Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Karen R. Groot"'
Autor:
Karen R. Groot, Elizabeth K. Sage, Vitor H. Teixeira, Adam Giangreco, L Lu, Ekaterina V. Ilieva, Sam M. Janes, P. Jeremy George, Fiona M. Watt, Andrew G. Nicholson, Charles Vickers, Colin R. Butler
Publikováno v:
The Journal of Pathology
Human lung cancers, including squamous cell carcinoma (SCC) are a leading cause of death and, whilst evidence suggests that basal stem cells drive SCC initiation and progression, the mechanisms regulating these processes remain unknown. In this study
Publikováno v:
Journal of Cell Science. 121:3561-3569
Kazrin is an evolutionarily conserved protein that is upregulated during keratinocyte terminal differentiation. Kazrin localizes to desmosomes and binds the epidermal cornified envelope protein periplakin. Kazrin overexpression in human epidermal ker
Publikováno v:
The Journal of Cell Biology
Periplakin forms part of the scaffold onto which the epidermal cornified envelope is assembled. The NH2-terminal 133 amino acids mediate association with the plasma membrane and bind a novel protein, kazrin. Kazrin is highly conserved and lacks homol
Autor:
Mariya Chhatriwala, Lisa M. Sevilla, Rachida Nachat, Fiona M. Watt, Karen R. Groot, Sara Cipolat
Kazrin is a widely expressed, evolutionarily conserved cytoplasmic protein that binds the cytolinker protein periplakin. Multiple functions of kazrin have been reported, including regulation of desmosome assembly, embryonic tissue morphogenesis and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc4ceb986ad0d5b31e64e6a2fe3d8d2
https://europepmc.org/articles/PMC2776498/
https://europepmc.org/articles/PMC2776498/
Autor:
Lisa M. Sevilla, Arto Määttä, Rachida Nachat, Jouni Uitto, John F. Klement, Philippe Djian, Fiona M. Watt, Karen R. Groot
Publikováno v:
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2007, 179 (7), pp.1599-612. ⟨10.1083/jcb.200706187⟩
The Journal of Cell Biology
Journal of cell biology, 2007, Vol.179(7), pp.1599-1612 [Peer Reviewed Journal]
Journal of Cell Biology, Rockefeller University Press, 2007, 179 (7), pp.1599-612. ⟨10.1083/jcb.200706187⟩
The Journal of Cell Biology
Journal of cell biology, 2007, Vol.179(7), pp.1599-1612 [Peer Reviewed Journal]
The cornified envelope is assembled from transglutaminase cross-linked proteins and lipids in the outermost epidermal layers and is essential for skin barrier function. Involucrin, envoplakin, and periplakin form the protein scaffold on which the env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1057b0d6fa93031a48b5e01958c72576
https://hal.archives-ouvertes.fr/hal-00203377
https://hal.archives-ouvertes.fr/hal-00203377
Autor:
Catherine Simpson, K Allen, L Bazley, Neal Navani, Karen R. Groot, Derek Davies, Sam M. Janes, L Prichard, Michael R. Loebinger, Adam Giangreco, S Tibrewal
Publikováno v:
British Journal of Cancer
Cancers are a heterogeneous mix of cells, some of which exhibit cancer stem cell-like characteristics including ATP-dependent drug efflux and elevated tumorigenic potential. To determine whether aerodigestive squamous cell carcinomas (SCCs) contain a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd89b573077eba44b862b3968f14629
http://hdl.handle.net/10044/1/28739
http://hdl.handle.net/10044/1/28739
Publikováno v:
American journal of respiratory and critical care medicine. 175(6)
Lung cancer is a significant disease with survival rates remaining poor despite numerous therapeutic advances during the last 30 years. Understanding lung cancer pathogenesis through murine modeling may improve future human therapies, and new data in
Publikováno v:
Molecular and cellular biology. 21(20)
Envoplakin, a member of the plakin family of cytoskeletal linker proteins, is localized in desmosomes of stratified epithelial cells and is a component of the epidermal cornified envelope. Gene targeting in mouse embryonic stem cells was used to gene