Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Karen R. Leander"'
Autor:
Qing-Bai She, Sarat Chandarlapaty, Qing Ye, Jose Lobo, Kathleen M Haskell, Karen R Leander, Deborah DeFeo-Jones, Hans E Huber, Neal Rosen
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e3065 (2008)
Dysregulated PI3K/Akt signaling occurs commonly in breast cancers and is due to HER2 amplification, PI3K mutation or PTEN inactivation. The objective of this study was to determine the role of Akt activation in breast cancer as a function of mechanis
Externí odkaz:
https://doaj.org/article/b5b859fcec964286a6785e18f0e5d4e2
Autor:
Rob S. Burke, Karen R. Leander, Rubina G. Parmar, Mihir Patel, Laura Sepp-Lorenzino, Steven L. Colletti, Weimin Wang, Andrew H. Latham, Sean Riley, Brian A. Carr, J. Michael Williams, Eric D. Soli, Eileen S. Walsh, Micheal Poslusney, Eric Kemp, Anthony Leone, Marina Busuek, Robert M. Garbaccio, Bonnie J. Howell
Publikováno v:
Bioconjugate Chemistry. 25:896-906
The application of small interfering (si)RNAs as potential therapeutic agents requires safe and effective methods for their delivery to the cytoplasm of the target cells and tissues. Recent studies have shown significant progress in the development o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8480aca54e9cb5f5dca8c2baef4c0840
https://doi.org/10.1021/bc400527e
https://doi.org/10.1021/bc400527e
Autor:
Stephanie Young, Weikang Tao, Bonnie J. Howell, Ed Carlini, Marc Abrams, Edward Keough, Alan B. Sachs, Laura Sepp-Lorenzino, Andrea Matter, Karen R. Leander, Bin Shi
Publikováno v:
Journal of Histochemistry & Cytochemistry. 59:727-740
Chemically stabilized small interfering RNA (siRNA) can be delivered systemically by intravenous injection of lipid nanoparticles (LNPs) in rodents and primates. The biodistribution and kinetics of LNP–siRNA delivery in mice at organ and cellular r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8fb9589171de40eeb1680b0c58a8ff
https://doi.org/10.1369/0022155411410885
https://doi.org/10.1369/0022155411410885
Autor:
Martin G. Sanda, Karen R. Leander, Deborah Defeo-Jones, Mohamed S. Arredouani, Clara Hwang, Brent K. Hollenbeck, Stephanie Tseng-Rogenski, June Escara-Wilke
Publikováno v:
The Prostate. 70:1002-1011
BACKGROUND In recent years, there has been an increasing interest in targeting human prostate tumor-associated antigens (TAAs) for prostate cancer immunotherapy as an alternative to other therapeutic modalities. However, immunologic tolerance to TAA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ae48e09a03ad64117d76848ff1f969e
https://doi.org/10.1002/pros.21134
https://doi.org/10.1002/pros.21134
Autor:
Deborah DeFeo-Jones, Stanley F. Barnett, Sheng Fu, Paula J. Hancock, Kathleen M. Haskell, Karen R. Leander, Elizabeth McAvoy, Ronald G. Robinson, Mark E. Duggan, Craig W. Lindsley, Zhijian Zhao, Hans E. Huber, Raymond E. Jones
Publikováno v:
Molecular Cancer Therapeutics. 4:271-279
Recent studies indicate that dysregulation of the Akt/PKB family of serine/threonine kinases is a prominent feature of many human cancers. The Akt/PKB family is composed of three members termed Akt1/PKBα, Akt2/PKBβ, and Akt3/PKBγ. It is currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01ddea941ec2a77b4df46e95406206be
https://doi.org/10.1158/1535-7163.271.4.2
https://doi.org/10.1158/1535-7163.271.4.2
Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit
Autor:
Laura Sepp-Lorenzino, Anil Thankappan, Yuchen Zhou, Traci Q. Lifsted, Jillian DiMuzio, Karen R. Leander, Marija Tadin-Strapps, Laura S. Lubbers, Lizbeth Hoos, Zhu Chen, Bruce Ng, Peter Szczerba, Marian E. Gindy, Seth Clark, Weizhen Wu, Bin Luo, Nina Jochnowitz, Dietmar Seiffert, Jyoti Disa, Tian-Quan Cai, Marty DiPietro, Yiming Xu, Walter Strapps, Christine Jachec
