Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Karen R. Mifsud"'
Autor:
Clare L.M. Kennedy, Emily M. Price, Karen R. Mifsud, Silvia Salatino, Eshita Sharma, Simon Engledow, John Broxholme, Hannah M. Goss, Johannes M.H.M. Reul
Publikováno v:
Neurobiology of Stress, Vol 23, Iss , Pp 100532- (2023)
Hippocampal mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) mediate glucocorticoid hormone (GC) action in the hippocampus. These receptors bind to glucocorticoid responsive elements (GREs) within target genes, eliciting transcrip
Externí odkaz:
https://doaj.org/article/d4ac06cff35a42a68110205729860a09
Autor:
Karen R. Mifsud, Clare L. M. Kennedy, Silvia Salatino, Eshita Sharma, Emily M. Price, Samantha N. Haque, Andriana Gialeli, Hannah M. Goss, Polina E. Panchenko, John Broxholme, Simon Engledow, Helen Lockstone, Oscar Cordero Llana, Johannes M. H. M. Reul
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Glucocorticoid hormones (GCs) are of critical importance for maintaining brain health, but their involvement in mental disorders is poorly understood. Here the authors show how GCs act through hippocampal mineralocorticoid and glucocorticoid receptor
Externí odkaz:
https://doaj.org/article/cab8e81fe2db49c6b2482e6a7549ae9b
Autor:
Johannes M.H.M. Reul, Andrew Collins, Richard S. Saliba, Karen R. Mifsud, Sylvia D. Carter, Maria Gutierrez-Mecinas, Xiaoxiao Qian, Astrid C.E. Linthorst
Publikováno v:
Neurobiology of Stress, Vol 1, Iss C, Pp 44-59 (2015)
Glucocorticoid hormones play a pivotal role in the response to stressful challenges. The surge in glucocorticoid hormone secretion after stress needs to be tightly controlled with characteristics like peak height, curvature and duration depending on
Externí odkaz:
https://doaj.org/article/ee8e2e009cee4a9989dbbd162283aeb7
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
The immediate early genes (IEGs) c-Fos and Egr-1 are rapidly and transiently induced in sparse neurons within the hippocampus after exposure to an acute stressor. The induction of these genes is a critical part of the molecular mechanisms underlying
Externí odkaz:
https://doaj.org/article/6cca2653bcab41a2a26c6efc5f970f5e
Publikováno v:
Epigenomes, Vol 1, Iss 3, p 17 (2017)
Consolidation of contextual memories after a stressful encounter is essential for the survival of an organism and in allowing a more appropriate response to be elicited should the perceived threat reoccur. Recent evidence has explored the complex rol
Externí odkaz:
https://doaj.org/article/c857ba8cd1254eb99aea9212e5719604
Autor:
Silvia Salatino, Clare L. M. Kennedy, Karen R. Mifsud, Johannes M. H. M. Reul, Samantha N. Haque, Eshita Sharma, Oscar Cordero Llana, Polina Panchenko, John Broxholme, Simon Engledow, Hannah M Goss, Andriana Gialeli, Emily M. Price, Helen Lockstone
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Nature Communications
Mifsud, K R, Kennedy, C L M, Salatino, S, Sharma, E, Price, E M, Haque, S N, Gialeli, A, Goss, H M, Panchenko, P E, Broxholme, J, Engledow, S, Lockstone, H, Cordero Llana, O & Reul, J M H M 2021, ' Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors ', Nature Communications, vol. 12, no. 1, 4737 . https://doi.org/10.1038/s41467-021-24967-z
Nature Communications
Mifsud, K R, Kennedy, C L M, Salatino, S, Sharma, E, Price, E M, Haque, S N, Gialeli, A, Goss, H M, Panchenko, P E, Broxholme, J, Engledow, S, Lockstone, H, Cordero Llana, O & Reul, J M H M 2021, ' Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors ', Nature Communications, vol. 12, no. 1, 4737 . https://doi.org/10.1038/s41467-021-24967-z
