Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Karen R Lien"'
Autor:
Silvana B De Lorenzo, Alyssa M Vrieze, Ruth A Johnson, Karen R Lien, Karl A Nath, Vesna D Garovic, Khashayarsha Khazaie, Joseph P Grande
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266454 (2022)
Progression of virtually all forms of chronic kidney disease (CKD) is associated with activation of pro-inflammatory and pro-fibrotic signaling pathways. Despite extensive research, progress in identifying therapeutic targets to arrest or slow progre
Externí odkaz:
https://doaj.org/article/9eb2349e87b449389dd73b2b8d888d0a
Autor:
Sonu Kashyap, Gina Warner, Zeng Hu, Feng Gao, Mazen Osman, Yousif Al Saiegh, Karen R Lien, Karl Nath, Joseph P Grande
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187062 (2017)
Renovascular hypertension (RVH) has deleterious effects on both the kidney and the heart. TGF-β signaling through Smad3 directs tissue fibrosis in chronic injury models. In the 2-kidney 1-clip (2K1C) model of RVH, employing mice on the 129 genetic b
Externí odkaz:
https://doaj.org/article/2a28ca6fdbb743dcb061f0dbaf2c1d47
Autor:
Scott M Thompson, Matthew R Callstrom, Danielle E Jondal, Kim A Butters, Bruce E Knudsen, Jill L Anderson, Karen R Lien, Shari L Sutor, Ju-Seog Lee, Snorri S Thorgeirsson, Joseph P Grande, Lewis R Roberts, David A Woodrum
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162634 (2016)
Thermal ablative therapies are important treatment options in the multidisciplinary care of patients with hepatocellular carcinoma (HCC), but lesions larger than 2-3 cm are plagued with high local recurrence rates and overall survival of these patien
Externí odkaz:
https://doaj.org/article/e83b5fbefa69405fb91d616b208b0ea9
Autor:
Silvana B. De Lorenzo, Alyssa M. Vrieze, Ruth A. Johnson, Karen R. Lien, Karl A. Nath, Vesna D. Garovic, Khashayarsha Khazaie, Joseph P. Grande
Publikováno v:
PloS one. 17(4)
Progression of virtually all forms of chronic kidney disease (CKD) is associated with activation of pro-inflammatory and pro-fibrotic signaling pathways. Despite extensive research, progress in identifying therapeutic targets to arrest or slow progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b7c1b5d0bd1cdc870da1240ad96067
https://pubmed.ncbi.nlm.nih.gov/35413089
https://pubmed.ncbi.nlm.nih.gov/35413089
Autor:
Karl A. Nath, Stella P. Hartono, Karen R. Lien, Lilach O. Lerman, Joseph P. Grande, Sonu Kashyap, Rajendra Boyilla, Bruce E. Knudsen, Adeel S. Zubair, Gina M. Warner, Stephen C. Textor
Publikováno v:
American Journal of Physiology-Renal Physiology. 310:F372-F384
Renovascular hypertension (RVH) is a common cause of both cardiovascular and renal morbidity and mortality. In renal artery stenosis (RAS), atrophy in the stenotic kidney is associated with an influx of macrophages and other mononuclear cells. We tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1f49ef8dd891ea61970f2cb484d6db
https://doi.org/10.1152/ajprenal.00131.2015
https://doi.org/10.1152/ajprenal.00131.2015
Autor:
Vesna D. Garovic, Lilach O. Lerman, Karen R. Lien, Joseph P. Grande, Christopher M. Ferguson, Sonu Kashyap, Karl A. Nath, Mazen Osman, Meryl C. Nath, Bhaskar Roy
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Inflammation plays an important role in the pathogenesis of renal and cardiovascular disease in renovascular hypertension (RVH). Ccl2 is an important mediator of inflammation, and is induced within 24 hours following surgery to establish RVH in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beff98bad9160a1cea37c71a8daae663
https://doi.org/10.1038/s41598-018-26870-y
https://doi.org/10.1038/s41598-018-26870-y
Autor:
Mazen Osman, Sonu Kashyap, Feng Gao, Zeng Hu, Yousif Al Saiegh, Karl A. Nath, Gina M. Warner, Karen R. Lien, Joseph P. Grande
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187062 (2017)
PLoS ONE
PLoS ONE
Renovascular hypertension (RVH) has deleterious effects on both the kidney and the heart. TGF-β signaling through Smad3 directs tissue fibrosis in chronic injury models. In the 2-kidney 1-clip (2K1C) model of RVH, employing mice on the 129 genetic b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4608186cac83b9fc0ddfbb1a5c643c6a
http://europepmc.org/articles/PMC5658153?pdf=render
http://europepmc.org/articles/PMC5658153?pdf=render
Autor:
Karen R. Lien, Scott M. Thompson, Danielle E. Jondal, Joseph P. Grande, Shari L. Sutor, Jill L. Anderson, Bruce E. Knudsen, Kim A. Butters, Ju Seog Lee, Lewis R. Roberts, Snorri S. Thorgeirsson, Matthew R. Callstrom, David A. Woodrum
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0162634 (2016)
PLoS ONE, Vol 11, Iss 9, p e0162634 (2016)
Thermal ablative therapies are important treatment options in the multidisciplinary care of patients with hepatocellular carcinoma (HCC), but lesions larger than 2-3 cm are plagued with high local recurrence rates and overall survival of these patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3aabb5531c5336839fc6c82ecbca3bb
https://pubmed.ncbi.nlm.nih.gov/27611696
https://pubmed.ncbi.nlm.nih.gov/27611696
Inhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model
Autor:
Gina M. Warner, Kim A. Butters, Lilach O. Lerman, Ping Yin, Catherine E. Gray, Vesna D. Garovic, Diping Wang, Stephen C. Textor, Jingfei Cheng, Bruce E. Knudsen, Karen R. Lien, Robert D. Simari, Joseph P. Grande, Karl A. Nath
Publikováno v:
American journal of physiology. Renal physiology. 304(7)
Renal artery stenosis (RAS) is an important cause of chronic renal dysfunction. Recent studies have underscored a critical role for CCL2 (MCP-1)-mediated inflammation in the progression of chronic renal damage in RAS and other chronic renal diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49b97a4a77df6ac7b71ab5ca0b81d95
https://pubmed.ncbi.nlm.nih.gov/23364805
https://pubmed.ncbi.nlm.nih.gov/23364805
Autor:
Catherine E. Gray, Jorg Kaiser, Justin E. Juskewitch, Jingfei Cheng, Karen R. Lien, Bruce E. Knudsen, Joseph P. Grande, Gina M. Warner
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a93d9906de48463c17a8d30bf8b691a
https://doi.org/10.1096/fasebj.26.1_supplement.872.14
https://doi.org/10.1096/fasebj.26.1_supplement.872.14