LIM Kinases, Promising but Reluctant Therapeutic Targets: Chemistry and Preclinical Validation In Vivo

Autor: Rayan Berabez, Sylvain Routier, Hélène Bénédetti, Karen Plé, Béatrice Vallée

Publikováno v: Cells, Vol 11, Iss 13, p 2090 (2022)

LIM Kinases are important actors in the regulation of cytoskeleton dynamics by controlling microtubule and actin filament turnover. The signaling pathways involving LIM kinases for actin filament remodeling are well established. They are downstream e

Externí odkaz: https://doaj.org/article/b28c384611024df3a87676a8f1a8312d

A Further Contribution to the Study of Sagittamide A: Synthesis of a Pivotal Intermediate Belonging to a Rare L-Series

Autor: Anne Humbert, Karen Plé, Dominique Harakat, Agathe Martinez, Arnaud Haudrechy

Publikováno v: Molecules, Vol 17, Iss 7, Pp 7709-7721 (2012)

A key saggitamide intermediate corresponding to a rare sugar framework has been obtained. This approach should help to establish the overall configuration of more complex structures of the sagittamide family.

Externí odkaz: https://doaj.org/article/572f4114d1914b18952fc1f876801361

Synthesis of Heterospirocycles through Gold‐(I) Catalysis: Useful Building Blocks for Medicinal Chemistry

Autor: Kossi Efouako Soklou, Hamid Marzag, Karen Plé, Sylvain Routier, Béatrice Vallée

Publikováno v: Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis, 2021, ⟨10.1002/adsc.202101080⟩
Advanced Synthesis and Catalysis, Wiley-VCH Verlag, In press, ⟨10.1002/adsc.202101080⟩

International audience; Gold-(I) catalysis was used for the intramolecular cyclization of tertiary alcohols with terminal alkynes to form diverse aza-spirocycles. The reaction was carried out with low catalyst loading under microwave irradiation to g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac627a42052b7d702a0932f9bcbc082
https://doi.org/10.1002/adsc.202101080

Gold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles

Autor: Sylvain Routier, Kossi Efouako Soklou, Karen Plé, Mathieu Marchivie, Jean-Philippe Bouillon, Hamid Marzag

Publikováno v: Organic Letters
Organic Letters, 2020, 22 (15), pp.5973-5977. ⟨10.1021/acs.orglett.0c02070⟩
Organic Letters, American Chemical Society, 2020, 22 (15), pp.5973-5977. ⟨10.1021/acs.orglett.0c02070⟩

International audience; We report here a simple and robust gold-catalyzed annulation reaction, giving N- and O-spirocycles in good to excellent yields. We have prepared a library of protected amines and tertiary alcohols that give, upon cyclization w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073b44938c5f0da62294627051303c9f
https://doi.org/10.1021/acs.orglett.0c02070

Perinatal Exposure to the Cyanotoxin β-N-Méthylamino-l-Alanine (BMAA) Results in Long-Lasting Behavioral Changes in Offspring—Potential Involvement of DNA Damage and Oxidative Stress

Autor: Géraldine Meyer-Dilhet, Justyne Feat, Asma Oummadi, Anthony Laugeray, Gilles J. Guillemin, Stéphane Mortaud, Clément Jourdain, Arnaud Menuet, Sylvain Routier, Karen Plé

Publikováno v: Neurotoxicity Research
Neurotoxicity Research, Springer Verlag, 2018, 33 (1), pp.87-112. ⟨10.1007/s12640-017-9802-1⟩
Neurotoxicity Research, 2018, 33 (1), pp.87-112. ⟨10.1007/s12640-017-9802-1⟩

We recently demonstrated that perinatal exposure to the glutamate-related herbicide, glufosinate ammonium, has deleterious effects on neural stem cell (NSC) homeostasis within the sub-ventricular zone (SVZ), probably leading to ASD-like symptoms in o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d653e8a54b818125acf4aed5eb4d00b
https://hal.archives-ouvertes.fr/hal-02447420