Glucocorticoid hormones (GCs) — acting through hippocampal mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) — are critical to physiological regulation and behavioural adaptation. We conducted genome-wide MR and GR ChIP-seq and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea357d22ef116b39923225f08ce4b85
https://doaj.org/article/cab8e81fe2db49c6b2482e6a7549ae9b
https://doaj.org/article/cab8e81fe2db49c6b2482e6a7549ae9b
Autor:
Murilo S. de Abreu, Tamara G. Amstislavskaya, Ferenc A. Antoni, Priti Azad, Idu Azogu-Sepe, Andrew A. Bartlett, Luis Federico Bátiz, Yair J. Ben-Efraim, Ryan Bogdan, Erin Bondy, Felipe Bustamante, Murray J. Cairns, Alon Chen, Timothy J. Cole, Quinn Conklin, Konstantin A. Demin, Maarten van den Buuse, Jan M. Deussing, Alec Lindsay Ward Dick, Nourhan M. Elsayed, Laura C. Etzel, Nir Eynon, Peter J. Fuller, Jenny M. Gunnersen, Gabriel G. Haddad, Samantha N. Haque, Roberto Henzi, David W. Hogg, Sharon L. Hollins, Richard G. Hunter, Macsue Jacques, Allan V. Kalueff, Martin J. Kelly, Charlotte Kling, Vinay Kumar, Shanie Landen, Dominic Landgraf, Hui Li, David A. Lovejoy, Bin-Guang Ma, Isabelle M. Mansuy, Stefanie Mayer, Maxs Méndez-Ruette, Karen R. Mifsud, Pierre Mormede, Mark Murphy, Pooja Negi, Charles B. Nemeroff, Michael Notaras, Amanda J. Page, Andrew S. Palmer, Jonathan Parker, Sarah E. Paul, Suprasanna Penna, Hélène Plamondon, Emily M. Price, Johannes M.H.M. Reul, Kathryn K. Ridout, Samuel J. Ridout, Oline K. Rønnekleiv, Dipak K. Sarkar, Idan Shalev, Gretchen van Steenwyk, Tsering Stobdan, Tatyana Strekalova, Elena Terenina, Sarah Voisin, Xu-Ting Wang, Yvette M. Wilson, Ursula Wyneken, Shi-Di Xiao, Morag J. Young, Dan Zhou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::399032a1a7153eba88ec47e3a291567d
https://doi.org/10.1016/b978-0-12-813156-5.09995-7
https://doi.org/10.1016/b978-0-12-813156-5.09995-7
Glucocorticoid hormone-binding receptors are vital to many biological processes. The effects of receptor activation after stress or during the circadian peak can be observed organism wide in altered physiology and behavior, as well as changes in cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c20664be390497a12c1b6f2d407f05b0
https://doi.org/10.1016/b978-0-12-813156-5.00020-0
https://doi.org/10.1016/b978-0-12-813156-5.00020-0
Autor:
Clare L. M. Kennedy, Johannes M. H. M. Reul, Karen R. Mifsud, E. Price, Eshita Sharma, H.M. Goss, Silvia Salatino
Publikováno v:
European Neuropsychopharmacology. 40:S480-S481
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd3ff13d5462dab62dc1f70ec5f20011
https://doi.org/10.1016/j.euroneuro.2020.09.624
https://doi.org/10.1016/j.euroneuro.2020.09.624
Publikováno v:
Mifsud, K R & Reul, J M H M 2018, ' Mineralocorticoid and glucocorticoid receptor-mediated control of genomic responses to stress in the brain ', Stress, pp. 1-14 . https://doi.org/10.1080/10253890.2018.1456526
Successful coping with stressful events involves adaptive and cognitive processes in the brain that make the individual more resilient to similar stressors in the future. Stressful events result in the secretion of glucocorticoids (GCs) from the adre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4cbccd1fdea593cb9986f40f40ada29
https://hdl.handle.net/1983/acaadd47-d6fd-4424-9897-5aed34c037e8
https://hdl.handle.net/1983/acaadd47-d6fd-4424-9897-5aed34c037e8