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
The present study aimed at establishing feasibility of delivering short interfering RNA (siRNA) to target the coagulation cascade in rat and rabbit, two commonly used species for studying thrombosis and hemostasis. siRNAs that produced over 90% mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee05c8b66674560f150adcec95a940b
https://pubmed.ncbi.nlm.nih.gov/25625614
https://pubmed.ncbi.nlm.nih.gov/25625614
Autor:
Lizbeth M. Hoos, Laura Sepp-Lorenzino, Walter Strapps, John Levorse, Dietmar Seiffert, Karen R. Leander, Marti DiPietro, Yuchen Zhou, Anil Thankappan, Weizhen Wu, Tian-Quan Cai, Zuo Zhang, Zhu Chen, Yiming Xu, Marija Tadin-Strapps, Myung K. Shin, Patrick Andre, Joseph M. Metzger, Kunal Desai, KehDih Lai, Nina Jochnowitz, Ross Bentley
Publikováno v:
Thrombosis and haemostasis. 113(6)
SummaryHaemophilia A and B are characterised by a life-long bleeding predisposition, and several lines of evidence suggest that risks of atherothrombotic events may also be reduced. Establishing a direct correlation between coagulation factor levels,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c451ee47e663a79cf3f2011d6a5ea178
https://pubmed.ncbi.nlm.nih.gov/25790442
https://pubmed.ncbi.nlm.nih.gov/25790442
Autor:
Sean Riley, Robert M. Garbaccio, Bonnie J. Howell, Sergey Pechenov, Robert A. Kowtoniuk, Eric Kemp, Anthony Leone, Eileen S. Walsh, Steven L. Colletti, Louis S. Crocker, J. Michael Williams, Mihir Patel, Marc Abrams, Andrew H. Latham, Laura Sepp-Lorenzino, Brian A. Carr, Karen R. Leander, Nicole T. Pudvah, Rob S. Burke, Stephanie E. Barrett
Publikováno v:
International journal of pharmaceutics. 466(1-2)
A series of amphiphilic, biodegradable polypeptide copolymers were prepared for the delivery of siRNA (short interfering ribonucleic acid). The molecular weight (or polymer chain length) of the linear polymer was controlled by reaction stoichiometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9719dda6f2ef975fbe289205a2fda3e1
https://pubmed.ncbi.nlm.nih.gov/24607208
https://pubmed.ncbi.nlm.nih.gov/24607208
Autor:
Stanley F. Barnett, Nicholas D. P. Cosford, Deborah Defeo-Jones, Michael A. Rossi, Jun Liang, Hans E. Huber, Ronald G. Robinson, Raymond E. Jones, Hu Essa H, Yiwei Li, Sachin Mittal, Karen R. Leander, Tony Siu, Peppi Prasit
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:834-836
A series of [1,2,4]triazolo[3,4-f][1,6]naphthyridine allosteric dual inhibitors of Akt1 and 2 have been developed. These compounds have been shown to have potent dual Akt1 and 2 cell potency. The representative compound 13 provided potent inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ba20e71cf707c07711af7cafaca26d
https://doi.org/10.1016/j.bmcl.2008.12.017
https://doi.org/10.1016/j.bmcl.2008.12.017
Autor:
Laura Sepp-Lorenzino, Bonnie J. Howell, Eric Kemp, Robert M. Garbaccio, Steven L. Colletti, Brian A. Carr, Marina Busuek, Louis S. Crocker, Karen R. Leander, Anthony Leone, Christopher J. Kochansky, Weimin Wang, Rubina G. Parmar, Eileen S. Walsh
Publikováno v:
Bioconjugate chemistry. 24(4)
Efficient siRNA delivery is dependent not only on the ability of the delivery vehicle to target a specific organ but also on its ability to enable siRNA entry into the cytoplasm of the target cells. Polymers with endosomolytic properties are increasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c71cc21054733d03e25df9ad7b42d68
https://pubmed.ncbi.nlm.nih.gov/23496378
https://pubmed.ncbi.nlm.nih.gov/23496378