://doaj.org/article/abbbb7899b594e65a4ea56c2463a2e6e
Autor:
Kun Do Rhee, Yanjie Wang, Johanna ten Hoeve, Linsey Stiles, Thao Thi Thu Nguyen, Xiangmei Zhang, Laurent Vergnes, Karen Reue, Orian Shirihai, Dean Bok, Xian-Jie Yang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Rhee et al. demonstrates that the potent neuroprotective agent CNTF significantly impacts metabolism of degenerating retinas, thus revealing cellular mechanisms underlying enhanced neuronal viability and providing insight for the ongoing CNTF clinica
Externí odkaz:
https://doaj.org/article/2f8c15a86a74474882c082f8c3e059f3
Publikováno v:
Biology of Sex Differences, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Background Biological sex impacts susceptibility and presentation of cardiovascular disease, which remains the leading cause of death for both sexes. To reduce cardiovascular disease risk, statin drugs are commonly prescribed to reduce circu
Externí odkaz:
https://doaj.org/article/84d4aad7657c4ea2a1131e3ad1422943
Autor:
Joseph J. Munier, Justin T. Pank, Amie Severino, Huan Wang, Peixiang Zhang, Laurent Vergnes, Karen Reue
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Grip strength is a valuable preclinical assay to study muscle physiology in disease and aging by directly determining changes in muscle force generation in active laboratory mice. Existing methods to statistically evaluate grip strength, how
Externí odkaz:
https://doaj.org/article/61de03d0c0bb45b8aa9957945ff01b9f
Autor:
Yang Cao, Laurent Vergnes, Yu-Chen Wang, Calvin Pan, Karthickeyan Chella Krishnan, Timothy M. Moore, Manuel Rosa-Garrido, Todd H. Kimball, Zhiqiang Zhou, Sarada Charugundla, Christoph D. Rau, Marcus M. Seldin, Jessica Wang, Yibin Wang, Thomas M. Vondriska, Karen Reue, Aldons J. Lusis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
In this paper, the authors show that sex differences in mitochondrial DNA levels and function in the heart contribute to sex biases in functions relevant to heart failure, identifying Acsl6 as a mitochondrial sex-biased regulator of diastolic functio
Externí odkaz:
https://doaj.org/article/89de6b77175046a88778990393d83932
Autor:
Saba R. Aliyari, Amir Ali Ghaffari, Olivier Pernet, Kislay Parvatiyar, Yao Wang, Hoda Gerami, Ann-Jay Tong, Laurent Vergnes, Armin Takallou, Adel Zhang, Xiaochao Wei, Linda D. Chilin, Yuntao Wu, Clay F. Semenkovich, Karen Reue, Stephen T. Smale, Benhur Lee, Genhong Cheng
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1624-1635 (2022)
SARS-CoV-2 is an emerging viral pathogen and a major global public health challenge since December of 2019, with limited effective treatments throughout the pandemic. As part of the innate immune response to viral infection, type I interferons (IFN-I
Externí odkaz:
https://doaj.org/article/478f8bc3c0c24622b4fbbf7fef87f486
Autor:
Jeffrey Molendijk, Ronnie Blazev, Richard J Mills, Yaan-Kit Ng, Kevin I Watt, Daryn Chau, Paul Gregorevic, Peter J Crouch, James BW Hilton, Leszek Lisowski, Peixiang Zhang, Karen Reue, Aldons J Lusis, James E Hudson, David E James, Marcus M Seldin, Benjamin L Parker
Publikováno v:
eLife, Vol 11 (2022)
Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle metabolism and function, we performed a proteomic analysis of gastrocnemius muscle from 73 genetically distinct inbred mouse
Externí odkaz:
https://doaj.org/article/76f8d20a7ebb449dbd9f9358e1869662
Autor:
Danielle E. Soranno, Peter Baker, Lara Kirkbride-Romeo, Sara A. Wennersten, Kathy Ding, Brysen Keith, Maria A. Cavasin, Christopher Altmann, Rushita A. Bagchi, Korey R. Haefner, John Montford, Katja M. Gist, Laurent Vergnes, Karen Reue, Zhibin He, Hanan Elajaili, Kayo Okamura, Eva Nozik, Timothy A. McKinsey, Sarah Faubel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Acute kidney injury (AKI) is common in patients, causes systemic sequelae, and predisposes patients to long-term cardiovascular disease. To date, studies of the effects of AKI on cardiovascular outcomes have only been performed in male mice.
Externí odkaz:
https://doaj.org/article/6d0487175e6c4678ae581eca91856780